Unlock instant, AI-driven research and patent intelligence for your innovation.

Biologically modified oxidized regenerated cellulose hemostatic anti-adhesion material and preparation method thereof

A technology of regenerated cellulose and biological modification, applied in the field of biomedical materials and their preparation, can solve problems such as incompatibility with protein materials and low biocompatibility.

Active Publication Date: 2022-04-08
YANCHENG INST OF TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cellulose is also a polysaccharide, due to its chemical structure, its biocompatibility with the human body is not as good as chitosan, hyaluronic acid and other substances, and it is not comparable to protein substances.
Therefore, there is a potential biocompatibility risk when pure cellulose is used for absorbable anti-adhesion in vivo

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biologically modified oxidized regenerated cellulose hemostatic anti-adhesion material and preparation method thereof
  • Biologically modified oxidized regenerated cellulose hemostatic anti-adhesion material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Step 1 (S1): Preparation of bacterial cellulose nanoslurry. Specifically, bacterial cellulose wet film (provided by Guilin Qihong Technology Co., Ltd.) was directly used, which was mechanically pulverized and acidified with 70% sulfuric acid in sequence. The volume ratio of slurry to sulfuric acid was 1:10, and the acidification time was 6 hours. The concentration of the nanocellulose slurry obtained after washing, centrifugal separation and dialysis is about 1.2g / mL, the radial dimension of the nanofiber is 200-400nm, and the transverse dimension is 20-50nm.

[0045] Step 2 (S2): Oxidation of regenerated cellulose. Specifically, the regenerated cellulose in S1 was carboxylated and formylated to increase its water solubility and reactivity. The carboxylation reaction was carried out in a TEMPO-NaBr-NaClO selective oxidation system (provided by Shanghai Macklin Company, the mass ratio of regenerated cellulose to oxidizing reagent was 10:1), mainly to oxidize C6 primary ...

Embodiment 2

[0051] Step 1 (S1): Preparation of bacterial cellulose nanoslurry. Specifically, bacterial cellulose wet film (provided by Guilin Qihong Technology Co., Ltd.) was directly used, which was mechanically pulverized and acidified with 65% sulfuric acid in sequence. The volume ratio of slurry to sulfuric acid was 1:8, and the acidification time was 6 hours. The concentration of the nanocellulose slurry obtained after water washing, centrifugal separation and dialysis is about 1.4g / mL, the radial dimension of the nanofiber is 1000-2000nm, and the transverse dimension is 50-100nm.

[0052] Step 2 (S2): Oxidation of regenerated cellulose. Specifically, the regenerated cellulose in S1 was carboxylated and formylated to increase its water solubility and reactivity. The carboxylation reaction was carried out in a TEMPO-NaBr-NaClO selective oxidation system (provided by Shanghai Macklin Company, the mass ratio of regenerated cellulose to oxidizing reagent was 10:1), mainly to oxidize C6 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Radial sizeaaaaaaaaaa
Horizontal sizeaaaaaaaaaa
Radial sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a biologically modified oxidized regenerated cellulose hemostatic anti-adhesion material and a preparation method thereof. The hemostatic anti-adhesion material comprises oxidized regenerated cellulose, polyethyleneimine PEI and collagen Col. The method comprises the following steps: dispersing oxidized regenerated cellulose ORC into water, adding EDC and NHS for activation, adding a PEI solution, and stirring for reaction to obtain a PEI modified ORC solution; then mixing with a collagen aqueous solution, adding EDC and NHS, and stirring for reaction; the hemostasis anti-adhesion material has the advantages of low crystallinity, good biocompatibility, high water absorption hemostasis rate, fast moisture absorption gelation, short in-vivo degradation period and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials and preparation thereof, in particular to a biomodified oxidized regenerated cellulose hemostatic and anti-adhesion material and a preparation method thereof. Background technique [0002] Medical practice has proved that in some open (or laparotomy) obstetrics and gynecology pelvic surgery, it is a necessary measure to introduce absorbable anti-adhesion film to help reduce the occurrence of postoperative adhesion. However, as a material that can be absorbed and degraded in the body, the primary indicator of investigation is biocompatibility. If the biomedical material used has side effects such as greater rejection with human organisms, it cannot be used as a biomedical material. [0003] The existing widely used absorbable anti-adhesion film products are mainly cellulose-based derivative products, such as regenerated oxidized cellulose (ORC) and carboxymethyl cellulose (CMC), with trade name...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/04A61L31/06A61L31/14
Inventor 吴焕岭郑成辉蒙丽娟王乃涛谢周良汪阳王宇航
Owner YANCHENG INST OF TECH