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Inactivated virus dissolving biomimetic enzyme and preparation method thereof

A biomimetic enzyme and inactivation technology, applied in antiviral agents, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as large toxic and side effects, difficult anti-HIV vaccines, and HIV easily mutated, and achieve a simple preparation method and no toxic side effects. , mild medicinal effect

Pending Publication Date: 2022-03-08
IDEAL NEW MATERIAL TECH HONGKONG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing technology cannot fundamentally cure AIDS, it has found drugs that can effectively control the transmission of HIV-using "highly effective combined antiviral therapy" to control the growth of the virus, but patients often need to take multiple drugs at the same time throughout their lives. leading to an increase in demand for anti-HIV drugs worldwide
In addition, the invention of the Hart therapy has brought hope and light to AIDS patients, but its toxic side effects are high, the price is expensive, and the long-term efficacy is still inconclusive
Research on AIDS vaccines has also made great progress, but due to the variability of HIV, anti-HIV vaccines are still difficult to use clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of deactivated AIDS virus dissolving biomimetic enzyme, described dissolving biomimetic enzyme comprises:

[0030] 150 parts of comfrey, 150 parts of astragalus, 150 parts of Dendrobium candidum, 100 parts of green tea, 100 parts of marshmallow flowers, 100 parts of dodder, 25 parts of chitosan, 10 parts of D-mannitol, and 10 parts of N-acetylneuraminic acid.

[0031] The preparation method of the above-mentioned toxin-dissolving biomimetic enzyme comprises the following steps:

[0032] (1) Take comfrey, astragalus, dendrobium candidum, green tea, hollyhock flower, and dodder in a pulverizer to pulverize fully according to the weight fraction, and sieve to obtain comfrey powder, astragalus powder, dendrobium candidum powder, green tea powder, and hollyhock pollen respectively , dodder powder;

[0033](2) The comfrey powder, astragalus powder, dendrobium officinale powder, green tea powder, marshmallow pollen, and dodder powder prepared in the above step (1) are ...

Embodiment 2

[0036] A kind of deactivated AIDS virus dissolving biomimetic enzyme, described dissolving biomimetic enzyme comprises:

[0037] 160 parts of comfrey, 160 parts of astragalus, 160 parts of Dendrobium candidum, 80 parts of green tea, 80 parts of hollyhock flower, 80 parts of dodder, 30 parts of chitosan, 6 parts of D-mannitol, and 6 parts of N-acetylneuraminic acid.

[0038] The preparation method of the above-mentioned toxin-dissolving biomimetic enzyme comprises the following steps:

[0039] (1) Take comfrey, astragalus, dendrobium candidum, green tea, hollyhock flower, and dodder in a pulverizer to pulverize fully according to the weight fraction, and sieve to obtain comfrey powder, astragalus powder, dendrobium candidum powder, green tea powder, and hollyhock pollen respectively , dodder powder;

[0040] (2) The comfrey powder, astragalus powder, dendrobium officinale powder, green tea powder, marshmallow pollen, and dodder powder prepared in the above step (1) are extract...

Embodiment 3

[0043] A kind of deactivated AIDS virus dissolving biomimetic enzyme, described dissolving biomimetic enzyme comprises:

[0044] 140 parts of comfrey, 140 parts of astragalus, 140 parts of Dendrobium candidum, 115 parts of green tea, 115 parts of marshmallow flower, 115 parts of dodder, 20 parts of chitosan, 12 parts of D-mannitol, and 12 parts of N-acetylneuraminic acid.

[0045] The preparation method of the above-mentioned toxin-dissolving biomimetic enzyme comprises the following steps:

[0046] (1) Take comfrey, astragalus, dendrobium candidum, green tea, hollyhock flower, and dodder in a pulverizer to pulverize fully according to the weight fraction, and sieve to obtain comfrey powder, astragalus powder, dendrobium candidum powder, green tea powder, and hollyhock pollen respectively , dodder powder;

[0047] (2) The comfrey powder, astragalus powder, dendrobium officinale powder, green tea powder, marshmallow pollen, and dodder powder prepared in the above step (1) are ...

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Abstract

The invention provides an inactivated virus dissolving biomimetic enzyme and a preparation method thereof, and belongs to the technical field of biology. By adjusting the proportion of lithospermum, astragalus membranaceus, dendrobium officinale, green tea, abelmoschus manihot and semen cuscutae and the proportion of chitosan, D-mannitol and N-acetylneuraminic acid, an obvious synergistic effect can be achieved, the antitoxic biomimetic enzyme has an obvious anti-human immunodeficiency virus effect, and the antitoxic biomimetic enzyme has the advantages of being natural, safe and mild in drug effect, does not have toxic or side effects, and is suitable for clinical application. The preparation method is simple, low in cost and beneficial to large-scale production, and has important significance on transmission, prevention and treatment of AIDS (Acquired Immune Deficiency Syndrome).

Description

technical field [0001] The invention belongs to the field of biological technology, and in particular relates to an inactivated virus-dissolving biomimetic enzyme and a preparation method thereof. Background technique [0002] AIDS, namely acquired immunodeficiency syndrome (Acquired Immunodeficiency Syndrome, AIDS), is a malignant infectious disease with a high lethality rate caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV, also known as AIDS virus). [0003] HIV is a retrovirus that causes a defect in the human immune system. The virus attacks and gradually destroys the human immune system, leaving the host unprotected when infected. People who become infected with HIV and die often die from secondary infections or cancer. Human immunodeficiency virus can be divided into two types: HIV-1 and HIV-2. Among them, HIV-1 and chimpanzee immunodeficiency virus (SIVcpz) are very similar in genetic composition, while HIV-2 and black white eyebrow monkey ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P31/18A61K31/198A61K31/722A61K31/047
CPCA61K36/30A61K36/481A61K36/8984A61K36/82A61K36/185A61K36/39A61K36/43A61K31/722A61K31/198A61K31/047A61P31/18A61K2236/333A61K2236/35A61K2236/39A61K2300/00
Inventor 何新桥
Owner IDEAL NEW MATERIAL TECH HONGKONG LTD