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Polyurethane compositions salified with biguanide

A technology of composition and polyurethane, applied in polyurea/polyurethane coatings, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of low solubility

Pending Publication Date: 2022-08-02
LUBRIZOL ADVANCED MATERIALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorhexidine free base is not soluble in water or alcohols and cannot be impregnated in sufficient quantities due to low solubility in solvent systems

Method used

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  • Polyurethane compositions salified with biguanide
  • Polyurethane compositions salified with biguanide
  • Polyurethane compositions salified with biguanide

Examples

Experimental program
Comparison scheme
Effect test

example

[0138] The following example provides an illustration of this topic. These examples are non-exhaustive and are not intended to limit the scope of the subject matter.

[0139] testing method

[0140] AATCC TM147

[0141]AATCC (American Association of Textile Chemists and Colorists) TM147 - Antibacterial Activity: Parallel Scribing is a qualitative screening test used to determine the bacteriostatic (antimicrobial) activity of diffusible antimicrobials on treated textile surfaces. The scope of the test method is to determine bacteriostatic (proliferation and growth inhibition) activity by diffusion of antimicrobial agents through agar. The test sample (textile) was brought into intimate contact with a nutrient agar surface that had been previously streaked (parallel streak) with an inoculum of the test organism. After 24 hours of incubation, bacteriostatic activity was demonstrated by the appearance of distinct areas of disrupted growth below and to the sides of the test m...

example 7

[0188] Regarding Example 7, although growth occurred on the textile surface, a zone of inhibition was still created in the surrounding medium.

[0189] Table 3 reports the results of samples tested according to AATCC TM147, prepared as described above and shown below. Example 18 included Salt 1 and was not leached. Example 19 included Salt 1 and was leached in DM water as described above. Example 20 included salt 14 and was not leached. Example 21 included Salt 14 and was leached in DM water as described above.

[0190] Table 3 indicates whether each example has growth (yes or no) and zones of inhibition ("zones" in mm) as per AATCCTM147 using Klebsiella pneumoniae ("K.p.") and Staphylococcus aureus ("S.a." )test.

[0191] table 3

[0192]

[0193] Table 4 reports the results of samples tested according to AATCC TM147, prepared as described above and shown below. Example 22 included Salt 15 and was not leached. Example 23 included salt 16 and was not leached. Exampl...

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Abstract

The present subject matter relates to a polyurethane composition comprising a polyurethane having at least one free acid group salified with the biguanide free base.

Description

technical field [0001] The present subject matter relates to polyurethane compositions having at least one acid group that forms a salt with a biguanide (e.g., biguanide) free base compound. Background technique [0002] There is an ever-increasing interest in compositions that impart antimicrobial properties to products. Preventing microbial build-up and growth has grown into a multi-billion dollar industry. Some pathogenic bacteria have evolved resistance to most, if not all, currently available antibiotics on the market. These drug-resistant bacteria pose a challenge to the healthcare industry: in 2019, one in 20 patients contracted a healthcare-associated infection due to direct exposure to pathogenic bacteria in the hospital setting. The U.S. Centers for Disease Control and Prevention (CDC) estimates that the annual economic impact of these healthcare-associated infections is $28-34 billion. Additionally, in the food industry, recalls related to bacterial infections ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D175/04C08G18/08C08G18/12C08L75/04C08G18/75C08G18/34C08G18/66C08G18/32A61K31/155A61L27/18A61L27/54A61L29/16
CPCC09D175/04C08L75/04C08G18/0823C08G18/12C08G18/755C08G18/758C08G18/348C08G18/6692C08G18/3231A61L29/16A61L31/16A61L31/10A61L29/106A61L2300/404A61L2300/206
Inventor A·V·鲁伯宁D·韦伯N·波拉麦迪A·克里恩
Owner LUBRIZOL ADVANCED MATERIALS INC