Hydrogen molecule therapeutic agents for restoring brain function after TBI injury

Abstract

The invention discloses a hydrogen molecule therapeutic agent for recovering brain functions after TBI injury, and the therapeutic agent consists of hydrogen and oxygen, the volume percent concentration of the hydrogen is 5-95%, and the volume percent concentration of the oxygen is 5-95%. The therapeutic agent can alleviate neuroinflammation reaction of TBI afterbrain tissues and peripheral systems through inhalation administration to play a neuroprotective role, which is shown in that leucocytes, lymphocytes, monocytes, neutrophils and microglia in peripheral blood are reduced to different degrees, meanwhile, CD16 positive cells are reduced, CD206 positive cells are further increased, and the TBI afterbrain tissues and peripheral system neuroinflammation reaction are reduced to different degrees. And the neuroprotective and therapeutic effects of the microglial cell M1-to-M2 are exerted by promoting phenotypic transformation of the microglial cell M1-to-M2.

Description

technical field [0001] The invention relates to a hydrogen molecule therapeutic agent for restoring brain function after TBI injury, and belongs to the technical field of medicine. Background technique [0002] TBI (Traumatic brain injury, TBI) is a traumatic brain injury caused by external forces. [0003] Approximately 500,000 people in the United States suffer severe head injuries each year, and approximately 80,000 of these TBI patients face lifelong functional failure. There are more than 50,000,000 TBI patients in the world every year, and China has more TBI patients than most countries in the world, and the TBI population mortality rate is about 13 cases per 100,000 people. TBI has a very high mortality rate and is the leading cause of death and disability among young people today. This makes TBI a major public health problem. [0004] At present, about 80%-94% of traumatic brain injuries are mild or moderate brain injuries, and the survival rate of patients after ...

AI Technical Summary

Problems solved by technology

[0008] When the present invention studies the recovery of hydrogen gas on TBI damage, it is found that further increasing the concentration of hydrogen gas to treat the damage does not achieve the result that the higher the hydrogen gas concentration, the better the therapeutic effect. It is limited to the neutralization or conversion of free radical molecules in the TBI damage area, and because the reduction of free radicals does not only have a positive effect on the recovery of the body, free radicals also play a role in the body, such as killing invading bacteria , immune function, angiogenesis, vasodilation, neurotransmission, etc. Therefore, high-concentration pure hydrogen inhalation did not show a better healing effect than low-concentration pure hydrogen inhalation

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