Double-layer conductive microneedle patch for treating subcutaneous tumor and preparation method and application thereof

Abstract

The invention relates to the technical field of biomedical materials, in particular to a double-layer conductive microneedle patch for treating subcutaneous tumors and a preparation method and application thereof.The double-layer conductive microneedle patch is composed of a conductive microneedle substrate without a target drug and a double-layer microneedle tip containing the target drug, and the microneedle tip is prepared from an easily-soluble polymer matrix; the micro-needle substrate and the part, close to the substrate, of the micro-needle tip are prepared from a degradable polymer matrix and a conductive polymer material, so that the micro-needle has excellent biocompatibility and has no potential irritation and immunogenicity; the substrate and the part, close to the substrate, of the microneedle tip are made of a conductive polymer material, so that good conductivity is achieved, cell membrane permeability is improved through electroporation, and the biological agent or medicine absorption rate is increased; the proliferation of tumor cells is effectively inhibited; through the microneedle technology, target medicine can be intensively distributed at the tip of the microneedle, the local effective medicine concentration is improved, and the medicine cost is saved; the method has the advantages of high precision, large scale, economy and high efficiency.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a double-layer conductive microneedle patch for treating subcutaneous tumors and a preparation method and application thereof. Background technique [0002] Subcutaneous tumors are tumors that grow under the skin. Subcutaneous tumors are divided into benign tumors and malignant tumors. Benign tumors are characterized by slow growth, clear boundaries, and complete capsule. The more common subcutaneous tumors are cystic tumors with fluid inside. Subcutaneous malignant tumors are characterized by rapid growth, unclear boundaries, and burrs. They are generally solid tumors without a complete capsule, and have abundant blood flow inside. Benign subcutaneous tumors can be cured by surgical resection. Malignant subcutaneous tumors can generally be cured by extended surgical resection if they can be found, diagnosed and treated early, and the tumor does not spread and metas...

AI Technical Summary

Problems solved by technology

These methods have some disadvantages: the risk of surgery itself and the aesthetic and functional damage of the face caused by resection; the expansion of the range of radiotherapy damages the maxillofacial glands; poor targeting of chemotherapy drugs, low bioavailability, and drugs in unwanted Accumulate in the surrounding organs of the body and be quickly cleared in the blood, resulting in reduced overall efficacy

However, as a drug delivery system, microneedles can only deliver drugs to the subcutaneous area, but cannot directly deliver drugs to cells, resulting in a decrease in drug efficacy.

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