Polyether sulfone membrane with separation/adsorption dual functions and preparation method thereof

Abstract

The invention discloses a polyethersulfone membrane with separation / adsorption dual functions and a preparation method thereof, and solves the problems of single function, low purification precision and the like in the field of vaccine purification in the existing membrane technology. According to the technical scheme, adsorption functional particles are uniformly dispersed in a polyethersulfone membrane matrix, cells and a virus culture solution are in contact with the adsorption functional particles in the membrane after being filtered through membrane holes, and target antigen components are adsorbed and enriched; a hydrophilic macromolecule is adopted as a pore-forming additive, so that the hydrophilic and separation properties of the membrane are synchronously improved; the polyethersulfone membrane for vaccine purification is obtained.

Description

technical field

[0001] The invention relates to a polyethersulfone membrane with dual functions of separation / adsorption and a preparation method thereof, belonging to the field of membrane materials. Background technique

[0002] Vaccine is the application of traditional methods or biotechnology such as genetic engineering, targeting pathogens or their related proteins, polysaccharides or nucleic acids, directly or indirectly through the carrier after immunization into the body, can induce specific cellular immunity, so that the body can obtain The immunity to prevent the disease has been widely used in the prevention and treatment of the disease. The removal rate of the vaccine impurities after simple purification is not high, which will directly affect the product quality of the vaccine and cause the vaccine to have relatively large side effects after clinical use. Therefore With the continuous development of my country's vaccine industry and the deepening of people's under...