Synthesis method of high-selectivity 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol

A trifluoromethyl, high-selectivity technology, applied in organic chemistry and other directions, can solve problems such as poor selectivity, unfavorable industrial production, and violent reaction process, and achieve improved selectivity and yield, easy control of the reaction process, and reaction conditions. mild effect
CN113979944AActive Publication Date: 2022-01-28杭州欧晨科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
杭州欧晨科技有限公司
Publication Date
2022-01-28

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Abstract

The invention discloses a synthesis method of high-selectivity 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol, the synthesis method comprises the following steps: taking ethyl 4, 4, 4-trifluoroacetoacetate and a methylhydrazine aqueous solution as raw materials, carrying out condensation cyclization reaction in the presence of an organic solvent and a catalyst, after the reaction is finished, filtering the reaction system, washing and drying, and obtaining the target product 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol. According to the invention, cheap raw materials and solvents are adopted, and the reagent ethanol can be generated in the reaction, so that the reaction can be carried out in the forward direction, the reaction efficiency is improved, the reaction conditions are mild, and the reaction process is easy to control; by adding the limited catalyst, the selectivity and the yield of the reaction can be further improved, the yield reaches up to 95% or above, the selectivity of the target product to the byproduct is greater than 99: 1, and the method not only ensures high-selectivity preparation of the target product, but also is relatively high in overall yield, relatively low in cost, less in environmental pollution and suitable for industrial production.
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Description

Technical field

[0001] The present invention relates to the field of organic chemical synthesis, and in particular, 1-methyl-3-methyl-1-pyrazole-3-alcohol-1-pyrazol-3-alcohol-1H-pyrazol-3-alcohol-1H-pyrazole-3-alcohol-1H-(trifluoromethyl) -1H-pyrazole-3-alcohol-1H Synthesis of 3- (trifluoromethyl) -1H-pyrazole-5-alcohol. Background technique

[0002] The pyrazole compound is a very valuable organic compound that has a high biological activity in many pyrazole compounds, and has a wide range of applications in many fields. As in medical applications, pyrazole compounds have efficacy to many diseases; in the application of pesticide applications, the pyrazole compound has insecticidal, bactericidal and removal activity, and exhibits efficient, low toxicity and structural diversity; Such compounds are also in chemicals in various fields such as dyes, coatings, perfumes, detergents, surfactants. Therefore, it is important to study and develop pyrazole compounds.

[0003] 1-methyl-3- ...

Claims

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