Preparation of near-infrared quantum dot assembly structure

A quantum dot and near-infrared technology, applied in the field of medicine, can solve the problems of loss of fluorescence performance of quantum dots, poor stability, difficult purification, etc., and achieve the effects of easy repetition and promotion, stable performance and good biocompatibility.

Pending Publication Date: 2022-03-22
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, ligand replacement is a relatively early method, which is simple and easy to implement, but it has the problem of serious loss of quantum dot fluorescence performance and poor stability; although

Method used

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  • Preparation of near-infrared quantum dot assembly structure
  • Preparation of near-infrared quantum dot assembly structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Preparation of PbS quantum dots (PbS) in the second near-infrared region:

[0018] Weigh 0.04g S and dissolve in 7.5mL oleylamine, 2 The temperature was raised to 120 ° C under the condition of magnetic stirring for 20 min, then cooled to room temperature, and continued to keep flowing N 2 . Preparation of Pb precursor: weigh 2g PbCl 2 and 7.5mL oleylamine in a three-necked bottle, vacuumed to remove oxygen, and 2 The temperature was raised to 150 °C under the condition of magnetic stirring for 40 min. The reaction temperature was lowered to 70°C. Under vigorous stirring, the S precursor solution was quickly injected into the Pb precursor, and the solution in the three-neck flask quickly changed from white to black. After maintaining the reaction temperature at 70 °C for 6 minutes, pour 20 mL of n-hexane solution to stop the growth of PbS quantum dots. The prepared PbS quantum dot solution is centrifuged to remove impurities and then left to stand and purified....

Embodiment 2

[0026] (1) Preparation of PbS quantum dots (PbS) in the second near-infrared region:

[0027] Weigh 0.04g S and dissolve in 7.5mL oleylamine, 2 The temperature was raised to 120 ° C under the condition of magnetic stirring for 20 min, then cooled to room temperature, and continued to keep flowing N 2 . Preparation of Pb precursor: weigh 2g PbCl 2 and 7.5mL oleylamine in a three-necked bottle, vacuumed to remove oxygen, and 2 The temperature was raised to 150 °C under the condition of magnetic stirring for 40 min. The reaction temperature was lowered to 70°C. Under vigorous stirring, the S precursor solution was quickly injected into the Pb precursor, and the solution in the three-neck flask quickly changed from white to black. After maintaining the reaction temperature at 70 °C for 6 minutes, pour 20 mL of n-hexane solution to stop the growth of PbS quantum dots. The prepared PbS quantum dot solution is centrifuged to remove impurities and then left to stand and purified....

Embodiment 3

[0035] (1) Preparation of PbS quantum dots (PbS) in the second near-infrared region:

[0036] Weigh 0.04g S and dissolve in 7.5mL oleylamine, 2 The temperature was raised to 120 ° C under the condition of magnetic stirring for 20 min, then cooled to room temperature, and continued to keep flowing N 2 . Preparation of Pb precursor: weigh 2g PbCl 2 and 7.5mL oleylamine in a three-necked bottle, vacuumed to remove oxygen, and 2 The temperature was raised to 150 °C under the condition of magnetic stirring for 40 min. The reaction temperature was lowered to 70°C. Under vigorous stirring, the S precursor solution was quickly injected into the Pb precursor, and the solution in the three-neck flask quickly changed from white to black. After maintaining the reaction temperature at 70 °C for 6 minutes, pour 20 mL of n-hexane solution to stop the growth of PbS quantum dots. The prepared PbS quantum dot solution is centrifuged to remove impurities and then left to stand and purified....

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Abstract

The invention discloses a near-infrared quantum dot assembly structure, which is characterized in that high-light-emitting microspheres with adjustable assembly density and excellent water solubility are obtained by efficiently filling a tree-shaped silicon pore channel with near-infrared two-region PbS quantum dots. Firstly, lead chloride is used as a lead source, oleylamine is added to serve as a surface stabilizer and a solvent, and a lead precursor is obtained under inert gas and high temperature; dissolving elemental sulfur in oleylamine to obtain a sulfur precursor; and rapidly injecting the sulfur precursor into the lead precursor at a certain lead precursor temperature to obtain the oil-soluble PbS quantum dot. Secondly, preparing a central radial macroporous dendritic silicon (dSi) template by adopting a dual-surfactant method; and then, by utilizing the affinity of sulfydryl on the surface of the dSi nanosphere pore channel and the PbS quantum dots and taking dSi as an affinity template, realizing efficient assembly of the silicon pore channel from inside to outside. N-octyltrimethoxysilane/methanol/ammonia water is used as a hydrolysis system, so that silanization modification of the hydrophobic assembly is realized.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the preparation of a near-infrared quantum dot assembly structure. Background technique [0002] Due to the low background signal, deep penetrating ability and relatively small influence of ultraviolet and visible light on the structure of biological substrates, near-infrared fluorescent materials have great application prospects in biological detection and imaging. Most of the previously reported materials are concentrated in the first near-infrared region (wavelength 700-900nm), while materials in the second near-infrared region (wavelength 1000-1700nm) are rarely reported. Compared with the first near-infrared region, the second near-infrared region further reduces tissue absorption, autofluorescent light and light scattering. Among them, PbS quantum dots have a narrow band gap, a large Bohr radius, and an adjustable emission wavelength across the entire NIR-II, and are curr...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/66G01N21/64
CPCC09K11/025C09K11/661G01N21/6428G01N21/6456
Inventor 张其清敖丽娇林珊
Owner SHENZHEN PEOPLES HOSPITAL
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