Preparation method and application of magnetic temperature-sensitive molecularly imprinted polymer based on eutectic solvent system

A low eutectic solvent and molecular imprinting technology, applied in chemical instruments and methods, analytical materials, material separation, etc., can solve problems such as few reports on identification characteristics and lack of research on stimuli responsiveness, so as to improve adsorption capacity and reuse. High sex, quick separation effect

Pending Publication Date: 2022-05-17
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis of MIPs using deep eutectic solvent systems as functional monomers is still in its infancy, and there are few reports on its recognition properties, especially the lack of research on stimuli responsiveness.

Method used

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  • Preparation method and application of magnetic temperature-sensitive molecularly imprinted polymer based on eutectic solvent system
  • Preparation method and application of magnetic temperature-sensitive molecularly imprinted polymer based on eutectic solvent system
  • Preparation method and application of magnetic temperature-sensitive molecularly imprinted polymer based on eutectic solvent system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] N-isopropylacrylamide (NIPAM) and (3-acrylamidopropyl)trimethylammonium chloride (APTMAC) were mixed at a molar ratio of 1:1 and heated at 80 °C for 1 h to form a homogeneous transparent liquid .

Embodiment 2

[0037] Weigh 1.0 g of graphite and 1.2 g of potassium nitrate, mix well, add 46 mL of chilled concentrated sulfuric acid (98%), and stir for 30 min in an ice-water bath. Slowly add 6.0 g of potassium permanganate to the above mixed solution, and continue stirring in an ice-water bath for 15 min. Remove the ice-water bath, raise the temperature of the reaction system to 35 °C, stir for 1 h, then slowly add 90 mL of ultrapure water, raise the temperature of the reaction system to 98 °C, and continue stirring for 30 min; then slowly pour 200 mL of The reaction temperature was controlled at 98 °C in hot ultrapure water. Next, add 6 mL of hydrogen peroxide (30%) dropwise until the color of the solution changes from dark brown to bright yellow; centrifuge while hot, and wash the centrifuged precipitate three times with 20 mL of hydrochloric acid (5%) and 200 mL of ultrapure water until the supernatant is neutral and free of SO 4 2- residue, graphene oxide (GO) was obtained after ...

Embodiment 3

[0043] Based on the relationship between the peak area of ​​HPLC and the concentration of the target analyte in the actual sample, three matrix-matched calibration curves were obtained. Rhein (RH), glycyrrhizinic acid (GA) and aristolochic acid I (AAI) were respectively in In the range of 0.05-8 mg / L, 0.5-25 mg / L and 0.04-8 mg / L, there was a good linear relationship, the correlation coefficient was between 0.9091 and 0.9904, and the detection limits for RH, GA and AAI were 16.67 and 363.64, respectively and 37.52 μg / L.

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Abstract

The invention discloses a preparation method and application of a magnetic temperature-sensitive molecularly imprinted polymer based on a deep eutectic solvent system, and belongs to the technical field of functional material preparation. The N-isopropylacrylamide/(3-acrylamidopropyl) trimethyl ammonium chloride eutectic solvent system is used as a functional monomer, so that the adsorption capacity of an imprinted product is improved, and the reusability is relatively high. The molecularly imprinted polymer is used as a dispersive solid-phase extraction adsorbent, and is combined with a high performance liquid chromatography to establish a novel high-selectivity separation and enrichment method for rhein in a semen cassiae sample. In order to further prove the applicability of the molecular imprinting technology, another two magnetic temperature-sensitive molecularly imprinted polymers are prepared by adopting the eutectic solvent system as a functional monomer, and can be used for efficient analysis of triterpenoid saponin compounds and aristolochic acid substances; the application value of the magnetic temperature-sensitive molecularly imprinted polymer based on the eutectic solvent system in complex sample analysis is disclosed.

Description

technical field [0001] The invention relates to a preparation method and application of a magnetic temperature-sensitive molecularly imprinted polymer based on a deep eutectic solvent system, and belongs to the technical field of functional material preparation. Background technique [0002] Molecular imprinting technology (MIT) is developed on the basis of simulating the specific binding principle of enzyme-substrate or antibody-antigen in nature, and refers to obtaining a target compound (template molecule or Molecularly imprinted polymers (IMPs) with “molecular memory”. The elution process of MIPs prepared by traditional methods is often accompanied by incomplete removal of template molecules, destruction of recognition sites, and large consumption of organic solvents. Surface imprinting technology immobilizes the molecular imprinted layer on or close to the surface of the carrier (such as magnetic nanoparticles, graphene oxide, silica, chitosan, etc.), which reduces the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F220/60C08J9/26C08K9/10C08K3/04B01J20/26B01J20/30G01N30/02
CPCC08F220/54C08F220/606C08J9/26C08J9/009G01N30/02B01J20/268C08J2333/24
Inventor 万益群熊辉煌万昊郭岚范庸徐梦佳郭娴
Owner NANCHANG UNIV
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