Fluorescent probe for environment detection as well as preparation method and application of fluorescent probe

A fluorescent probe, environmental detection technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of difficult to deal with the background interference of complex samples, time-consuming detection methods, expensive precision instruments, etc., to achieve high sensitivity , the preparation method is simple, the selectivity is good

Pending Publication Date: 2022-05-27
ZHONGDA TESTING (HUNAN) CO LTD
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The invention provides a fluorescent probe for environmental engineering monitoring and detection and its preparation method and application to solve the problem that the current existing detection methods take a long time, involve com

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  • Fluorescent probe for environment detection as well as preparation method and application of fluorescent probe
  • Fluorescent probe for environment detection as well as preparation method and application of fluorescent probe
  • Fluorescent probe for environment detection as well as preparation method and application of fluorescent probe

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Example Embodiment

[0033] Example 1:

[0034] The molecular structural formula of the fluorescent probe of this embodiment is shown in formula (1):

[0035] In the formula, X is Cl.

[0036] The preparation method of the fluorescent probe of this embodiment includes the following steps:

[0037] S1. Compound B (2-picolinoyl chloride, added in an amount of 141 mg, 1.0 mmol) and a catalyst (triethylamine, added in an amount of 0.69 mL, 5.0 mmol) were added to anhydrous bisulfite of compound A (359 mg, 1.0 mmol). In methyl chloride (10 mL) solution, react at room temperature at 25 °C for 2 h to obtain a mixed solution; wherein the molecular structure of compound A is shown in formula (2):

[0038] In the formula, X is Cl.

[0039] S2. The mixed solution was evaporated to remove the solvent, and then purified by silica gel chromatography (the eluent was dichloromethane), and the collected solid was the fluorescent probe (389 mg of product, 84% yield). The fluorescent probe was subjected to nu...

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Abstract

The invention discloses a fluorescent probe for environment detection and a preparation method and application thereof.The fluorescent probe has the structural formula shown in the formula (1), is prepared from a compound A and a compound B through synthesis, is stable in optical performance (the probe can be stably stored at the room temperature for six months or above, and the spectral property of the probe is kept unchanged), high in sensitivity and high in copper ion recognition capacity, and can be used for detecting copper ions. During detection, the solution is changed from yellow to red, naked eye recognition can be realized, the selectivity is good, the response speed is relatively high (the response time is 5 minutes), the response range is 0.1-10 [mu] mol.L <-1 >, the detection limit is low (34nM, a method based on 3 times of blank sample standard deviation given by the International Pure and Application Chemical Combination), and the method can be used for detecting copper ions in a water body and a biological system; the preparation method is simple, raw materials are easy to obtain, and the synthesis yield is high.

Description

technical field [0001] The invention relates to the technical field of chemical analysis and detection, in particular to a fluorescent probe used for environmental detection and a preparation method and application thereof. Background technique [0002] Copper is the third most essential trace element in the human body and plays a very important role in many physiological processes, such as maintaining the functional structure of proteins, participating in cellular respiration, gene expression and related metalloenzyme catalysis reactions. On the other hand, abnormal copper content and metabolic disorders can lead to oxidative stress responses associated with a series of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, prion disease, etc.). The U.S. Environmental Protection Agency stipulates that the safe limit value of copper ions is 1.3ppm (20μmol·L -1 ). In view of the important physiological and pathological functions of copper ions, it is ...

Claims

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Application Information

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IPC IPC(8): C07D213/79C07D213/803C09K11/06G01N21/64
CPCC07D213/79C07D213/803C09K11/06G01N21/643G01N21/6428C09K2211/1007C09K2211/1029G01N2021/6417
Inventor 郭慧宇夏旭伟唐建林朱盛沛张雅南
Owner ZHONGDA TESTING (HUNAN) CO LTD
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