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Garlicin injection emulsion and its preparing method

An allicin and injection technology, applied in the field of medicine, can solve the problems of unfavorable clinical application and storage of allicin preparations, high body irritation, insufficient stability of allicin and the like

Inactive Publication Date: 2006-08-02
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The preparations involved in the above patent documents are generally irritating to the body and the stability of allicin is insufficient, which brings adverse effects on the clinical application and storage of allicin preparations

Method used

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  • Garlicin injection emulsion and its preparing method

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Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of allicin intravenous submicroemulsion injection, the prescription of this dosage form consists of:

[0033] Synthetic allicin (the content of allicin is 97.0~103.0%) 2g

[0034] Soy Lecithin for Injection 10g

[0035] Soybean oil for injection 16g

[0036] Glycerin for injection 3g

[0037] Add water for injection to 1000ml

[0038] The preparation method is:

[0039]1. Weigh the prescribed amount of allicin and add it to soybean oil for injection and mix well to form an oil phase;

[0040] 2. Weigh the soybean lecithin for injection, glycerin for injection and 100ml water for injection of the prescribed dosage, and stir to dissolve completely;

[0041] 3. Add the oil phase to the water phase under stirring, and then put it into an ultrasonic cell pulverizer to pulverize and stir to form colostrum;

[0042] 4. Transfer the colostrum into a high-pressure homogenizer and homogenize to obtain an emulsion with an average particle size o...

Embodiment 2

[0046] Embodiment 2: the preparation of allicin submicroemulsion injection, the prescription of this dosage form consists of:

[0047] Synthetic allicin (the content of allicin is 97.0~103.0%) 8g

[0048] Soy Lecithin for Injection 21g

[0049] Poloxamer 188 3.5g

[0050] Propylene glycol for injection 4g

[0051] Mannitol for injection 14.5g

[0052] Soybean oil for injection 100g

[0053] Add water for injection to 1000ml

[0054] The preparation method is:

[0055] 1. Weigh the prescribed amount of allicin and add it to soybean oil for injection and mix well to form an oil phase;

[0056] 2. Weigh soybean lecithin for injection, poloxamer 188, propylene glycol for injection, mannitol for injection, and 250ml of water for injection of the prescribed dosage, stir to dissolve completely, and make into water phase;

[0057] 3. Add the oil phase to the water phase under stirring, and then put it into an ultrasonic cell pulverizer to pulverize and stir to form colostrum; ...

Embodiment 3

[0062] Embodiment 3: the preparation of allicin submicroemulsion injection, the prescription of this dosage form consists of:

[0063] Allicin raw material medicine (the content of allicin is 81.0~87.0%) 12.5g

[0064] Soy Lecithin for Injection 15g

[0065] Tween 80 4g

[0066] Glycerin for injection 7g

[0067] Castor oil 100g

[0068] Sodium deoxycholate 2.5g

[0069] Add water for injection to 1000ml

[0070] The preparation method is:

[0071] 1. Weigh the prescribed amount of allicin and add it to castor oil for injection and mix well to form an oily phase;

[0072] 2. Weigh soybean lecithin for injection, Tween 80, glycerin for injection, sodium deoxycholate, and 500ml of water for injection of the prescription dose, stir to dissolve completely, and make into an aqueous phase;

[0073] 3. Add the oil phase to the water phase under stirring, and then put it into an ultrasonic cell pulverizer to pulverize and stir to form colostrum;

[0074] 4. Transfer the colost...

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Abstract

The garlicin emulsion injection is a kind of water base dispersion; has dispersed phase of average size smaller than 1 micron, and with garlicin in 0.5-2.5 weight portions, emulsifier for injection 0.2-7.5 weight portions, co-emulsifier 0-3 weight portions, oil phase dispersing medium 5-20 weight portions and isosmotic agent 0.5-3 weight portions; and contains garlicin in 1-20 mg / ml. The preparation process includes mixing garlicin, emulsifier, co-emulsifier, oil phase dispersing medium and isosmotic agent and adding water for injection; ultrasonic crushing to form initial emulsion and further emulsification in high pressure emulsifying machine to form water base dispersed phase of average size smaller than 1 micron; regulating pH to 5-7, microporous film filtering, packing and sterilizing to obtain garlicin injection. The present invention solves the problem of poor water solubility and less stimulation to blood vessel and raised garlicin stability.

Description

technical field [0001] The invention relates to an allicin injection emulsion and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Allicin is the main component of garlic volatile oil obtained from underground bulbs of Allium Satirum L., which is a plant of the genus Allium in the Liliaceae family, after crushing and steam distillation. The English name of allicin is Allitride, and its chemical name is trithiodipropylene. for C 6 h 10 S 3 , the molecular weight is 178.33, and the molecular structure formula is as follows: [0003] [0004] Allicin is mainly used for sterilization. It is known as a natural "broad-spectrum antibiotic" in nature. It has inhibitory and killing effects on a variety of bacteria and fungi. It can be used to treat dysentery and enteritis. In recent years, allicin has also been used clinically. used in the treatment of tumors. In addition, allicin also has the effects of improving the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/105A61K9/107A61P35/00A61P1/00A61P31/04A61P9/12A61P3/06A61P39/06A61P37/04
Inventor 杨祥良徐辉碧刘卫唐琛霞陈华兵周小顺
Owner HUAZHONG UNIV OF SCI & TECH
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