Construction and application of rapid quality detection method for motherwort particles

A detection method and particle quality technology, which is applied in the construction and application field of the rapid detection method for the quality of motherwort granules, can solve the problems of high performance liquid chromatography, such as long detection time, low inspection efficiency, and complicated pretreatment, to achieve on-site analysis , shorten the detection cycle, expand the effect of coverage

Pending Publication Date: 2022-05-20
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT +1
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Problems solved by technology

Sample pretreatment is complicated, time-consuming, labor-intensive, and costly, and the detection time of high-performance liquid chromatography is relatively long, which reduces the efficiency of inspection work

Method used

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  • Construction and application of rapid quality detection method for motherwort particles
  • Construction and application of rapid quality detection method for motherwort particles
  • Construction and application of rapid quality detection method for motherwort particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 Determination of each index content of motherwort granule

[0054] Determination of stachydrine hydrochloride content:

[0055] According to the determination method of stachydrine hydrochloride under the item of motherwort granules in the 2020 edition of "Chinese Pharmacopoeia".

[0056] Chromatographic conditions and system suitability test Use strong cation exchange bonded silica gel as filler (SCX-strong cation exchange resin column); use acetonitrile-0.05mol / L potassium dihydrogen phosphate-phosphoric acid (15:85:0.15) as mobile phase ; The detection wavelength is 192nm. The number of theoretical plates is calculated based on the peak of stachydrine hydrochloride and should not be less than 2000.

[0057] Preparation of reference substance solution Take an appropriate amount of stachydrine hydrochloride reference substance, accurately weigh it, add methanol to make a solution containing 0.1mg per 1ml, and obtain.

[0058] Preparation of the test sol...

Embodiment 2

[0071] Embodiment 2 Leonurus granule spectral collection

[0072] Take different batches of samples, pour them into the sample tanks, flatten and compact the samples with matching tank covers, scan in the spectral range of 1100-2300nm, the scanning interval is 1.0nm, and the average number of scanning is 300 times. Each sample is collected 3 times, and the sample spectrum is obtained, such as Figure 5 shown.

Embodiment 3

[0073] Example 3 Leonurus granule spectral pretreatment

[0074] Before building a model, it is necessary to eliminate the influence of factors such as noise and baseline drift on spectral acquisition. Using the spectral processing program in the SNAP software, the original spectrum was preprocessed with the first-order differential 9-point smoothing method (Savitzky-Golay) to eliminate the spectral baseline shift and drift caused by factors such as color differences. Such as Figure 6 shown.

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Abstract

The invention relates to the field of medicine detection, in particular to construction and application of a rapid quality detection method for motherwort granules. According to the method, the AOTF-NIR technology is utilized, the NIR model of stachydrine hydrochloride, leonurine hydrochloride and moisture indexes in the motherwort granule finished product is established, tedious sample treatment is not needed, the content of multiple indexes in the finished product can be simultaneously and rapidly predicted, and the prediction result is accurate. According to the method provided by the invention, the detection period is shortened, the detection cost is reduced, and field analysis can be realized. And a rapid and efficient detection method is provided for quality control of the motherwort granules. Compared with a traditional pharmacopoeia method, the method has the advantages that on the basis of ensuring the accuracy, the analysis efficiency is greatly improved, the product quality can be quickly and efficiently detected, and the safety, the stability and the effectiveness of the product quality are favorably ensured.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to the construction and application of a rapid detection method for the quality of motherwort granules. Background technique [0002] Motherwort granules are composed of motherwort single herbs, which are recorded in the "Chinese Pharmacopoeia", have the effect of promoting blood circulation and regulating menstruation, and are used for irregular menstruation and postpartum lochia caused by blood stasis. The blood time is too long; postpartum uterine involution is incomplete, see the above syndrome. [0003] As a fast and non-destructive green analysis technology, near-infrared (NIR) spectroscopy has the characteristics of fast analysis, simple sample processing, and no consumption of reagents. In recent years, near-infrared spectroscopy, as an indirect analysis technique, has been used in the content determination of medicinal ingredients, identification of natural medicines, identif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N30/02
CPCG01N21/359G01N30/02G01N2030/027G01N2201/129Y02A50/30
Inventor 边雨宋德库曲佳乐高陆佟志军邹慧朱子聪
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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