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Microfluid driving system based on porous membrane regulation and control, and driving mode and application thereof

A drive system and porous membrane technology, applied in the direction of sterilization methods, fluid controllers, biological material sampling methods, etc., can solve the problems of high cost, inconvenient portability of fluid drive devices, and untimely response, etc., to achieve volume reduction and cost, the effect of achieving a portable fluid drive

Pending Publication Date: 2022-02-25
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above prior art, the present invention provides a microfluid drive system based on porous membrane regulation and its drive mode and application to solve the problems of the existing fluid drive devices such as inconvenient portability, high cost, and untimely response.

Method used

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  • Microfluid driving system based on porous membrane regulation and control, and driving mode and application thereof
  • Microfluid driving system based on porous membrane regulation and control, and driving mode and application thereof
  • Microfluid driving system based on porous membrane regulation and control, and driving mode and application thereof

Examples

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Effect test

Embodiment 1

[0030] A microfluidic drive system based on porous membrane regulation, such as Figure 6As shown, it includes a discarded carbon dioxide miniature compressed gas cylinder 5 with a pressure reducing valve 4 and two sets of porous membrane assemblies 8 arranged in parallel, and each set of porous membrane assemblies 8 includes three PDMS porous membranes connected in parallel through a switching valve 2 , the porosity of the porous film from top to bottom is 15.77%, 25.84%, 40.12%, the thickness is 5mm, and the area is 12mm 2 .

[0031] The above-mentioned positive pressure drive system based on porous membrane was applied to droplet generation experiments, such as Figure 6 as shown ( Figure 6 a, 6b and 6c are respectively the schematic diagram of the driving system, the schematic diagram of the droplet generation chip and the experimental result figure), and the specific implementation methods are as follows:

[0032] (1) Assembly: according to Figure 6 As shown in a, t...

Embodiment 2

[0036] A microfluidic drive system based on porous membrane regulation, such as Figure 7 As shown, it includes a discarded carbon dioxide miniature compressed gas cylinder 5 with a pressure reducing valve 4 and two sets of porous membrane assemblies 8 with switching valves 2 arranged in parallel, and each group of porous membrane assemblies 8 includes three through switching valves 2 Al connected in parallel 2 o 3 Inorganic porous membrane, the porosity of the porous membrane is 12.18%, 22.18%, 41.05% from top to bottom, the thickness is 10μm, and the area is 12mm 2 .

[0037] The above-mentioned positive pressure drive system based on porous membrane was applied to concentration gradient generation experiments, such as Figure 7 as shown ( Figure 7 a, 7b and 7c are respectively the drive system schematic diagram, the gradient generation chip schematic diagram and the experimental result figure), and the specific implementation methods are as follows:

[0038] (1) Assem...

Embodiment 3

[0042] A microfluidic drive system based on porous membrane regulation, such as Figure 8 As shown, the micro-vacuum pump 7 (kamoer, 12v), the switching valve 2 and the porous microcolumn 1 formed by the capillary glass tube filled with polystyrene beads are included, wherein the porous membrane 1 has a porosity of 11.32%, a thickness of 3mm, and an area of 3mm 2 .

[0043] The above-mentioned negative pressure drive system based on porous membrane is applied to long-term perfusion cell culture experiments, such as Figure 8 as shown ( Figure 8 a, 8b and 8c are respectively the schematic diagram of the driving system, the schematic diagram of the structure of the dynamic cell culture microfluidic chip 6 and the experimental result diagram), and the specific implementation methods are as follows:

[0044] (1) Assembly: Assemble sample bottle 3, cell dynamic culture microfluidic chip 6, waste liquid bottle 9, porous membrane 1, switching valve 2, and micro vacuum pump 7 (kam...

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Abstract

The invention discloses a microfluid driving system based on porous membrane regulation and control, and a driving mode and application thereof. The microfluid driving system comprises an air pressure source, an airflow pipeline and a porous membrane assembly; one end of the airflow pipeline is connected with the air pressure source, and the other end extends to a to-be-driven microfluid; and the porous membrane assembly comprises at least one porous membrane, and the porous membrane is integrated on the airflow pipeline. The microfluid driving system provided by the invention can be used for simply, conveniently and flexibly regulating and controlling the fluid driving pressure intensity and the fluid flow speed in a wide range, can realize portable fluid driving, and is applied to a microfluidic detection system and a chip laboratory.

Description

technical field [0001] The invention belongs to the technical field of liquid transportation, and in particular relates to a microfluid drive system based on porous membrane regulation and its application. Background technique [0002] In recent years, microfluidic technology has attracted widespread attention and been increasingly used in the fields of biology, medicine and chemistry due to its advantages such as low reagent consumption, fast analysis speed, high throughput, easy integration and automation. For microfluidic technology, microfluidic drive is the key to its application and operation. The processes of sampling, mixing, reaction, and separation involved in microfluidic analysis all involve microfluidic drive. [0003] In the application of microfluidic technology, fluid drive methods can generally be divided into two types: mechanical drive and non-mechanical drive. The mechanical drive method mainly uses the mechanical movement of the relevant parts of the pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00C12M3/00C12M1/12
CPCB01L3/50273B01L3/502784C12M23/16C12M33/04C12M29/00B01L2400/0487
Inventor 李刚白岩松刘可宇赵强
Owner CHONGQING UNIV
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