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Degradable composite support frame and its preparing process

A composite scaffold and manufacturing method technology, applied in the field of biomedical materials, can solve problems such as slow degradation rate, and achieve the effects of reducing the occurrence of aseptic inflammation and improving cell adhesion characteristics

Inactive Publication Date: 2006-02-22
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-sintered nano-hydroxyapatite is a low-crystallinity hydroxyapatite, and its ion concentration product in solution is about 14 to 16 orders of magnitude higher than that of ordinary sintered hydroxyapatite ceramics, so non-sintered nano-hydroxyapatite Stone can gradually dissolve after being implanted in the body, and its degradation mechanism in the body is mainly based on dissolution, but its degradation rate is slower than that of tricalcium phosphate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Grind 1 part (by mass, the same below) of nano-hydroxyapatite (average particle size 40-100nm, the same below) and 9 parts of β-tricalcium phosphate (particle size 1-10 μm) and mix evenly, The inorganic composite of nano-hydroxyapatite / β-tricalcium phosphate was obtained. Add the prepared inorganic compound to 450 parts of pre-prepared chloroform solution containing 20% ​​PDLLA (molecular weight 70,000), stir until uniform, then ultrasonically disperse for 2 minutes, then add 500 parts of ~150μm NaCl particles, after stirring, continue to sonicate for 1 minute, and then pour into shape.

[0022] Put the molded product in a fume hood, volatilize at 35°C for 30 hours, then remove the mold, and then put it in a vacuum desiccator to evacuate (100mmHg) for 24 hours. Fix the dried moldings in double distilled water for soaking, and replace the distilled water every 5 to 6 hours until no chlorine ions [Cl - ]. Take out the molded product, put it into a desiccator to dry for...

Embodiment 2

[0025] 1 part of nano-hydroxyapatite (40-100 nm) and 3 parts of β-tricalcium phosphate (1-10 μm) are ground together and mixed evenly to obtain an inorganic composite of nano-hydroxyapatite / β-tricalcium phosphate. Add it to 160 parts of tetrahydrofuran solution containing 10% L-lactic acid / glycolic acid copolymer (molecular weight: 350,000) prepared in advance, stir until uniform, then ultrasonically disperse for 2 minutes, then add 180 parts of For 120 μm NaCl particles, continue to sonicate for 1 minute after stirring, and then pour into shape.

[0026] The molded product was placed in a fume hood, volatilized at 34°C for 48 hours, then removed from the mold, and then placed in a vacuum desiccator to evacuate (100mmHg) for 24 hours. Fix the dried moldings in double distilled water for soaking, and replace the distilled water every 5 to 6 hours until no chlorine ions [Cl - ]. Take out the molded product, first place it in a desiccator to dry for 24 hours, and then vacuumize...

Embodiment 3

[0029] 1 part of nano-hydroxyapatite (40-100 nm) and 19 parts of β-tricalcium phosphate (1-10 μm) are ground together and mixed uniformly to obtain an inorganic composite of nano-hydroxyapatite / β-tricalcium phosphate. Add it to 80 parts of pre-prepared ethyl acetate solution containing 25% PCL (molecular weight: 110,000), stir until roughly uniform, then ultrasonically disperse for 2 minutes, then add 360 parts of NaCl particles with a particle size of 50-83 μm , continue to sonicate for 1 minute after stirring, and then pour into shape.

[0030]The molded product was placed in a fume hood, volatilized at 38° C. for 24 hours, and then demolded, and then placed in a vacuum desiccator to be evacuated (100 mmHg) for 24 hours. The dried moldings are fixed and soaked in double distilled water, and the distilled water is replaced every 5 to 6 hours until no chloride ion [Cl - ]. The molded product was taken out, placed in a desiccator to dry for 24 hours, and then vacuumed (100 mm...

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Abstract

The invention relates to an inorganic / organic degradable composite porous support material and its preparing process, wherein the mass percent content of each constituent in the materials are, degradable polymer 40-90%, beta-tricalcium phosphate 9.5-45%, nano hydroxyapatite 0.5-15%. The invention also provides the process for preparing the materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone tissue substitute material and its preparation. Background technique [0002] The use of tissue engineering technology to repair bone defects is a major advancement in the field of orthopedics and biomedical engineering. The degradable porous scaffold material is one of the three core elements in the realization of tissue engineering technology. It not only plays a structural supporting role in the body, but also It provides places and boundaries for cell adhesion, growth, reproduction, and tissue regeneration and shaping. As a bone tissue engineering scaffold material, it should have the following conditions: (1) Good biocompatibility and osseointegration ability; (2) ) Appropriate pore size and porosity; (3) A surface suitable for cell adhesion, growth and reproduction; (4) Degradable absorption, and the rate of degradation and absorption is controllable; ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04
Inventor 张胜民曹瑞锐骆清铭
Owner HUAZHONG UNIV OF SCI & TECH
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