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Application of glycyrrhizic acid or glycyrrhizic acid derivative in preparation of medicine for treating retinitis

A technology of retinitis and glycyrrhizic acid, applied in the field of biomedicine, can solve the problem that the exact mechanism of retinitis is not completely clear, and achieve the effects of reducing inflammatory lesions, inhibiting activation and inflammatory response, and inhibiting infiltration

Inactive Publication Date: 2022-04-12
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The exact mechanism of the pathogenesis of retinitis is not completely clear, and the development of safe and effective targeted therapy drugs is imminent

Method used

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  • Application of glycyrrhizic acid or glycyrrhizic acid derivative in preparation of medicine for treating retinitis
  • Application of glycyrrhizic acid or glycyrrhizic acid derivative in preparation of medicine for treating retinitis
  • Application of glycyrrhizic acid or glycyrrhizic acid derivative in preparation of medicine for treating retinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] Preparation of Glycyrrhizic Acid Injection

[0021] Weigh 0.1 g of glycyrrhizic acid powder and place it in 1 ml of DMSO for static dissolution, then add the dissolved glycyrrhizic acid into 49 ml of PBS to prepare 50 ml of glycyrrhizic acid injection.

experiment example

[0023] Fifteen C57 mice (18-20g) were randomly divided into three groups: (1) retinitis group (EAU); (2) retinitis glycyrrhizic acid treatment group (EAU+GA); (3) control group (NC) : Normal C57 mice.

[0024] The animal model of retinitis mouse model is as follows: IRBP1-20 and complete Freund's adjuvant are mixed and emulsified at 1:1; each mouse in the model is subcutaneously injected with 150 μL IRBP / complete Freund's adjuvant, and then injected intraperitoneally 1 μg pertussis toxin.

[0025] The mice in the retinitis group were all retinitis model mice; the immunized retinitis model mice were treated with glycyrrhizic acid to obtain the retinitis glycyrrhizic acid treatment group; the specific treatment method was: on the first day after immunization, start giving Retinitis model mice were intraperitoneally injected with glycyrrhizic acid injection every other day for 21 consecutive days. From the 7th day after immunization, the fundus of the mice in the retinitis glyc...

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Abstract

The invention discloses an application of glycyrrhizic acid or a derivative thereof in preparation of a medicine for treating retinitis. It is found that glycyrrhizic acid or derivatives thereof or pharmaceutically acceptable salts thereof can effectively reduce fundus retina inflammation focuses, inhibit retina microglial cell activation and inflammatory response and reduce and inhibit retina tissue damage and inflammatory cell infiltration, has the potential of being developed into retinitis treatment drugs, and can be applied to treatment of retinitis. Patients can be prevented from being troubled by diseases such as hypertension and hyperosteogeny caused by hormone medicines.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of glycyrrhizic acid or its derivatives in the preparation of medicines for treating retinitis. Background technique [0002] Glycyrrhizic acid (Glycyrrhizic acid, GA) is one of the main components of the traditional Chinese medicine licorice, the molecular formula is C 42 h 62 o 16 . Glycyrrhizic acid and its derivatives have a wide range of pharmacological activities, and their activity research mainly includes: (1) for the treatment and prevention of gastric ulcer, duodenal ulcer and common cold; (2) play an anti-allergic effect by reducing the level of IL-4 Function; (3) inhibit tumor progression; (4) affect the synthesis of cholesterol by accelerating the excretion of bile acids to reduce the level of cholesterol in plasma; (5) have antiviral activity on Flaviviridae; (6) for the treatment of various Skin diseases such as psoriasis and viti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P27/02A61P9/10
Inventor 迟玮付云昭
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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