Method of synthesizing 5-(4-chloro-phenyl)-N-hydroxy-1-(4-methoxy-phenyl)-N-methyl-1H-pyrazole-3-propionamide and pharmaceutical use
A compound, butyl technology, applied in the field of organic compound synthesis, can solve problems such as high risk and easy combustion, and achieve the effects of simple steps, high safety, and elimination of environmental pollution problems.
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[0038] (1) Synthesis of 4-chloro-γ, ε-dioxo-phenylhexanoic acid (compound of formula I)
[0039] Potassium tert-butoxide (22.10 g, 0.20 mol) was dissolved in THF (210 mL) to make a solution. Dissolve p-chloroacetophenone (13.40 g, 0.09 mol) in THF (30 mL) at a temperature of -15-10° C., and add it dropwise to the above-mentioned THF solution of potassium tert-butoxide with a constant pressure funnel within 40 minutes. React for half an hour after dropping. Succinic anhydride (10.51g, 0.11mol) was dissolved in THF (170mL) to make a solution, and was added dropwise to the above reaction solution at a temperature of -15-10°C, and the drop was completed within 3.5 hours, and the reaction was continued for 2 hours.
[0040] At room temperature, the pH value of the reaction solution was adjusted to 4-5 with dilute hydrochloric acid (40 mL) (concentrated hydrochloric acid:water=1:7, volume ratio). The reaction solution was suction-filtered, and the filter cake was washed with a sma...
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