Application of flavone C-glycoside compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome

A technology of acute respiratory distress and flavonoid carbon glycosides, which is applied in the field of pharmaceutical research and development, can solve the problems of low curative effect and the dosage of drugs for suppressing pulmonary edema, and achieve the goal of low dosage, suppressing pulmonary edema, and relieving the symptoms of severe and critical patients Effect

Pending Publication Date: 2022-05-06
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the object of the present invention is to solve the problem that the drugs in the prior art cannot inhibit pulmonary edema while anti-inflammatory and have high dosage and low curative effect, so as to provide a kind of flavonoid carbon glycosides in the preparation of prophylaxis or Use of drugs in the treatment of acute lung injury and / or acute respiratory distress syndrome

Method used

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  • Application of flavone C-glycoside compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome
  • Application of flavone C-glycoside compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome
  • Application of flavone C-glycoside compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 compound 1-1~1-3

[0046]

[0047] Commercially available Desmodium styraci foLium (Latin name: Desmodium styraci foLium, (Osb.) Merr.) 10kg, chopped, extracted with 40% ethanol aqueous solution (20L) at room temperature for 10 hours, filtered, and the residue was extracted with 15L ethanol at room temperature 6 hours, filtered, combined the two filtrates, and concentrated under reduced pressure to obtain a crude extract. The obtained crude extract was subjected to column chromatography using D101 macroporous resin, successively eluted with pure water, 10% ethanol aqueous solution, 25% ethanol aqueous solution, 50% ethanol aqueous solution, and 95% ethanol aqueous solution, each gradient eluted 4BV, collected The eluate was concentrated under reduced pressure with 10% ethanol and 25% ethanol respectively to obtain extracts Fr.A and Fr.B.

[0048] The extract Fr.A was subjected to column chromatography using a reverse-phase C18 chromat...

Embodiment 2

[0052] The preparation of embodiment 2 compound 2-1~2-9

[0053]

[0054] Weigh 30kg of corn silk (purchased from Anhui Bozhou Medicinal Materials Market) and cut it into pieces, add 240kg of 60% ethanol solution by volume, stir and extract at 60°C for 3 hours, filter out the ethanol, add 180kg of 60% volume percent ethanol solution to the residue, Stir and extract at 60°C for 3 hours, filter, combine the filtrates, concentrate at 50°C to obtain 3830g of extract, and extract the concentrate with chloroform, ethyl acetate, and water-saturated n-butanol solution for 4 times in order to obtain 336g of chloroform layer and 610g of ethyl acetate layer , n-butanol layer 1598g, water layer 1286g, get n-butanol extract and concentrate to no alcohol. Put n-butanol extract on AB-8 (macroporous resin) chromatographic column (column diameter 6cm * height 60cm, column volume 1.7L), use volume fraction as 0%, 10%, 30%, 50%, 75%, Gradient elution with 95% ethanol aqueous solution, each g...

Embodiment 3

[0063] The preparation of embodiment 3 compound 3-1~3-11

[0064]

[0065]

[0066] Weigh 20kg of Ziziphus jujube seeds, pulverize (particle size 40-60 mesh), add 70% methanol aqueous solution in volume percentage and extract twice at 60°C, each time for 2h, add 80kg volume percentage in 70% methanol water solution each time, and combine the extracts , concentrated to no alcohol (solid content 1832g), extracted 3 times with petroleum ether and n-butanol respectively, 5L each time, to obtain the n-butanol part (761g) and separated it through a silica gel column. : 1, 10:1, 8:1, 6:1, 4:1, 2:1, 1:1 mixture of chloroform and methanol as eluent for gradient elution, each gradient has 3 column volumes, Eight components Fr. 1-8 were obtained.

[0067] Among them, Fr.3 (the elution fraction of chloroform and methanol with a volume ratio of 10:1) was concentrated under reduced pressure to remove the solvent and then separated with a C18 column. The volume ratios were 30:70, 40:6...

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Abstract

The invention relates to the technical field of medicine research and development, in particular to application of a flavone C-glycoside compound in preparation of medicine for preventing or treating acute lung injury and / or acute respiratory distress syndrome, the flavone C-glycoside compound has a structure shown in the following formula, R1-R8 are defined in the specification, and the flavone C-glycoside compound has a structure shown in the specification. The flavone C-glycoside compound provided by the invention can obviously inhibit inflammatory response, inhibit release of inflammatory factors and reduce the content of inflammatory factors in alveolar lavage fluid and serum, and also can obviously inhibit pulmonary edema, reduce generation of pulmonary effusion and reduce wet weight of lungs; the increasing degree of the ratio of wet weight to dry weight of lung caused by acute lung injury is inhibited, so that the effects of resisting inflammation and inhibiting lung edema are achieved.

Description

technical field [0001] The invention relates to the technical field of medical research and development, in particular to the application of a flavonoid carbon glycoside compound in the preparation of drugs for preventing or treating acute lung injury and / or acute respiratory distress syndrome. Background technique [0002] Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is a common clinical critical illness with a high mortality rate, which seriously threatens the lives of critically ill patients. According to statistics, more than 10% of ALI patients need to be admitted to the intensive care unit for treatment, and the fatality rate is as high as 32%-55%. In recent years, it has gradually increased, which has significantly increased the social and economic burden. It can be compared with chest tumors, ARDS, bronchial asthma or myocardial infarction etc. on a par. The basic pathophysiological change of ALI / ARDS is non-cardiogenic pulmonary edema caused b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P11/00A61P31/04A61P31/12A61P31/14A61P7/08A61P31/22A61P31/16A61P31/20
CPCA61K31/7048A61K31/352A61P11/00A61P31/04A61P31/12A61P31/14A61P7/08A61P31/22A61P31/16A61P31/20
Inventor 温尧林郑钱凤李彩萍
Owner CATCH BIO SCI & TECH
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