Method recovering butylacetate in antibiotic production process

A technology for butyl acetate and production process is applied in the field of recovering butyl acetate in the production process of antibiotics, and can solve the problems of low recovery yield of butyl acetate, increased difficulty in wastewater treatment, corrosion of distillation equipment, etc. The effect of improving the recovery rate and reducing the cost of recovery

Inactive Publication Date: 2005-11-16
NORTH CHINA PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The shortcoming of this method is: steam consumption is big, needs to carry out twice distillation; The recovery yield of butyl acetate is low, is generally 90-91%; Recovery cost is high; Wastewater forms many macromolecular polymers through high-temperature distillation, increases Reduced the difficulty of wastewater treatment; high-temperature wastewater corrodes the distillation equipment severely, and the service life of the equipment is short

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Application of the method of the present invention to reclaim butyl acetate in penicillin production wastewater

[0019] With the production waste water (butyl acetate content is 1%) produced in the penicillin extraction process, after adjusting pH4, flow through with BD-1 type diene cross-linked fatty acid ester macroporous copolymer resin from the top with 280 liters / hour flow velocity (Tianjin University Resin Factory) resin column, when the effluent at the bottom of the resin column was detected by acid-base titration to have butyl acetate flow out, the feed was stopped, and the effluent waste water entered the sewage treatment station. After the waste water in the column is emptied, wash the saturated resin with water, and then inject saturated steam from the bottom of the resin column for thermal desorption. The steam pressure is controlled below 0.05Mpa. Butyl ester and the incoming steam form an azeotrope and begin to overflow from the top of the resin column. A...

Embodiment 2

[0021] Application of the inventive method to reclaim butyl acetate in erythromycin production wastewater

[0022] With the production waste water (butyl acetate content being 0.5%) produced in the erythromycin extraction process, after adjusting pH4, flow through with S-1 type aliphatic hydrocarbon gel resin (Tianjin University resin) from the top with 350 liters / hour flow rate Factory) resin column, when the effluent at the bottom of the resin column is detected by acid-base titration to have butyl acetate flow out, the feeding is stopped, and the effluent waste water enters the sewage treatment station. After the waste water in the column is emptied, first wash the saturated resin with water, and then inject saturated steam from the bottom of the resin column for thermal analysis. The steam pressure is controlled below 0.05Mpa. The butyl ester and the incoming steam form co-products and begin to overflow from the top of the resin column. After being condensed by the condens...

Embodiment 3

[0024] Application of the method of the present invention to remove butyl acetate in the penicillin stripping solution

[0025] Concentration is the penicillin stripping solution of 0.5g / ml, and wherein butyl acetate content is 17%, flows through column top with BD-2 type cross-linked fatty acid ester macroporous copolymer resin (Tianjin) with the flow velocity of 100 liters / hour University Resin Factory) resin column, when the effluent at the bottom of the resin column was detected by acid-base titration to have butyl acetate flow out, the feed was stopped, and the effluent entered the penicillin extraction process. Empty the material liquid in the column, wash the saturated resin column with water until the penetration of penicillin reaches more than 99%, and then pass saturated steam from the bottom of the resin column for thermal analysis. The steam pressure is controlled below 0.05Mpa. When the temperature at the top of the column reaches 93 At ℃, the azeotrope formed by ...

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Abstract

A process for recovering the butyl acetate generated during production of antibiotics includes resin adsorption of the solution containing the butyl acetate, water washing, analyzing the saturated resin by saturated steam, condensing the analyzed liquid, laying asid, and phase separation. Its advantages are high recovery rate, less energy consumption and low cost.

Description

Technical field: [0001] The present invention relates to the reclaim of organic solvent, specifically a kind of method of reclaiming the butyl acetate in antibiotic production process. Background technique: [0002] Penicillin, erythromycin and many other antibiotics are produced by microbial fermentation, and their production process includes fermentation, filtration, extraction, stripping, crystallization and other steps. These antibiotics exist in different chemical states (free acid, alkali or salt state) under different pH conditions. They have different solubility in water and water-immiscible solvents. Using this property can make these antibiotics from a liquid The state is transferred to another liquid for the purpose of concentration and purification. Therefore, in the production process of antibiotics, butyl acetate is often used for extraction or stripping. Due to the existence of many degradation products, pigments, proteins and other impurities in the antibio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F1/28C07C67/56C07C69/14
CPCY02P20/50
Inventor 平志存刘庆芬杨志杰徐更王佳玉刘会洲
Owner NORTH CHINA PHARMA COMPANY
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