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Magnesium and aluminum suspension and preparation process thereof

A preparation process, a technology of magnesium and aluminum, applied in the directions of liquid transportation, emulsion transportation, aluminum/calcium/magnesium active ingredients, etc., can solve problems such as no suspension found, achieve good uniformity, low production cost, increase The effect of compliance

Active Publication Date: 2022-02-11
北京鑫开元医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no suspension with magnesium plus aluminum as the active ingredient found on the market

Method used

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  • Magnesium and aluminum suspension and preparation process thereof
  • Magnesium and aluminum suspension and preparation process thereof
  • Magnesium and aluminum suspension and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Table 1

[0040] Name of raw material Weight (g) Proportion wt% Magnesium plus aluminum 5 5 hypromellose 0.05 0.05 colloidal microcrystalline cellulose 0.5 0.5 carrageenan 0.3 0.3 Sorbitol 14 (concentration 70wt%) 14 Simethicone Lotion 0.5 0.5 Dihydrochalcone 0.5 0.5 Chlorhexidine acetate 0.05 0.05 orange flavor 0.5 0.5 purified water 78.6 78.6

[0041] Preparation Process:

[0042] Step 1. Weigh each component according to the formula in Table 1.

[0043] Step 2. Add the colloidal microcrystalline cellulose to 25 mL of purified water and stir, and then pass through a high-shear emulsifier for high-shear operation for 10 minutes to obtain a colloidal microcrystalline cellulose dispersion, which is ready for use.

[0044] Step 3. Add hypromellose and carrageenan into 30 mL of boiling water, stir for 1 hour to fully swell, and obtain a mixed solution of hypromellose and carrageenan, ...

Embodiment 2

[0051] Table 2

[0052] Name of raw material Weight (g) Proportion wt% Magnesium plus aluminum 5 5 hypromellose 0.02 0.02 colloidal microcrystalline cellulose 0.8 0.8 carrageenan 0.3 0.3 Sorbitol 12 (concentration 60wt%) 12 Simethicone Lotion 0.5 0.5 Dihydrochalcone 0.5 0.5 Chlorhexidine acetate 0.05 0.05 orange flavor 0.5 0.5 purified water 80.33 80.33

[0053] Preparation Process:

[0054] Step 1. Weigh each component according to the formula in Table 2.

[0055] Step 2. Add the colloidal microcrystalline cellulose to 25 mL of purified water and stir, and then pass through a high-shear emulsifier for high-shear operation for 10 minutes to obtain a colloidal microcrystalline cellulose dispersion, which is ready for use.

[0056] Step 3. Add hypromellose and carrageenan into 25 mL of boiling water, stir for 1 hour to fully swell, and obtain a mixed solution of hypromellose and carrageenan...

Embodiment 3

[0063] table 3

[0064] Name of raw material Weight (g) Proportion wt% Magnesium plus aluminum 5 5 hypromellose 0.08 0.08 colloidal microcrystalline cellulose 0.4 0.4 carrageenan 0.2 0.2 Sorbitol 20 (concentration 70wt%) 20 Simethicone Lotion 0.5 0.5 Dihydrochalcone 0.5 0.5 Domiphene 0.003 0.003 strawberry flavor 0.5 0.5 purified water 72.817 72.817

[0065] Preparation Process:

[0066] Step 1. Weigh each component according to the formula in Table 3.

[0067] Step 2. Add the colloidal microcrystalline cellulose to 25 mL of purified water and stir, and then pass through a high-shear emulsifier for high-shear operation for 10 minutes to obtain a colloidal microcrystalline cellulose dispersion, which is ready for use.

[0068] Step 3. Add hypromellose and carrageenan into 25 mL of boiling water, stir for 1 hour to fully swell, and obtain a mixed solution of hypromellose and carrageenan, wh...

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Abstract

The invention relates to a magnesium-aluminum suspension and a preparation process thereof. The magnesium-aluminum suspension comprises magnesium-aluminum, sorbitol, a mixed suspending aid, a defoaming agent, an excipient, water and other components, and the mixed suspending aid is composed of hydroxypropyl methylcellulose, colloidal microcrystalline cellulose and carrageenan. The preparation method comprises the following steps: preparing a sorbitol solution from sorbitol, carrying out high shear on magnesium-aluminum and the sorbitol solution to form a magnesium-aluminum sorbitol dispersion liquid, preparing a mixed suspending agent and water into a mixed suspending agent dispersion liquid, and fully mixing and dispersing the magnesium-aluminum sorbitol dispersion liquid, the mixed suspending agent dispersion liquid, a defoaming agent, an excipient, water and the like to obtain the magnesium-aluminum suspension. The magnesium and aluminum suspension is good in uniformity, stable in performance and not prone to sedimentation; the magnesium and aluminum suspension is small in viscosity, and the in-vitro acid resistance of the magnesium and aluminum suspension can be maintained for a long time when the pH value of the magnesium and aluminum suspension is 3.0-5.0.

Description

technical field [0001] The invention relates to a magnesium-aluminum suspension and a preparation process thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Magnesium plus aluminum belongs to inorganic antacids (also known as stomach neutralizers), and is a hydrate of magnesium-aluminum basic salt. Magnesium plus aluminum can neutralize excessive gastric acid after oral administration, reduce gastric acidity and pepsin activity, and relieve gastric acid erosion and stimulation of gastric mucosa and ulcer surface, thereby relieving pain and promoting ulcer healing. [0003] Magnesium plus aluminum preparations currently on the market are magnesium plus aluminum chewable tablets, which are antacids used to relieve symptoms of peptic ulcer, reflux esophagitis, acute and chronic gastritis and other related diseases, such as acid reflux , epigastric pain, heartburn, abdominal discomfort, belching, bloating, etc. The main ingr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K33/06A61K47/26A61K47/38A61K47/36A61K47/34A61P1/04
CPCA61K9/10A61K9/0053A61K33/06A61K47/26A61K47/38A61K47/36A61K47/34A61P1/04
Inventor 武荣华温占勇戴信敏
Owner 北京鑫开元医药科技有限公司
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