Guiding film and preparation method thereof

A technology of guiding film and positioning part, applied in the field of oral cavity, can solve the problems of slow repair speed and single function of biofilm, and achieve the effect of good positioning, speeding up repair speed, good material toughness and strength

Pending Publication Date: 2022-05-17
无锡领缔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the prior art, the present invention provides a guide film and its preparation method, which solves the problems of single function and slow repair speed of the existing biofilm

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A guide film, the guide film is made of pure titanium, and the guide film includes a main body, a channel, a positioning part and a fixing part, the channel is used for liquid to pass through, the positioning part is used for positioning relative positions, the The fixing part is used to cooperate with the positioning structure to realize positioning; the main body has a composite coating of polydopamine-anticoagulant substance and biologically active substance, and the anticoagulant substance is antithrombin;

[0030] The bioactive substance includes a small molecule bioactive substance, which is minocycline.

Embodiment 2

[0032] A guide film, the guide film is made of titanium alloy, and the titanium content of the guide film is 65%. The guide film includes a main body, a channel, a positioning part and a fixing part, the channel is used for liquid to pass through, the positioning part is used to realize relative position positioning, and the fixing part is used to cooperate with the positioning structure to realize positioning; The main body has a composite coating of polydopamine-anticoagulant substance and bioactive substance, and the anticoagulant substance is heparin; the bioactive substance includes small molecular bioactive substance, which is dexamethasone.

Embodiment 3

[0034]A guide film, the guide film is made of pure titanium. The guide film includes a main body, a channel, a positioning part and a fixing part, the channel is used for liquid to pass through, the positioning part is used for positioning relative positions, and the fixing part is used to cooperate with the positioning structure to realize positioning; the The main body has a composite coating of polydopamine-anticoagulant substances and bioactive substances, and also includes fibronectin, which is used to connect the polydopamine and the anticoagulant substances, and the anticoagulant substances include antithrombin, heparin cofactor- II. Thrombin regulatory protein, protein C; the biologically active substances include small molecular biologically active substances, which are small molecular peptides, and the small molecular peptides are Arg-Gly-Asp peptides and collagen mimic peptides.

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PUM

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Abstract

The invention provides a guide film and a preparation method thereof, the guide film is made of a titanium material with good biocompatibility, the surface of the guide film is provided with a channel (2), a positioning part (3) and a fixing part (4), and the guide film has good material toughness and strength and good positioning and fixing effects; the titanium film body (1) is a polydopamine-anticoagulant substance and bioactive substance composite coating which is gradually released and absorbed by a human body after being in contact with the human body, has the effects of resisting coagulation and promoting tooth growth, and accelerates the repair speed; moreover, the micromolecular active substances are low in cost, more micromolecular active substances can be loaded on the repair membrane with the same area, rejection reaction is not easy to cause, controllable release can be realized, and the defects that the cost is high when long-chain bone morphogenetic proteins such as BMP-2 and BMP-7 are used in the prior art, the loading capacity on the repair membrane with the same area is low, and the repair membrane is difficult to release are overcome. And bone tumors may be caused after long-term use.

Description

technical field [0001] The invention relates to the field of oral cavity technology, in particular to a guiding membrane and a preparation method thereof. Background technique [0002] GBR (guided bone regeneration) guided bone regeneration technology refers to the use of barrier membrane properties to prevent fibroblasts from the surrounding soft tissue, allowing osteoblasts on the bone surface to have enough time to proliferate, and finally achieve the purpose of tissue regeneration and directional repair. The technical principle is mainly based on the different characteristics of the migration speed of various tissue cells. The artificial membrane with micropores or autologous periosteum is fixed between the soft tissue and the bone defect to form a barrier to prevent the fast-migrating connective tissue cells and epithelial cells from entering the bone defect area, thereby creating an environment for the dominant growth of bone tissue, so that Osteoblasts preferentially...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/04A61L31/10A61L31/16A61L33/00
CPCA61L31/022A61L31/10A61L31/16A61L31/047A61L33/0082A61L33/0011A61L2300/412A61L2300/42A61L2300/61
Inventor 崔雪玲
Owner 无锡领缔生物科技有限公司
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