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89 results about "CMN pyrazole" patented technology

Methyl jasmonate and CMN-pyrazole applied alone and in combination can cause mature orange abscission ☆

Novel sustained-release long-acting compound fertilizer and preparation method thereof

The invention relates to a sustained-release long-acting fertilizer, in particular to a stable fertilizer capable of achieving sustained release and long acting by regulating the conversion process of mineral elements in soil by a novel composite regulating agent. The sustained-release long-acting fertilizer is prepared by mixing a compound fertilizer containing amide nitrogen or ammonium nitrogen with the novel composite regulating agent -in a certain proportion. The novel composite regulating agent is formed by compounding three types of substances in a proper proportion, wherein borax or boric acid simultaneously serves as a synergist for a urease inhibitor and a nitrification inhibitor, and as a plant essential nutrient element; dicyandiamide, 3,5-dimethyl pyrazole, 2-chloro-6-(trichloromethyl) pyridine or the like serve as the nitrification inhibitor; and a humic acid substance serves as the synergist. Compared with a traditional compound (composite) fertilizer, after the fertilizer added with the novel composite regulating agent is applied into soil, the conversion of the nutrient of the fertilizer in soil can be effectively regulated, furthermore the nutrient release period can be effectively prolonged, the nutrient utilization rate can be improved, and environment pollution can be reduced.
Owner:辽宁盛源肥业科技有限公司

Synthesis method of anagliptin

The invention relates to a synthesis method of bulk drug of anagliptin for treating II type diabetes, and aims to solve the problem that at present there is no industrial synthesis method of anagliptin. The synthesis method comprises the following steps: (1) taking vinyl ethyl ether and trichloroacetic chloride as the raw materials, carrying out three-step reactions to obtain an intermediate (4) with a protected aldehyde group; carrying out dehydration condensation between the intermediate (4) and 3-amino-5-methylpyrazole to obtain pyrazolopyrimidine parent nucleus; and hydrolyzing carboxyl ethyl ester to obtain 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid6; (2) taking L-proline as the raw material, subjecting L-proline to methyl esterification, ammoniation, acetylation, and cyaniding reactions to obtain a chiral cyanopyrrole intermediate (11); making the chiral cyanopyrrole intermediate (11) and a diamine segment (12) carry out nucleophilic substitution reactions under an alkaline condition to obtain an intermediate (13), and finally removing the Boc protective group from the intermediate (13) in the presence of hydrochloric acid to obtain a cyanopyrrole amine intermediate (14); (3) coupling 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 6 with the cyanopyrrole amine intermediate (14) under condensation conditions so as to obtain the bulk drug anagliptin.
Owner:南通佰康生物医药有限公司

Synthesis method of high-selectivity 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol

The invention discloses a synthesis method of high-selectivity 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol, the synthesis method comprises the following steps: taking ethyl 4, 4, 4-trifluoroacetoacetate and a methylhydrazine aqueous solution as raw materials, carrying out condensation cyclization reaction in the presence of an organic solvent and a catalyst, after the reaction is finished, filtering the reaction system, washing and drying, and obtaining the target product 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol. According to the invention, cheap raw materials and solvents are adopted, and the reagent ethanol can be generated in the reaction, so that the reaction can be carried out in the forward direction, the reaction efficiency is improved, the reaction conditions are mild, and the reaction process is easy to control; by adding the limited catalyst, the selectivity and the yield of the reaction can be further improved, the yield reaches up to 95% or above, the selectivity of the target product to the byproduct is greater than 99: 1, and the method not only ensures high-selectivity preparation of the target product, but also is relatively high in overall yield, relatively low in cost, less in environmental pollution and suitable for industrial production.
Owner:杭州欧晨科技有限公司
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