Polyether sulfone membrane with separation/adsorption dual functions and preparation method thereof

A polyethersulfone membrane and dual-function technology, applied in the field of membrane materials, can solve the problems of low purification precision, complex components, and single function

Pending Publication Date: 2022-05-13
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The membrane separation method has the advantages of no phase change, low energy consumption, and no pollution. It has been widely used in vaccine purification in recent years. However, the cell and virus culture fluid involved in vaccine production is a complex biological system, and the components in the system are complex. The application of membrane technology in this field has problems such as single function and low purification precision. Therefore, in order to obtain vaccine products with higher purity, multi-stage membrane integration or coupling application with traditional processes is often required

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The mass percent formulation design of bifunctional polyethersulfone membrane casting solution is: 16wt% polyethersulfone; 16wt% 201×7 strongly basic styrene anion exchange resin particles (polyethersulfone / anion exchange resin=50 / 50) , The average particle size of the resin powder is 4.5 μm; 4wt% polyvinylpyrrolidone and 64wt% N, N dimethylacetamide.

[0016] The process of manufacturing the bifunctional polyethersulfone membrane is as follows: first add 8g of resin particles into 32g of DMAc and stir. After the dispersion is uniform, add 2g of PVP respectively. After the solid is completely dissolved, add 8g of PES in several times. After adding PES, the solution is Stir at 60°C for 4 to 12 hours; after the dissolution and dispersion are complete, ultrasonic degassing at room temperature for 1 to 3 hours to prepare a casting solution; manually scrape the casting solution on a glass plate to form a flat film with a thickness of 0.20 to 0.30mm Afterwards, it is solidifi...

Embodiment 2

[0018] The mass percent formulation design of bifunctional polyethersulfone membrane casting solution is: 18wt% polyethersulfone; 20wt% 001×4 strongly acidic styrene cation exchange resin particles, resin powder average particle size 15 μm: 2wt% polyvinyl alcohol and 60wt% %dimethylformamide. The process of manufacturing bifunctional polyethersulfone membrane is as follows: first add 10g of resin particles into 30g of DMF and stir. After the dispersion is uniform, add 1g of PVA respectively. After the solid is completely dissolved, add 9g of PES several times. After adding PES, the solution is Stir at 60°C for 4 to 12 hours; after the dissolution and dispersion are complete, ultrasonic degassing at room temperature for 1 to 3 hours to prepare a casting solution; manually scrape the casting solution on a glass plate to form a flat film with a thickness of 0.20 to 0.30mm Afterwards, it is solidified and shaped in a coagulation bath at 20-30° C. to obtain the bifunctional polyeth...

Embodiment 3

[0020] The mass percentage formula design of the bifunctional polyethersulfone membrane casting liquid is: 16wt% polyethersulfone; 10wt% D201 macroporous strongly basic styrene-based anion exchange resin particles, the average particle size of the resin powder is 3 μm; 10wt% polyethylene alcohol and 64 wt% N,N dimethylacetamide.

[0021] The process of manufacturing the bifunctional polyethersulfone membrane is as follows: first add 5g of resin particles into 32g of DMAc and stir. After the dispersion is uniform, add 5g of PVA respectively. After the solid is completely dissolved, add 8g of PES in several times. After adding PES, the solution is Stir at 60°C for 4 to 12 hours; after the dissolution and dispersion are complete, ultrasonic degassing at room temperature for 1 to 3 hours to prepare a casting solution; manually scrape the casting solution on a glass plate to form a flat film with a thickness of 0.20 to 0.30mm Afterwards, it is solidified and shaped in a coagulation...

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Abstract

The invention discloses a polyethersulfone membrane with separation / adsorption dual functions and a preparation method thereof, and solves the problems of single function, low purification precision and the like in the field of vaccine purification in the existing membrane technology. According to the technical scheme, adsorption functional particles are uniformly dispersed in a polyethersulfone membrane matrix, cells and a virus culture solution are in contact with the adsorption functional particles in the membrane after being filtered through membrane holes, and target antigen components are adsorbed and enriched; a hydrophilic macromolecule is adopted as a pore-forming additive, so that the hydrophilic and separation properties of the membrane are synchronously improved; the polyethersulfone membrane for vaccine purification is obtained.

Description

technical field [0001] The invention relates to a polyethersulfone membrane with dual functions of separation / adsorption and a preparation method thereof, belonging to the field of membrane materials. Background technique [0002] Vaccine is the application of traditional methods or biotechnology such as genetic engineering, targeting pathogens or their related proteins, polysaccharides or nucleic acids, directly or indirectly through the carrier after immunization into the body, can induce specific cellular immunity, so that the body can obtain The immunity to prevent the disease has been widely used in the prevention and treatment of the disease. The removal rate of the vaccine impurities after simple purification is not high, which will directly affect the product quality of the vaccine and cause the vaccine to have relatively large side effects after clinical use. Therefore With the continuous development of my country's vaccine industry and the deepening of people's under...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/02B01D69/14B01D67/00B01J41/09
CPCB01D71/68B01D69/02B01D69/147B01D67/0011B01D67/0013B01D67/0016B01J41/09B01D2325/12B01D2325/36
Inventor 张玉忠叶卉李泓
Owner TIANJIN POLYTECHNIC UNIV
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