Method for extracting nicotine from molecularly imprinted polymer

A technology of molecular imprinting and polymers, applied in chemical instruments and methods, other chemical processes, organic chemistry, etc., can solve the problems of high cost, low product purity, complicated steps, etc., achieve long service life, high selectivity, reduce Effect of Solvent Dosage

Active Publication Date: 2022-03-11
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above-mentioned problems in the background technology, the present invention provides a method for extracting nicotine by molecularly imprinted polymers. The present invention artificially synthesizes molecularly imprinted polymers and uses the obtained molecularly imprinted p

Method used

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  • Method for extracting nicotine from molecularly imprinted polymer
  • Method for extracting nicotine from molecularly imprinted polymer
  • Method for extracting nicotine from molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0064] Example 1

[0065] 1, the preparation of molecularly imprinted polymers (reverse suspension polymerization):

[0066] An inert gas environment, the template molecule 40.5mg of nicotine, 43mg of methacrylic acid (MAA), 36mg of acrylic acid (AA), 385mg of N, N- methylene-bis-acrylamide (BIS), 30mg ammonium persulfate ( APS) was dissolved in 10ml / 1ml water / ethanol, to give a dispersed phase; liquid paraffin 10.3g in 352ml of Span 80 was dissolved to obtain a continuous phase; and at 70 ℃, next of 400 rpm (rotation speed) speed mechanical stirring, the dispersed phase polymerization reactor was slowly added dropwise continuous phase occurs after 6 hours, the mixed solution was filtered to give the crude product molecularly imprinted polymers, acetate containing methanol volume ratio: 9 mixed solution washed molecularly imprinted polymer The crude product, obtained molecularly imprinted polymer MIP1.

[0067] Preparation Example 1 and the difference of the non-imprinted poly...

Example Embodiment

[0100] Example 2

[0101] In an inert gas environment, 40.5 mg of nicotine template molecules, 129 mg of MAA, 385 mg of BI, 30 mgAPs were dissolved in 10 ml / 1 mL of water / ethanol, resulting in dispersed phases; 2.88 g of a plate 80 is dissolved in 88 ml of liquid In paraffin, a continuous phase is obtained; then at 70 ° C, 400 rpm (rotational speed) mechanical stirring speed, the polymerization phase is slowly added to the continuous phase, and after 6 hours, the mixed solution is filtered to obtain a molecular blotting polymer. The crude product was cleaned with a mixed solution of acetic acid with a mixed solution of 1: 9 with a methanol volume ratio of 1: 9 to obtain molecular blotting polymer MIP2.

[0102] The adsorption characterization of the molecular imprinted polymer and the molecular blotting polymer prepared Flash column and performance test results are the same as in Example 1, and will not be described later.

Example Embodiment

[0103] Example 3

[0104] In an inert gas environment, 40.5 mg of nicotinic template molecules, 86 mg of MAA, 385 mg of BI, 30 mgAPs were dissolved in 10 ml / 1 mL of water / ethanol, resulting in dispersed phases; 2.88 g of a plate 80 is dissolved in 88 ml of liquid In paraffin, a continuous phase is obtained; then at 70 ° C, 400 rpm (rotational speed) mechanical stirring speed, the polymerization phase is slowly added to the continuous phase, and after 6 hours, the mixed solution is filtered to obtain a molecular blotting polymer. The crude product was cleaned with a mixed solution of acetic acid with a mixed solution of 1: 9 with a methanol volume ratio of 1: 9 to obtain molecular blotting polymer MIP3.

[0105] The adsorption characterization of the molecular imprinted polymer and the molecular blotting polymer prepared Flash column and performance test results are the same as in Example 1, and will not be described later.

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Abstract

The invention provides a method for extracting nicotine from a molecularly imprinted polymer, which is characterized in that the molecularly imprinted polymer is prepared by a reversed-phase suspension polymerization method, the prepared molecularly imprinted polymer is used for preparing a chromatographic column, and a large amount of active ingredients (nicotine) are rapidly extracted from a tobacco crude extract by a chromatographic separation technology. The solvent dosage is effectively reduced, the extraction time is shortened, and the problems of high cost, complex steps, low product purity and the like of a traditional method for extracting the active ingredient nicotine from the waste tobacco leaves are solved. And the method has universality, can be used for extracting active components in other waste tobacco leaves only by replacing template molecules, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of separation and purification of nicotine, in particular to a method for extracting nicotine by a molecularly imprinted polymer. Background technique [0002] my country is a large tobacco-growing country, and tobacco income has become an indispensable aspect of my country's economic growth. However, a large amount of waste tobacco leaves are produced every year, and its disposal is a very troublesome problem. The nicotine contained in waste tobacco leaves has high application value and is widely used in the fields of fine chemicals, pharmaceuticals, organic synthesis, national defense industry and agriculture. Therefore, separating and extracting high-purity nicotine from waste tobacco leaves to turn waste into treasure and create economic value has become a research hotspot for those skilled in the art. [0003] Traditional nicotine extraction methods mainly include ion exchange, distillation, and extra...

Claims

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Application Information

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IPC IPC(8): C08F222/38C08F220/06C08J9/26C07D401/04B01J20/26B01J20/30C08L35/00
CPCC08F222/385C08J9/26C07D401/04B01J20/268C08J2201/0424C08J2335/00C08F220/06
Inventor 薛敏牛璠孟子晖张佳杰
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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