Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition of cortex fraxini extract and borneol as well as preparation method and application of pharmaceutical composition

A technology of composition and extract, which is applied in the direction of drug combination, pharmaceutical formula, active ingredients of hydroxyl compounds, etc., can solve the problems such as the development and efficacy evaluation of the total coumarin of phoenix bark, and achieve good therapeutic effect and improve inhibition The effect of inhibiting the formation of new lymphatic vessels

Active Publication Date: 2022-04-19
SHANGHAI UNIV OF T C M
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total coumarins of quincetin are considered to be the main active components of quincetrin, and currently for high-purity total coumarins of quincetrin (75-85wt% of total coumarin content; the content of quincetrin A, quincetrin B, fencetrin and fencetrin and be 55-65wt%) preparation technology has not been reported yet, and the modern preparation development and drug effect evaluation of the total coumarin of fenugreek have a great influence

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition of cortex fraxini extract and borneol as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition of cortex fraxini extract and borneol as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition of cortex fraxini extract and borneol as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 Static adsorption method screening macroporous resin

[0067] Take by weighing 100g of Cortex chinensis medicinal material, add 8 times the amount (800ml) of 75% ethanol and heat and reflux to extract twice, each time for 2 hours, the extract is recovered under reduced pressure to ethanol and concentrated to 133ml, which is the Pitt officinalis extract.

[0068] 25g of different types of macroporous resins (D101, D301R, HPD100, ADS-7, HD450, HPD500) were used for static adsorption with 10ml of Qinpi extract, and the adsorption rate was calculated.

[0069] Adsorption rate (%)=(total coumarin concentration in stock solution-total coumarin concentration in filtrate after adsorption)×filtrate volume / total coumarin content in stock solution.

[0070] The results showed that: D101, D301R, HPD100, ADS-7, HD450, and HPD500 above seven kinds of macroporous resins had higher than 50% adsorption rates of aureticin, aureticin, aureticin and aureticin, among which D301...

Embodiment 2

[0071] The preparation of embodiment 2 Cortex chinensis extract

[0072] Weigh 100g of Pittia chinensis medicinal material, add 8 times the amount (800ml) of 75% ethanol and heat and reflux to extract twice, each time for 2 hours, the extract is recovered under reduced pressure to recover ethanol and concentrated to 133ml (0.75g crude drug / ml). The sample loading volume is 0.8 times the column volume (BV), and the treated ADS-7 macroporous resin (washed with 95% ethanol until there is no turbidity, and then washed with distilled water until there is no alcohol smell) at a volume flow rate of 2BV / h, 2 times The column volume was eluted with water to remove impurities, and then eluted with 6 times the column volume of 25% ethanol, discarding the first 1 times the column volume eluate, collecting the 2-6 times the column volume of the 25% ethanol eluate, and reducing pressure Concentrate and dry to obtain the extract of bark bark.

[0073] Determination of active ingredients in ...

Embodiment 3

[0089] The preparation of embodiment 3 Qin bark extract

[0090] Weigh 100g of the medicinal material of Cortex chinensis, add 8 times the amount of 75% ethanol and heat and reflux to extract twice, each time for 2 hours, the extract is recovered under reduced pressure to recover ethanol and concentrated to 133ml (0.75g crude drug / ml). The sample loading volume is 0.8 times the column volume (BV), and the treated D301R macroporous resin is passed through the treated D301R macroporous resin at a volume flow rate of 2 BV / h, and impurities are eluted with 2 times the column volume of water, and then 7 times the column volume of 30% ethanol is used for elution , Discard the first 1 column volume eluate, collect the 30% ethanol eluate of the 3rd to 7th column volume, concentrate and dry under reduced pressure to obtain the extract of Pittia chinensis.

[0091] Measured according to the method of the above-mentioned embodiment 2, the total coumarin content in the bark extract is 77.6 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a pharmaceutical composition of a cortex fraxini extract and borneol as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises 3.6-116 parts by weight of the cortex fraxini extract and 1 part by weight of borneol. The cortex fraxini extract mainly takes cortex fraxini total coumarin as an active ingredient, and the cortex fraxini total coumarin comprises aesculin, aesculetin, fraxin and fraxetin; the content of cortex fraxini total coumarin in the cortex fraxini extract is 75-85 wt% or above, the sum of the contents of aesculin, aesculetin, fraxin and fraxetin in the cortex fraxini extract is 55-65 wt% or above, and the content ratio of aesculin to aesculetin to fraxetin is (30.0-40.0): (2.0-4.0): (20.0-30.0): 1. The cortex fraxini extract is prepared by taking traditional Chinese medicine cortex fraxini decoction pieces or a cortex fraxini medicinal material as a raw material and adopting a combined process of alcohol extraction, macroporous resin column purification and the like. The composition disclosed by the invention can be used for remarkably inhibiting the formation of newborn lymphatic vessels in corneas and has a relatively good treatment effect on diseases such as corneal injury.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition of bark bark extract and borneol, its preparation method and its application in the preparation of corneal injury medicine. Background technique [0002] The traditional Chinese medicine Qinpi is the dried bark or bark of Fraxinus rhynchophylla Hance, Fraxinus chinensis Roxb., Fraxinus szaboana Lingelsh. or Fraxinus stylosa Lingelsh. of Oleaceae plants. Stripped in spring and autumn, dried in the sun. It is mainly produced in Northeast China, Hebei, Henan, Inner Mongolia, Shaanxi, Shanxi and other places. It has the functions of clearing heat and dampness, reducing astringency, stopping dysentery, stopping belt, and improving eyesight. It is used for damp-heat diarrhea, red and white vaginal discharge, red and swollen eyes, Raw pannus. Qinpi contains various chemical components such as coumarins, phenols, saponins, tannins, and alkaloids. Coumarin compound...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/63A61K31/045A61P27/02
CPCA61K36/63A61K31/045A61P27/02A61K2236/333A61K2236/55A61K2236/51A61K2300/00Y02A50/30
Inventor 张建革张彤丁越朱玉莹兰金帅汪飞云林国强季光
Owner SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com