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Controllable sterilizing composite hydrogel as well as preparation method and application thereof

A composite hydrogel and gel technology, applied in bandages, medical science, etc., can solve problems such as application limitations

Pending Publication Date: 2022-05-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When NIPAM hydrogel is used as a drug release carrier, it shows obvious advantages in phototherapy. It is mainly used in photodynamic therapy, photothermal therapy and other treatment methods. However, the critical temperature of a single NIPAM hydrogel is about 33 ° C. Relatively limited, so the introduction of the second monomer acrylamide (AM) is required to regulate

Method used

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  • Controllable sterilizing composite hydrogel as well as preparation method and application thereof
  • Controllable sterilizing composite hydrogel as well as preparation method and application thereof
  • Controllable sterilizing composite hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of NIPAM / AM photothermal gel:

[0029] Weighed 0.096 gN-isopropyl acrylamide monomer with 0.004 g of acrylamide monomer, and 0.003 g of N, N-methylenebis acrylamide dissolved in an aqueous solution of 2 mL LNFs@CuS, ultrasonic stirring, through the nitrogen removal solution, and then add 25 μL of 10% ammonium persulfate solution, stirred evenly after adding 10 μL of N, N, N, tetramethylethylenediamine, poured into the mold (1 cm * 1 cm * cm) In the medium polymerization reaction for 6 hours, after the end of the polymerization reaction, washed and dried, to obtain NIPAM / AM photothermal water gel, recorded as LNFs@CuS / NIPAM / AM hydrogel.

[0030] (2) Preparation of controlled sterilization of composite hydrogels:

[0031] By dry soaking method, 0.03g NIPAM / AM photothermal gel was placed in 5mL concentration of 8μM bee venom peptide solution for 48h, to be fully expanded after removal, placed in deionized water soaked for 4h, the surface of the bee venom peptid...

Embodiment 2

[0036] (1) Preparation of NIPAM / AM photothermal gel:

[0037] Weighed 0.2 gN-isopropyl acrylamide monomer with 0.006 g of acrylamide monomer, and 0.003 g of N, N-methylene biaceamide dissolved in 5 mL of 1 mM LNFs@CuS aqueous solution, stirred ultrasound, through nitrogen to remove oxygen from the solution, and then added 50 μL of 10% ammonium persulfate solution, stirred evenly after adding 15 μL of N, N, N, N, tetramethylethylenediamine, poured into the mold (1 cm * 1 cm * cm) Medium polymerization reaction for 10 hours, after the end of the polymerization reaction washed, dried, to get NIPAM / AM photothermal gel, recorded as LNFs@CuS / NIPAM / AM hydrogel.

[0038] (2) Preparation of controlled sterilization of composite hydrogels:

[0039] By dry immersion method, 0.05g NIPAM / AM photothermal gel was placed in 10mL concentration of 2μM bee venom peptide solution for 48 h, to be fully expanded after removal, soaked in deionized water for 4 h, the surface of the bee venom peptid...

Embodiment 3

[0041] (1) Preparation of NIPAM / AM photothermal gel:

[0042]Weighed 0.09gN-isopropyl acrylamide monomer with 0.005g of acrylamide monomer, and 0.003g of N, N-methylenebis acrylamide dissolved in 4mL of 1mM LNFs@CuS aqueous solution, ultrasonic stirring, through nitrogen removal solution, and then add 20 μL of 10% ammonium persulfate solution, stir well and add 5 μL of N, N, N, N, tetramethylethylenediamine, pour into the mold (1cm*1cm*cm) In the medium polymerization reaction for 5 hours, after the end of the polymerization reaction, washed and dried, to obtain NIPAM / AM photothermal water gel, denoted as LNFs@CuS / NIPAM / AM hydrogel.

[0043] (2) Preparation of controlled sterilization of composite hydrogels:

[0044] By dry soaking method, 0.04g NIPAM / AM photothermal gel was placed in 7mL concentration of 5μM bee venom peptide solution for 48h, to be fully expanded after extraction, put into deionized water soaked for 4h, the surface of the bee venom peptide solution was removed, ...

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Abstract

The invention provides a controllable sterilizing composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel preparation. According to the preparation method, a photo-thermal agent LNFs coated CuS and N-isopropylacrylamide / acrylamide are copolymerized to generate photo-thermal hydrogel, then the photo-thermal hydrogel is dried and mixed with a melittin solution to be soaked, and finally the controllable sterilization composite hydrogel is obtained. The controllable sterilization composite hydrogel is good in biocompatibility, strong in interaction with bacteria, good in controllability and capable of rapidly killing the bacteria in a short time.

Description

Technical field [0001] The present invention belongs to the field of hydrogel preparation technology, specifically relates to a controllable sterilization of composite hydrogel and preparation method and application thereof. Background [0002] Infection is a common problem in chronic wounds and one of the main reasons why wounds are difficult to heal, and the common way to treat wound infection is to use wound dressings to avoid wound infection, while traditional excipients will adhere to each other with the wound, causing secondary injury, and hydrogel dressings avoid these problems. [0003] N-Isopropyl acrylamide (NIPAM) hydrogel is a hydrophilic three-dimensional network structure polymer material that can be swelled in water without dissolving, and is a temperature-sensitive smart hydrogel. The minimum critical temperature of N-isopropyl acrylamide hydrogel is around 33 ° C, when the temperature rises above 33 ° C, the properties of the NIPAM hydrogel will change, and its v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F220/54C08F220/56C08F222/38C08J3/075
CPCA61L26/008A61L26/0066A61L26/0014A61L26/0004A61L26/0085A61L26/0047C08F220/54C08J3/075A61L2300/252A61L2300/41A61L2300/404C08L33/24C08L89/00C08F220/56C08F222/385
Inventor 苏宪浩刘磊冯永海孙彤彤
Owner JIANGSU UNIV
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