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Monodispersity nano/micron polymer microsphere resin and method for preparing same

A polymer and monodisperse technology, applied in the field of preparation of nano/micro polymer microspheres, can solve the problems of limiting the application and effectiveness of microspheres

Inactive Publication Date: 2006-07-26
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Emulsion polymerization can synthesize submicron-sized monodisperse polymer particles, but the continuous deposition of anionic or nonionic surfactants on the polymer and entrapment in the polymer particles limits the effectiveness of the method
Dispersion polymerization and suspension polymerization can synthesize micron-sized monodisperse and broadly dispersed polymer particles, but stabilizers and dispersants are attached to the surface of microspheres, which limits the application of microspheres

Method used

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  • Monodispersity nano/micron polymer microsphere resin and method for preparing same
  • Monodispersity nano/micron polymer microsphere resin and method for preparing same
  • Monodispersity nano/micron polymer microsphere resin and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0030] Example 1: In a 500 ml two-necked flask with a fractionating column and a condenser, add divinylbenzene (10 ml, 9.2 g, 70.7 mmol), N, N'-azobisisobutyronitrile (AIBN) (0.184 g, 1.12 mmol, 2 wt % relative to the mass of the monomer) and 400 ml of acetonitrile. Heating the reaction system, making the reaction system rise from room temperature to boiling state in about 30 minutes, and reacting in the boiling state for 30 minutes. After half of the solvent in the reaction system was distilled off within 1.5 hours, the reaction ended. When the reaction system kept boiling for 15 minutes, it changed from a uniform and transparent state to a turbid milky white. Polymer microspheres were gradually formed during solvent evaporation and precipitated from the reaction system. After the reaction, the polymer microspheres were separated by filtration under reduced pressure, and then the polymer microspheres were washed three times with tetrahydrofuran (THF), acetone, and ether in ...

example 2

[0032] Example 2: In the system after the reaction of Example 1 was stopped, continue to add AIBN (0.184 grams, 1.12 mmol) initiator and 200 milliliters of acetonitrile. Heating the reaction system, making the reaction system rise from room temperature to boiling state in about 30 minutes, and reacting in the boiling state for 30 minutes. After half of the solvent in the reaction system was distilled off within 1.5 hours, the reaction ended. The polymer microspheres gradually grow further during the solvent evaporation process without secondary nucleation to form smaller polymer microspheres, and the polymer microspheres still maintain good monodispersity. Precipitated from the reaction system. After the reaction, the polymer microspheres were separated by filtration under reduced pressure, and then the polymer microspheres were washed three times with THF, acetone, and ether in sequence. The resulting polymer microspheres were dried in a vacuum oven to constant weight. The...

example 3

[0033]Example 3: In a 100 milliliter two-necked flask with a fractionating column and a condenser, add divinylbenzene (1.2 milliliters, 1.1 grams, 8.5 mmol), p-chloromethylene styrene (CMSt, 0.8 milliliters, 5.2 mmol), AIBN (0.04 g, 0.24 mmol, 2 wt % relative to the mass of monomer) and 80 ml of acetonitrile. Heating the reaction system, making the reaction system rise from room temperature to boiling state in about 30 minutes, and reacting in the boiling state for 20 minutes. After half of the solvent in the reaction system was distilled off within 1.5 hours, the reaction ended. When the reaction system kept boiling for 15 minutes, it changed from a uniform and transparent state to a turbid milky white. Polymer microspheres were gradually formed during solvent evaporation and precipitated from the reaction system. After the reaction, the polymer microspheres were separated by filtration under reduced pressure, and then the polymer microspheres were washed three times with T...

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Abstract

The invention relates to a monodispersed nm / mm polymer micro ball resin and its preparing method. The polymer micro ball is 20% cross linked gel polyene monomer copolymer or the copolymer micro ball of polyene monomer and other functional monoene monomer, whose diameter of particle is 100nm-10mm and the degree of dispersion is 1.017-1.037, the of transformation ratiocontent is al-3.0mnol / g; a series of monodispersed polymer micro ball with different particle size is made through stepped feeding material method. The invention the characteristics such as simple conditions easy operation, relatively low toxicity and friendly to the environment, with cheap raw material and high transformation ratio. The invention can be applied in filler of chromatographic column, carrier of catalyst, carrier of template synthesis, optic al arrange material and biological molecule, such as biological enzyme and antibody.

Description

technical field [0001] The invention relates to the preparation of nano / micro polymer microspheres, in particular to a monodisperse nano / micro polymer microsphere resin and a preparation method thereof. Background technique [0002] Polymer microspheres and microcapsules with internal structures are attractive for applications in many fields, such as supporting stationary phases in separation science, biological devices, injection molding additives, and carriers for controlled drug release, etc. The method of the reported synthetic polymer microsphere mainly contains: emulsion polymerization [Verruer-Charleux, B., Graillat, C., Chevalier, Y., Pichot, C., Revillon, A., Colloid Polym.Sci.1991, 269:398.], suspension polymerization [Balakrishnan, T., Lee, J., Ford, W.T., Macromol. Synth. 1990, 10, 19.], seed swelling polymerization [Liang, Y.C., Svec, F., Frechet, J.M.J., J.Polym.Sci., Part A: Polym.Chem.1997, 35:2631.], dispersion polymerization [Margel, S., Nov, E., Fisher, I...

Claims

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Application Information

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IPC IPC(8): C08F12/08C08F20/10C08F4/04C08F4/34C08F2/06
Inventor 黄文强白锋杨新林
Owner NANKAI UNIV
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