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Antibacterial heterogeneous porous membrane and preparation method thereof

A porous membrane, heterogeneous technology, used in medical science, surgery, etc., can solve the problems of infection of new tissues, poor bacteriostatic properties, poor elasticity and mechanical properties, and achieve the effect of protecting space, good elasticity and mechanical properties

Active Publication Date: 2022-03-08
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the membrane cannot selectively pass beneficial components through the membrane, and has a poor barrier effect and poor bacteriostasis
Chinese patent CN105688288A discloses the preparation of collagen-based composite oral repair film, which uses oxidized carboxymethyl chitosan to cross-link collagen to make the film have certain antibacterial properties, but the film has poor elasticity and mechanical properties
[0006] 3. There are many bacterial colonies in the oral cavity. During the wound healing process, it is easy to cause wound pollution and oral bio-adhesion, resulting in wound infection and reduction of new tissue

Method used

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  • Antibacterial heterogeneous porous membrane and preparation method thereof

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preparation example Construction

[0039] The embodiment of the present invention also relates to the preparation method of the antibacterial heterogeneous porous membrane, the method comprising the following steps:

[0040] (1) Preparation of collagen slurry: mix type I collagen and elastin, add acidic solution, stir and mix to obtain collagen slurry. Divide the collagen slurry into 3 parts for preparing loose porous layer, antibacterial dense layer and bonding.

[0041] In one embodiment of the present invention, the mass ratio of type I collagen to elastin is (70-90):(10-30). Among them, the elastin organization structure can effectively improve the elasticity and mechanical properties of the porous membrane, such as tensile strength and elastic modulus.

[0042] In one embodiment of the present invention, the acidic solution is an aqueous solution of acetic acid or phosphoric acid, with a mass concentration of 0.02-0.10 wt%. The effect of adding acidic solution is to dissolve type I collagen and elastin t...

Embodiment 1

[0061] The antibacterial heterogeneous porous membrane is prepared by the following method:

[0062] (1) Preparation of collagen slurry: 1.6 g of 90% type I collagen and 10% elastin mixture were placed in 120 mL of 0.08 wt% acetic acid aqueous solution, mechanically stirred at 20°C and 800 rpm for 3 h , to obtain a collagen slurry. The collagen slurry prepared above is divided into three parts, which are used for preparing a loose porous layer, an antibacterial dense layer and bonding.

[0063] (2) Preparation of a loose porous layer: Add 0.0005 g of EDC / NHS (molar ratio 2:1) as a cross-linking agent to 150 mL of collagen slurry, and stir at 100 rpm at room temperature under the irradiation of ultraviolet light with a wavelength of 280 nm After reacting for 6 hours, pour the reacted mixed solution into a mold for freeze-drying. The depth of the mold is 0.5 mm to obtain a loose porous layer. The loose porous layer prepared above was washed 3 times with purified water, and pla...

Embodiment 2

[0069] In step (1), 1.6 g of protein mixture contains 80% type I collagen and 20% elastin, and other steps are the same as in Example 1.

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Abstract

The invention provides an antibacterial heterogeneous porous membrane which is formed by compounding a loose porous layer and an antibacterial compact layer, and the loose porous layer and the antibacterial compact layer are bonded through collagen slurry. The porous membrane has certain antibacterial activity and proper pore size, so that specific components can be allowed to penetrate through the membrane, and autologous cells can be effectively prevented from penetrating through the membrane. Meanwhile, the porous membrane has good elasticity and tensile property. In the wound healing process after the oral surgery, the antibacterial and barrier effects can be effectively achieved, and the space required for repairing diseased and defective tissues is protected. The invention also provides a preparation method of the antibacterial heterogeneous porous membrane.

Description

technical field [0001] The invention relates to the technical field of oral medical materials, in particular to an antibacterial heterogeneous porous membrane and a preparation method of the porous membrane. Background technique [0002] Tooth loss caused by oral diseases such as periodontitis and dental caries has become a common oral disease. Surveys show that more than half of the population suffers from missing teeth. With the continuous development of science, dental implant technology has become a common method for the restoration of tooth loss. However, clinically, due to the physiological bone resorption after tooth loss and the bone tissue defect in traumatic tooth loss, some alveolar ridges are often too low. , too narrow or partially defective cases. 40% to 80% of patients suffer from insufficient bone mass. If left untreated, lateral perforation often occurs during implantation, leading to implant failure. With the clinical application of guided regeneration t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04A61L31/14A61L31/16
CPCA61L31/16A61L31/146A61L31/044A61L31/047A61L2300/404A61L2300/252
Inventor 李国雨张伟黄果孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD