89 results about "CMN pyrazole" patented technology

The invention provides a preparation method of 3-difluoro-methyl-1H-methyl pyrazole-4-carboxylic acid shown in the formula (I) or 3-trifluoro-methyl-1H-methyl pyrazole-4-carboxylic acid shown in the formula (II), and the method comprises the following steps of: (a) providing a 3-polyfluoro methyl-1H-pyrazole-4-nitrile group shown in the formula (VII); and (b) under the condition of participation of acid or alkaline, carrying out hydrolysis reaction on the 3-polyfluoro methyl-1H-pyrazole-4-nitrile group shown in the formula (VII), thus obtaining the 3-difluoro-methyl-1H-methyl pyrazole-4-carboxylic acid shown in the formula (I) or 3-trifluoro-methyl-1H-methyl pyrazole-4-carboxylic acid shown in the formula (II).

The invention relates to a synthesis method of bulk drug of anagliptin for treating II type diabetes, and aims to solve the problem that at present there is no industrial synthesis method of anagliptin. The synthesis method comprises the following steps: (1) taking vinyl ethyl ether and trichloroacetic chloride as the raw materials, carrying out three-step reactions to obtain an intermediate (4) with a protected aldehyde group; carrying out dehydration condensation between the intermediate (4) and 3-amino-5-methylpyrazole to obtain pyrazolopyrimidine parent nucleus; and hydrolyzing carboxyl ethyl ester to obtain 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid6; (2) taking L-proline as the raw material, subjecting L-proline to methyl esterification, ammoniation, acetylation, and cyaniding reactions to obtain a chiral cyanopyrrole intermediate (11); making the chiral cyanopyrrole intermediate (11) and a diamine segment (12) carry out nucleophilic substitution reactions under an alkaline condition to obtain an intermediate (13), and finally removing the Boc protective group from the intermediate (13) in the presence of hydrochloric acid to obtain a cyanopyrrole amine intermediate (14); (3) coupling 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 6 with the cyanopyrrole amine intermediate (14) under condensation conditions so as to obtain the bulk drug anagliptin.

The invention relates to a special slow-release long-acting compound fertilizer for carrot and an application method for the special slow-release long-acting compound fertilizer. The fertilizer is composed of active ingredients and auxiliary materials, wherein the active ingredients comprise, in parts by weight, 20-25 parts of nitrogen, 8-12 parts of phosphorus (P2O5), 14-18 parts of potassium (K2O), and an inhibitor with an addition amount which is 2-4% of the dosage of nitrogen in the compound fertilizer, wherein the inhibitor is a composite inhibitor composed of a urease inhibitor and a nitrification inhibitor at a weight ratio of 1: (2-5); the urease inhibitor is hydroquinone or N-butyl thiophosphoramide; and the nitrification inhibitor is dicyandiamide, 2-chloro-6-(trichloromethyl) pyridine, 2-amino-4-chloro-6-methyl pyridine, 3,4-dimethylpyrazole phosphate, 3,5-dimethylpyrazole or 3,5-dimethylpyrazole phosphate. The fertilizer is capable of meeting the needs of a whole growth period on nutrients by being applied once before carrot planting, high in yield, and excellent in quality.

The invention discloses a photochromic naphthalimido Cd-MOF, a preparation method thereof, photochromic printing paste and application, and belongs to the field of functional photosensitive fabrics. The molecular formula of the photochromic naphthalimido Cd-MOF is Cd (BDC) (H2NDI). 4H2O, wherein H2NDI is 2, 7-(3, 5-dimethyl- 1H-pyrazole)-1, 4, 5, 8-naphthalene tetracarboxylic diimide, and H2BDC isterephthalic acid. The preparation method disclosed by the invention is simple, feasible and convenient to operate, does not generate toxic gas in the whole process, is green and environment-friendly, conforms to the concept of sustainable development, has no special requirements on equipment, can be used for large-scale production, and has a good and wide development prospect. The photochromic MOFs material is innovatively combined with the traditional textile, so that the characteristics of the textile before and after finishing are kept, the advantages of the MOFs in structure regulation and control can be inherited, and the photochromic behavior and color change of the photosensitive textile are regulated and controlled by utilizing the change of photochromic structure elements.

The invention discloses a synthesis method of 3-difluoromethyl-1-methylpyrazole-4-formic acid, and belongs to the technical field of difluoromethyl pyrazole synthesis. According to the synthesis method, 3-difluoromethyl-1-methylpyrazole-4-formic acid is prepared from 1-dimethylamino-1-butylene-3-one, difluoroacetyl fluoride, and methyl hydrazine through a series of reactions. The provided synthesis method has the advantages of easily available raw materials and high yield, can be applied to industry, and has a comprehensive yield more than 65%.

The invention relates to a synthetic method of 1-methyl 4-pyrazole pinacol ester. The biggest advantage of the invention is that the technology is greatly improved; and the problem that the preparation technology of 1-methyl 4-pyrazole pinacol ester is limited in a laboratory and there is no large-scale production is solved. The technical scheme provided by the invention is as follows: the synthetic method of 1-methyl 4-pyrazole pinacol ester comprises The following steps of: Step 1, performing a reaction between 1-methyl 4-pyrazole and triisopropyl borate under the action of n-butyllithium to obtain an intermediate A; and Step 2, performing a reaction between the intermediate A and pinacol under the action of magnesium sulfate to obtain the target product 1-methyl 4-pyrazole pinacol ester. The obtained 1-methyl 4-pyrazole pinacol ester is an important intermediate commonly-used in pharmaceutical chemistry.

The invention discloses a preparation method of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: with 1,3-dimethylpyrazole as a raw material, carrying out halogenation to obtain 4-halogenated-1,3,5-tetrahydronaphthalene; carrying out a reaction under the conditions of a bromination reagent and AIBN and hydrolysis with hexamethylenetetramine to obtain 4-halogen-1-methyl-1H-pyrazole-3-formaldehyde, then performing a reaction with a fluorination reagent to obtain 4-halogen-3-difluoromethyl-1-methylpyrazole; finally carrying out a reaction on the 4-halogen-3-difluoromethyl-1-methylpyrazole and a Grignard reagent to obtain 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester. The method is simple and convenient to operate and high in reaction yield, the purity of the obtained product can reach 99.5% or above, and the method has a potential process amplification prospect.

The invention relates to a synthesis method of a 3, 5-diaryl-4-trifluoromethyl pyrazole derivative, which comprises the following step of: by taking aromatic aldehyde p-toluenesulfonyl hydrazone and 2-chloro-3, 3, 3-trifluoroaryl propylene as reaction substrates, potassium tert-butoxide as alkali and tetrahydrofuran as a solvent, stirring and reacting for 12 hours at 70 DEG C. The method has the advantages of simple and easily available raw materials, relatively mild reaction conditions, wide substrate universality, novel preparation process, less pollution, low energy consumption and the like.

The invention discloses a mefenpyr-diethyl impurity, a preparation method and applications thereof, wherein the molecular structural formula is represented by a formula I. The preparation method comprises: carrying out diazotization and a Japp-Klingemann reaction by using 2,4,-dichloroaniline, nitrite and ethyl 2-chloroacetoacetate as raw materials to obtain an intermediate, and carrying out a ring-closure reaction on the intermediate and ethyl methacrylate to obtain 1,5-bis(2,4-dichlorophenyl)-6-methyl-1H,5H-pyrazolo[5,1-c]-1,2,4-triazole-3,6,7a-triethyl tricarboxylate, wherein the yield reaches more than 40%. According to the invention, the method has advantages of mild reaction conditions, low energy consumption, high economic feasibility and high yield; and the substance has the application value in the influence on the efficacy of mefenpyr-diethyl by using the substance as the impurity and in the safety evaluation of the residual substance on agricultural products.

The invention provides a nitrogen-phosphorus synergist containing loach and mucus hydrolysate thereof, and a preparation method and application of the nitrogen-phosphorus synergist. The nitrogen-phosphorus synergist containing the loach and the mucus hydrolysate thereof comprises the following components in parts by weight: 30-45 parts of the loach and the mucus hydrolysate thereof, 30-60 parts ofblack chokeberry pomace, 5-15 parts of nostoc sphaeroides proteoglycan, 15-30 parts of potassium fulvate, 15-40 parts of polyaspartic acid, 1-5 parts of cyclohexylphosphoric triamide, and 0.5-5 partsof 3,4 dimethylpyrazole, 1-6 parts of sodium alpha-naphthylacetate, 3-9 parts of brassinolide and 2-5 parts of poly-gamma-glutamic acid. The planting test shows that by the nitrogen-phosphorus synergist, the yield of protected vegetables can be increased, use of nitrogen and phosphorus fertilizers is reduced, the contents of available phosphorus and available nitrogen in soil are increased, the quality of the soil can further be improved, and soil-borne diseases are inhibited.

The invention relates to a preparation method of lorlatinib. Specifically, the invention provides a preparation method of lorlatinib. According to the method, a compound 1-methyl-3-((methyl-t-butyloxycarboryl-amino) methyl)-1H-pyrazole-4-bromine-5-nitrile as shown in a formula VII and a compound 2-(t-butyloxycarboryl-amino)-3-hydroxy-5-bromopyridine as shown in a formula VI are used as raw materials and subjected to a coupling reaction, a Williamson reaction, a hydrolysis reaction, an acidolysis reaction and a condensation reaction, so as to prepare lorlatinib. The preparation method of the lorlatinib has the advantages of being short in synthesis route, simple and convenient to operate, mild in reaction condition, high in yield and the like, and is suitable for industrial production of the lorlatinib.

The invention discloses a reactive acid yellow dye for nylon and a preparation method thereof, comprising: cyanuric chloride is reacted with m-phenylenediaminedisulfonic acid by condensation reaction; excessive sodium nitrite is added to perform diazotization; then 15% 1-(2',5'-dicloro-4'-sulfo)phenel-3-methyl-5-pyrazolonem solution is added and mixed evenly, the obtained solution is adjusted by alkali solution to show weak acidic pH and performs couple reaction; finally 20% p-(beta-sulfatoethylsulfonyl)aniline solution is added, appropriate acidity and temperature are adjusted and reactive acid yellow dye is obtained when the temperature is preserved. Not only physical bond but also chemical bonding exists between the reactive acid yellow and nylon fiber, thus showing strong combining capacity. In 30-60 DEG C routine tests, the dyed fabric of invention can be washed for a plurality of times without fading and has good wet-fastness; even on the washing conditions of steaming and detergent, the fabric also shows good fastness performance and migration, bright color and high degree of exhaustion.

The invention discloses a preparation process of a polyfluoric substituted aromatic heterocycles compound. The preparation process of the polyfluoric substituted aromatic heterocycles compound comprises the steps of taking tert-butyl (3S, 4S)-3-amino-4-(3,4-difluorophenyl)piperidine-1-carboxylate p-toluene sulfonate as a raw material, carrying out dissociation, carrying out condensation reaction on the tert-butyl (3S, 4S)-3-amino-4-(3,4-difluorophenyl)piperidine-1-carboxylate p-toluene sulfonate and 2-fluro-4-(1-methyl-1H-pyrazole-5-yl) benzoic acid, then removing protecting group, and finallysalifying with L-malic acid to obtain 4-(1-methyl-1H-pyrazole-yl)-N-((3S,4S)-4-(3,4-difluorophenyl) piperidine-3-yl)-2-fluorobenzamide L-malate. The used raw material SM1 is solid, the stability is high, weighing and storage are facilitated, the shortcoming that in the prior art, IM1 easily becomes liquid, and is difficult to refine is overcome, an SM1 quality control standard is easily established on production, and raw material suppliers can provide pure SM1; and meanwhile, the chiral purity of the raw material SM1 is high, and the purity and integral yield of the final product are ensuredfrom the source.

The invention discloses a trifluoromethyl pyrazole derivative and applications thereof. The trifluoromethyl pyrazole derivative is obtained by utilizing intermolecular trifluorodiazoethane-alkyne cycloaddition reaction catalyzed by Lewis base, can be used for the cycloaddition reaction with terminal/internal alkyne; and a new approach for the synthesis of 3-trifluoromethyl pyrazole is provided. Apreparation method has the characteristics of environmental protection and simple operation, and is suitable for application and large-scale production. The invention also provides applications in preventing and treating cancers, immune system diseases, cardiovascular diseases or infectious diseases.

The invention discloses a synthesis method of high-selectivity 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol, the synthesis method comprises the following steps: taking ethyl 4, 4, 4-trifluoroacetoacetate and a methylhydrazine aqueous solution as raw materials, carrying out condensation cyclization reaction in the presence of an organic solvent and a catalyst, after the reaction is finished, filtering the reaction system, washing and drying, and obtaining the target product 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-alcohol. According to the invention, cheap raw materials and solvents are adopted, and the reagent ethanol can be generated in the reaction, so that the reaction can be carried out in the forward direction, the reaction efficiency is improved, the reaction conditions are mild, and the reaction process is easy to control; by adding the limited catalyst, the selectivity and the yield of the reaction can be further improved, the yield reaches up to 95% or above, the selectivity of the target product to the byproduct is greater than 99: 1, and the method not only ensures high-selectivity preparation of the target product, but also is relatively high in overall yield, relatively low in cost, less in environmental pollution and suitable for industrial production.

The invention relates to N-(2-pyridyl)-2-(2,4-dimethyl parazole formamido) benzamide as well as a preparation thereof and use thereof. A structural formula of the N-(2-pyridyl)-2-(2,4-dimethyl parazole formamido) benzamide is as shown in the specification. The preparation method comprises the following steps: taking o-nitrobenzoic acid as a starting material, and carrying out amidation to obtain an intermediate 2-nitrobenzamide; then, reducing nitryl into amido by use of iron powder; and finally, enabling the amido to act with the intermediate acyl chloride under the action of triethylamine, thereby acquiring a target compound N-(2-pyridyl)-2-(2,4-dimethyl parazole formamido) benzamide. The N-(2-pyridyl)-2-(2,4-dimethyl parazole formamido) benzamide has the beneficial effects that the synthesis process is simple; the acquired compound has outstanding bacteriostatic activity on rice sheath blight fungi (Rhizoctorzia solani), and has a bacteriostasis rate of 72.8% on the rice sheath blight fungi under concentration being 1000 ppm.

The present invention relates to novel active compound combinations comprising the known fungicidally active compounds N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, metalaxyl and triazole (3), which are highly suitable for controlling unwanted phytopathogenic fungi. Moreover, the invention relates to a method for the curative or preventive treatment of phytopathogenic fungi on plants or useful plants, in particular to the treatment of seed, for example seed of cereals, and not least to the treated seed itself.

The invention relates to the field of compounds, particularly to a fused ring aromatic imide derivative compound, a preparation method and applications thereof, wherein the fused ring aromatic imide derivative compound has a structure as shown in a formula I or a formula II or a formula III, and R is one selected from 3-pyrazole, 4-pyrazole and 5-methyl-3-pyrazole. According to the invention, thefused ring aromatic imide derivative compound is prepared by using a simple organic synthesis method, and can be applied to the fields of coordination chemistry, solar cells, light emitting diodes, biochemistry and the like; the preparation method has few steps, can obtain the product through one-step synthesis, is simple in operation, only involves common organic synthesis steps, and has characteristics of low production cost, cheap and easily available raw materials, high yield and simple post-treatment purification, wherein the yield is more than 80%; and the preparation method is suitablefor industrial production of fused ring aromatic imide derivative compounds.