Preparation method of aluminum phosphate adjuvant

Abstract

The invention provides a preparation method of an aluminum phosphate adjuvant, which comprises the following steps: respectively dissolving potassium chloride, sodium chloride, sodium dihydrogen phosphate and sodium bicarbonate in distilled water, mixing and dissolving, diluting with distilled water, dissolving calcium chloride in a test tube, dropwise adding the calcium chloride solution in the test tube into the solution to obtain a mixed solvent, and standing for layering; the ozone reaction utilizes a large amount of hydroxyl free radicals and nascent oxygen generated in the ozone reaction to indirectly oxidize inorganic matters and organic matters in water, and enters into cells of bacteria to oxidize intracellular organic matters, so that sterilization and disinfection are achieved, and ozone can be quickly and automatically decomposed into oxygen or single oxygen atoms due to poor stability, so that the water quality is improved. The single oxygen atoms can be automatically combined into oxygen molecules, no toxic residues exist, the technological difficulty of manufacturing the aluminum phosphate adjuvant is reduced through the sterilization method, and the preparation cost of the aluminum phosphate adjuvant is reduced.

Description

technical field [0001] The invention relates to a preparation method of an aluminum phosphate adjuvant, belonging to the technical field of medicines. Background technique [0002] Vaccine compositions may contain one or more adjuvants. An "adjuvant" is a substance that is incorporated into or injected simultaneously with an antigen and that non-specifically enhances the immune response generated. By maintaining adequate antibody levels in the administered population, the resulting immune response lasts longer. For practical and economical reasons, such prophylactic immunization needs to be achieved by administering the minimum amount of antigen and using the minimum amount of antigen compatible with effective immunization injections. These adjuvants can be inorganic in nature such as alum, such as aluminum phosphate and aluminum hydroxide most commonly used in human vaccines, and organic adjuvants such as squalene; [0003] And from the 1930s, aluminum salts were widely ...

AI Technical Summary

Problems solved by technology

[0004] Chinese invention patent application number: 201010123850.2 discloses an aluminum phosphate adjuvant and its preparation method, using a peristaltic pump to mix the mixed solution of 0.06mol / L aluminum chloride and 0.06mol / L sodium dihydrogen phosphate and 0.5mol / L strong base The solutions are pumped into the reactor at the corresponding flow rate and stirred, and then the aluminum phosphate adjuvant solution is obtained by static precipitation and dissolution. However, this method needs to maintain a sterile environment during the production process, and has relatively high requirements for the production process, and the production has high cost. shortcoming

[0005] Chinese invention patent application number: 201711387856.9 discloses a preparation method of an aluminum phosphate adjuvant, in which the resuspension process is carried out by a magnetic stirrer, the surface charge and particle size of the aluminum phosphate adjuvant tend to be stable, and the pH value is closer to that of human body fluids pH value, but this method processes the solution multiple times through replacement and resuspension, the production process is cumbersome and has the disadvantage of complex process, so it is particularly important to design a new low-cost preparation method