Transdermal drug introduction structure, preparation method thereof and transdermal drug introduction system

Abstract

The invention discloses a transdermal drug introduction structure, a preparation method thereof and a transdermal drug introduction system.The transdermal drug introduction structure comprises a sound conducting film layer and a microstructure array layer arranged on the sound conducting film layer, and the microstructure array layer comprises a plurality of soluble microstructure units; the components of the soluble microstructure unit comprise functional components; the diameter of each soluble microstructure unit is gradually reduced from the root part close to the sound conducting film layer to the end part far away from the sound conducting film layer; and the ratio of the diameter of the root part of each soluble microstructure unit to the diameter of the end part of each soluble microstructure unit is 4-60. Effective components can be directly and rapidly dissolved in the corium layer of the deep part of the skin and fully permeate, so that the curative effect is enhanced.

Description

technical field [0001] The invention relates to the technical field of percutaneous drug introduction and medical devices, and more particularly, to a percutaneous drug introduction structure, a preparation method thereof, and a percutaneous drug introduction system. Background technique [0002] The skin is divided into two layers, the epidermis and the dermis: the epidermis is the superficial structure of the skin, like the outer coat of the skin, mainly composed of keratinocytes, which are divided into five layers: the stratum corneum, the transparent layer, the granular layer, the spinous layer, and the basal layer. The role of metabolism and protection of the dermis; the dermis is located under the epidermis, between the epidermis and the subcutaneous tissue, composed of dense connective tissue, divided into papillary layer and reticular layer. [0003] Transdermal introduction refers to the absorption of cosmetic ingredients, drugs, etc. through the skin into the human...

AI Technical Summary

Problems solved by technology

However, the barrier function of the stratum corneum also limits the transdermal absorption efficiency of beauty ingredients and drugs, making it difficult for functional ingredients to enter the dermis of the skin to achieve the best effect

[0005] At present, the methods of transdermal introduction mainly include: first, apply cosmetic ingredients and drugs directly to the skin, but the ingredients mainly stay in the stratum corneum of the epidermis, and the absorption is poor, and the effect is not ideal; second, the electric stimulation transdermal introduction technology , which is a physical penetration enhancement method, the principle is: the electric pulse acts on the skin surface, causing the skin to produce hydrophilic channels or electroporation effects, and beauty ingredients, drugs, etc. penetrate into the skin through hydrophilic channels or pores, which can improve skin absorption. effect; third, ultrasonic percutaneous introduction technology, which is also a physical penetration-enhancing method, the principle is: ultrasonic waves act on the skin surface, causing cavitation effects in skin care products applied to the skin surface, disrupting the lipids in the stratum corneum. The ordered molecular

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