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Traditional Chinese medicine compound preparation for treating neurogenic bladder and preparation method thereof

A technology of compound preparations and traditional Chinese medicines, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as inability to fundamentally regulate bladder function and poor therapeutic effect, and achieve High practicability, excellent moisture-proof performance, and convenient transportation and storage

Active Publication Date: 2022-07-08
山西白求恩医院(山西医学科学院华中科技大学同济医学院附属同济医院山西医院山西医科大学第三医院山西医科大学第三临床医学院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For this disease, acupuncture, traditional Chinese medicine application, traditional Chinese medicine preparation and other means are generally used in the prior art to treat the disease, but the current treatment effect is not good, and it is impossible to fundamentally regulate the bladder function and treat the disease in a targeted manner; based on this situation, this The application discloses a traditional Chinese medicine compound preparation for treating neurogenic bladder and its preparation method, and proposes a non-toxic, safe and excellent therapeutic effect scheme based on the theory of traditional Chinese medicine

Method used

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  • Traditional Chinese medicine compound preparation for treating neurogenic bladder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Take 10 parts of Poria, 15 parts of psyllium, 6 parts of black medicine, 3 parts of amber, 30 parts of astragalus, 20 parts of Atractylodes, 10 parts of Alisma, 10 parts of mallow seeds, 6 parts of Tongcao, 10 parts of talc, 15 parts of Achyranthes, crushed and passed through a 20-mesh sieve, then added water, decocted and extracted for 3 times, 2 hours each time, mixed with the decoction liquid, filtered and then the filtrate was collected and concentrated under reduced pressure at 80 °C to a relative density of 1.25-1.26 , dried at 60°C, and pulverized to obtain extract powder;

[0036] (2) Take chitosan and acetic acid aqueous solution, mix evenly, adjust pH to 4.5, add carboxymethyl chitosan solution and polyphosphate solution, and react to obtain chitosan particles; The mass ratio of polysaccharide and polyphosphate is 15:1:2;

[0037] Take extract powder, hydroxypropyl methylcellulose, β-cyclodextrin, calcium stearate and magnesium stearate, mix evenly, use e...

Embodiment 2

[0042] (1) Take 15 parts of Poria, 20 parts of psyllium, 10 parts of black medicine, 5 parts of amber, 35 parts of astragalus, 25 parts of Atractylodes, 12 parts of Alisma, 15 parts of mallow seeds, 10 parts of Tongcao, 10 parts of talc, 15 parts of Achyranthes, crushed and passed through a 20-mesh sieve, then added water, decocted and extracted for 3 times, 2 hours each time, mixed with the decoction liquid, filtered and then the filtrate was collected and concentrated under reduced pressure at 80 °C to a relative density of 1.25-1.26 , dried at 60°C, and pulverized to obtain extract powder;

[0043] (2) Take chitosan and acetic acid aqueous solution, mix evenly, adjust pH to 4.5, add carboxymethyl chitosan solution and polyphosphate solution, and react to obtain chitosan particles; The mass ratio of polysaccharide and polyphosphate is 15:1:2;

[0044] Take extract powder, hydroxypropyl methylcellulose, β-cyclodextrin, calcium stearate and magnesium stearate, mix evenly, use...

Embodiment 3

[0049] (1) Take 5 parts of Poria, 10 parts of psyllium, 4 parts of black medicine, 2 parts of amber, 35 parts of astragalus, 15 parts of Atractylodes, 5 parts of Alisma, 8 parts of mallow seeds, 5 parts of Tongcao, 14 parts of talc, 20 parts of Achyranthes, crushed and passed through a 20-mesh sieve, then added water, decocted and extracted for 3 times, 2 hours each time, mixed with the decoction liquid, filtered and the filtrate was collected, and concentrated under reduced pressure at 80 °C to a relative density of 1.25-1.26 , dried at 60°C, and pulverized to obtain extract powder;

[0050] (2) Take chitosan and acetic acid aqueous solution, mix evenly, adjust pH to 4.5, add carboxymethyl chitosan solution and polyphosphate solution, and react to obtain chitosan particles; The mass ratio of polysaccharide and polyphosphate is 15:1:2;

[0051] Take extract powder, hydroxypropyl methylcellulose, β-cyclodextrin, calcium stearate and magnesium stearate, mix evenly, use ethanol ...

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Abstract

According to the scheme, poria cocos, semen plantaginis, radix astragali, rhizoma atractylodis macrocephalae, rhizoma alismatis, chingma abutilon seeds and other components are subjected to compatibility, all prescription components are screened on the basis of the traditional Chinese medicine theory, and the traditional Chinese medicine compound preparation is obtained after multiple tests. The medicine treatment can be effectively carried out on the neurogenic bladder. According to the traditional Chinese medicine compound preparation for treating the neurogenic bladder and the preparation method of the traditional Chinese medicine compound preparation, all prescription components are screened on the basis of the traditional Chinese medicine theory, and reasonable compatibility is carried out, so that the traditional Chinese medicine compound preparation for treating the neurogenic bladder in a targeted mode is obtained. In addition, no adverse reaction occurs during actual clinical verification, the medicine safety meets the standard, and the medicine is excellent in moisture resistance after being coated, convenient to transport and store and high in practicability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for treating neurogenic bladder and a preparation method thereof. Background technique [0002] Vesicourethral dysfunction caused by damage to the central nervous system or peripheral nerves that control urination is called neurogenic bladder. There are many causes, such as cerebrovascular accident, craniocerebral tumor, hydrocephalus with normal pressure, cerebral palsy, intellectual disability, basal ganglia disease, multiple system atrophy, multiple sclerosis, spinal cord disease, intervertebral disc disease and spinal stenosis. Or due to diabetes, alcohol abuse, drug abuse, other uncommon neuropathy: porphyria, sarcoidosis, etc.; one of the most common symptoms is dysuria or urinary retention. [0003] Acupuncture, traditional Chinese medicine plastering, traditional Chinese medicine preparations and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/16A61K47/36A61K47/32A61K47/10A61K47/12A61K47/42A61K47/38A61K47/40A61P13/10A61P25/00A61K33/12A61K35/10
CPCA61K36/076A61K36/68A61K36/54A61K35/10A61K36/481A61K36/284A61K36/884A61K36/185A61K36/25A61K33/12A61K36/21A61P13/10A61P25/00A61K9/5036A61K9/5052A61K9/5089A61K9/5031A61K9/5026A61K9/5015A61K9/5047A61K2300/00Y02A50/30
Inventor 张昱张嘉轩
Owner 山西白求恩医院(山西医学科学院华中科技大学同济医学院附属同济医院山西医院山西医科大学第三医院山西医科大学第三临床医学院)