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Quaternary ammonium salt composition for killing microorganisms as well as preparation method and application of quaternary ammonium salt composition

A technology of quaternary ammonium salt and composition, which is applied in the field of quaternary ammonium salt composition for killing microorganisms and its preparation, can solve problems such as poor inactivation effect, explosion, and safety risks, and achieve safe and easy-to-kill treatment objects. Killing effect, effect with a wide range of applications

Pending Publication Date: 2022-04-29
GUANGZHOU BLUE MOON IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The researchers believe that the compound composition of didecyldimethylammonium chloride and lauryl polyoxyethylene ether (C12E8) can act on the lipids and / or proteins on the envelope of enveloped viruses, thus affecting its Very good inactivation, while hydrophilic virus shells do not have an envelope, so they are poorly inactivated
[0016] In short, regarding quaternary ammonium salt disinfection products, those skilled in the art generally believe that the quaternary ammonium salt (used alone, or compound non-ionic surfactant) system is less effective in inactivating non-enveloped hydrophilic viruses; and Quaternary ammonium salts need to be used in combination with a large amount of low-flash point raw materials (such as ethanol), which is easy to cause explosions and poses safety risks

Method used

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  • Quaternary ammonium salt composition for killing microorganisms as well as preparation method and application of quaternary ammonium salt composition
  • Quaternary ammonium salt composition for killing microorganisms as well as preparation method and application of quaternary ammonium salt composition
  • Quaternary ammonium salt composition for killing microorganisms as well as preparation method and application of quaternary ammonium salt composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-17 and comparative example 1-3

[0212] The compositions of the quaternary ammonium salt composition Examples 1-17 and Comparative Examples 1-3 are shown in Table 1-3. After preparing the quaternary ammonium salt composition in proportion to each component, the stock solution of the quaternary ammonium salt composition was used to carry out the virus inactivation test test. The test method is:

[0213] The inactivation test of poliovirus was carried out with reference to the method of ""Technical Specifications for Disinfection" (2002 Edition), 2.1.1.10 Virus Inactivation Test". The degree of pollution of the target will affect the killing effect. Generally, 3% (W / V) bovine serum albumin stock solution is added during the experimental test. This condition represents a polluted scene, or even a severely polluted scene. Alternatively, for disinfection or cleaning only of cleaning items or instruments, a 0.3% (w / v) bovine serum albumin stock solution can be used. Unless otherwise specified, the test results of ...

Embodiment 2

[0224] Example 2, adjusting the pH to 12.02 with sodium metasilicate has a good inactivation effect on poliovirus, and the inactivation logarithm value is 5.28.

Embodiment 3

[0225] In Example 3, adjusting the pH to 11.60 with monoethanolamine has a good inactivation effect on poliovirus, and the inactivation logarithm value is 4.33.

[0226] Example 4 In the sodium hydroxide system of Comparative Example 2, potassium chloride was additionally added (the molar number of potassium ions was the same as in Example 1), and the inactivation logarithmic value of poliovirus was increased from 0.50 to 3.55, indicating that potassium ions There should be synergy. Example 5 Add ion / ligand sodium methylglycine diacetate with chelating effect to the sodium hydroxide system of Comparative Example 2, and the inactivation logarithm of poliovirus is increased from 0.50 to 3.72, indicating that methylglycine Sodium diacetate chelation acts synergistically in enhancing poliovirus inactivation.

[0227] It can be seen that in order to reduce the negative impact of sodium ions introduced by the alkaline agent of sodium source on the inactivation of poliovirus, potass...

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Abstract

The invention relates to the technical field of disinfection, and particularly discloses a quaternary ammonium salt composition for killing microorganisms as well as a preparation method and application of the quaternary ammonium salt composition. The quaternary ammonium salt composition contains or does not contain sodium free ions; when the quaternary ammonium salt composition contains sodium free ions, the mole number of the sodium free ions in the quaternary ammonium salt composition is less than 0.1 mol / 100g; when the quaternary ammonium salt composition contains sodium free ions and the mole number of the sodium free ions is greater than or equal to 0.001 mol / 100g, the quaternary ammonium salt composition also contains potassium free ions and ions / ligands with chelation. According to the invention, a quaternary ammonium salt synergistic system is adopted, ion species are added in a targeted manner, and a non-quaternary ammonium salt surfactant can be compounded, so that the quaternary ammonium salt composition has a very good killing effect on various microorganisms, and especially has very effective inactivation on hydrophilic viruses represented by poliovirus; and moreover, the method is safe to a processed object and wider in application range.

Description

technical field [0001] The invention belongs to the technical field of disinfection, and in particular relates to a quaternary ammonium salt composition for killing microorganisms, a preparation method and application thereof. Background technique [0002] "Disinfection Technical Specifications" (2002 Edition) pointed out that it is generally believed that the order of the sensitivity of microorganisms to disinfection factors from high to low is: [0003] (1) Lipophilic viruses (viruses with lipid membranes, also known as enveloped viruses), such as hepatitis B virus, influenza virus, etc.; [0004] (2) Bacterial propagules; [0005] (3) Fungi; [0006] (4) Hydrophilic viruses (viruses without a lipid envelope, also known as non-enveloped viruses), such as hepatitis A virus, polio virus, etc. [0007] Therefore, the ability to inactivate hydrophilic viruses is often used to evaluate the level of microbial killing of compositions; among them, poliovirus is more difficult t...

Claims

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Application Information

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IPC IPC(8): A01N33/12A01N25/04A01P3/00A01P1/00
CPCA01N33/12A01N25/04
Inventor 龙海华周碧红郑翔龙
Owner GUANGZHOU BLUE MOON IND
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