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Berberine hydrochloride sustained-release gel and preparation method thereof

A technology of berberine hydrochloride and slow-release gel, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of eczema that cannot achieve direct therapeutic effect and has poor application effect. Improve patient compliance, reduce cost, and reduce itching

Pending Publication Date: 2022-08-05
辽宁方诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the commercially available berberine hydrochloride is oral tablets, which cannot achieve direct therapeutic effect on eczema, and the application effect is not good.

Method used

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  • Berberine hydrochloride sustained-release gel and preparation method thereof
  • Berberine hydrochloride sustained-release gel and preparation method thereof
  • Berberine hydrochloride sustained-release gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The berberine hydrochloride sustained-release gel described in this example, its preparation raw materials include:

[0044] The following percentages are the percentages of each component in the total weight of the gel.

[0045] component Quality Score Berberine hydrochloride 0.2％ Carbomer 940 1.5％ glycerin 6.67％ Tween 80 2.33％ peppermint 0.3％ ethyl paraben 0.4％ water add to 15g

[0046] The preparation method of this embodiment comprises the following steps:

[0047] (1) Weigh the prescribed amount of Carbomer 940 and mix it in a 100mL beaker, add glycerol dropwise and stir to wet, add 9mL of water to stir, leave at room temperature for 4-6h, fully swell, and set aside.

[0048] (2) Weigh berberine hydrochloride into a small beaker, add 3 mL of 0.1 mol / L hydrochloric acid and 2 mL of 95% ethanol, heat to dissolve, and put it to room temperature for later use.

[0049] (3) adding (2) drug solution into (1), sti...

Embodiment 2

[0053] The berberine hydrochloride sustained-release gel described in this example, its preparation raw materials include:

[0054] component Quality Score Berberine hydrochloride 0.2％ Carbomer 940 1.5％ HPMC K4M 1％ glycerin 6.67％ Tween 80 2.33％ peppermint 0.3％ ethyl paraben 0.4％ water add to 15g

[0055] The preparation method of this embodiment comprises the following steps:

[0056] (1) Weigh and mix carbomer 940 and hydroxypropyl methylcellulose in the recipe amount in a 100mL beaker, add dropwise glycerin, stir and wet, add a certain amount of water, stir, leave at room temperature for 4-6h, fully swell, and set aside.

[0057] (2) Weigh berberine hydrochloride into a small beaker, add 3 mL of 0.1 mol / L hydrochloric acid and 2 mL of 95% ethanol, heat to dissolve, and put it at room temperature for later use.

[0058] (3) adding (2) drug solution into (1), stirring fully, adding Tween-80, peppermint oil, ethy...

Embodiment 3

[0062] The berberine hydrochloride sustained-release gel described in this example, its preparation raw materials include:

[0063] component Quality Score Berberine hydrochloride 0.2％ Carbomer 940 1.5％ HPMC K15M 1％ glycerin 6.67％ Tween 80 2.33％ peppermint 0.3％ ethyl paraben 0.4％ water add to 15g

[0064] The preparation method is the same as that of Example 2.

[0065] The in vitro release test method is the same as that in Example 1. In vitro release profile see figure 1 .

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to berberine hydrochloride sustained-release gel and a preparation method thereof. According to the invention, berberine hydrochloride is used as a model drug, carbomer 940 is used as a matrix, and hydroxypropyl methyl cellulose (HPMC) is used as a hydrophilic gel skeleton material, and is used as a retardant and a controlled release agent of hydrophilic sustained-release gel; and meanwhile, glycerol, ethanol, peppermint oil and the like are added to prepare the berberine hydrochloride sustained-release gel. The invention relates to a berberine hydrochloride shampoo, which is prepared from the following components in percentage by weight: 0.2 to 0.3 percent of berberine hydrochloride, 1 to 1.67 percent of carbomer 940, 0.67 to 1.67 percent of hydroxypropyl methyl cellulose, 6 to 13.3 percent of glycerol, 1.33 to 2.5 percent of tween-80, 0.3 to 2 percent of peppermint oil, 0 to 0.5 percent of preservative and the balance of water. The hydrophilic gel prepared by the invention has good biocompatibility, is easy to coat and use, has the characteristics of easy absorption, no pollution to clothes, good stability and the like after local administration, is used for treating eczema and dermatitis, and has a better application effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a berberine hydrochloride sustained-release gel and a preparation method thereof. Background technique [0002] Eczema is a general term for a special class of skin inflammatory diseases, and its clinical manifestations are characterized by symmetrical distribution, exudative, pruritic, polymorphic, and prone to recurrence and chronicity. Pediatric eczema, also known as eczematous dermatitis or atopic dermatitis, is a common skin disease closely related to allergy caused by a variety of internal and external factors. 1 to 3 months after birth, most of the children gradually healed after 1 and a half years old, and some children were extended to childhood. Infants and young children with eczema mostly occur on the cheeks, forehead, between the eyebrows and the head. In severe cases, the trunk and limbs can also appear. The repeated skin lesions, itching and se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K47/38A61K47/10A61K47/44A61K31/4375A61P17/00A61P17/04
CPCA61K9/06A61K9/0014A61K47/32A61K47/38A61K47/10A61K47/44A61K31/4375A61P17/00A61P17/04Y02A50/30
Inventor 李静赵祥宇李国杰
Owner 辽宁方诺生物科技有限公司
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