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Fluoro comzole coordination polymer, preparation method and use

A coordination polymer, fluconazole technology, applied in the direction of organic compound/hydride/coordination complex catalysts, copper organic compounds, chemical instruments and methods, etc., can solve the difficulties of catalyst recovery, poor selectivity of quinone, Solvents pollute the environment and other problems, and achieve potential economic benefits, good selectivity, and good selectivity

Inactive Publication Date: 2006-08-23
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve a series of problems such as poor selectivity, low yield, difficult catalyst recovery, and solvent pollution of the environment generated by the hydroxylation of phenol, the present invention provides a nitrogen-containing organic compound fluconazole and transition metal chloride The fluconazole coordination polymer prepared by the self-assembly reaction also provides a method for preparing the catalyst, and this polymer can be used as a catalyst for the hydroxylation of phenol hydrogen peroxide to prepare catechol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of fluconazole coordination polymer: the methanol solution of 15ml fluconazole (0.04mmol.ml -1 ) was added dropwise to 6mlFeCl 2 .4H 2 O methanol solution (0.05mmol.ml-1 ), stirred evenly, and stood at room temperature. After one month, yellow crystals were generated, namely, fluconazole iron coordination polymer, with a yield of 73%. Analyzed by X-single crystal diffractometer, it is a coordination polymer with a two-dimensional network structure, and its molecular formula is: (C 28 h 32 Cl 2 f 4 FeN 12 o 4 ) n .

[0033] Used as a catalyst: Add 0.5g of phenol into a container, add 15ml of water as a solvent, stir and add 10mg of fluconazole iron coordination polymer (as a catalyst), heat to 40°C under stirring, add H 2 o 2 (30%) 0.5ml to start timing, stop the reaction after 1 hour. The reaction product was detected by high performance liquid chromatography, and the results showed that the conversion rate of phenol was 62%, the content of catech...

Embodiment 2

[0035] 20ml methanol solution of fluconazole (0.04mmol.ml -1 ) was added dropwise to 8mlCdCl 2 .2.5H 2 In methanol solution of O (0.05mmol.ml -1 ), stirred evenly, and stood at room temperature. After 3 days, a colorless single crystal was generated, which was a cadmium coordination polymer of fluconazole, and the yield was 79%. Analyzed by X-single crystal diffractometer, it is a coordination polymer with two-dimensional network structure, and its molecular formula is: (C 28 h 32 Cl 2 f 4 CdN 12 o 4 ) n .

[0036] Add 0.5g of phenol into the container, add 15ml of water as a solvent, stir and add 10mg of fluconazole cadmium coordination polymer (as a catalyst), heat to 60°C under stirring, add H 2 o 2 (30%) 0.5ml starts timing, stops reaction after 1 hour, and phenol basically has no conversion.

Embodiment 3

[0038] 15ml of fluconazole methanol solution (0.02mmol.ml -1 ) was added dropwise to 3mlCuCl 2 2H 2 Aqueous solution of O (0.05mmol.ml -1 ), shake well, and stand at room temperature. After 3 days, a blue single crystal appears, and the copper coordination polymer of fluconazole is obtained, with a yield of 77%. Characterized by X-single crystal diffractometer analysis, it is a coordination polymer with a two-dimensional network structure, and the molecular formula is (C 28 h 32 Cl 2 f 4 CuN 12 o 4 ) n .

[0039] Add 0.5g of phenol into the container, add 15ml of water as a solvent, stir and add 15mg of fluconazole copper coordination polymer (as a catalyst), heat to 50°C under stirring, add H 2 o 2 (30%) 0.5ml to start timing, stop the reaction after 1 hour. After separation by filtration, the reaction product was detected by high-performance liquid chromatography. The results showed that the conversion rate of phenol was 78%, the content of catechol in the produc...

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Abstract

A fluorofurfurlazole cooling polymer used as the catalyst for preparing pyrocatechol by the hydroxylation reaction between phenol and H2O2 with high selectivity is prepared from fluorofurfurylazole and the chloride of transition metal through self assembling and culturing.

Description

Technical field: [0001] The invention relates to a coordination polymer produced by a nitrogen-containing ligand and a transition metal, a preparation method and an application thereof. Background technique: [0002] In recent years, the research of supramolecular chemistry has developed rapidly, and the construction of supramolecules by crystal engineering is one of the main goals of supramolecular chemistry research, especially the coordination polymers with topological structure, which have received unprecedented attention. Coordination polymers are formed through the self-assembly of transition metals and organic ligands under mild conditions. They combine the characteristics of composite polymers and coordination compounds, and have many forms such as chains, grids, trapezoids, and cages. Coordination polymers with this structure have been synthesized. Because of their structural diversity, they exhibit unique properties and have broad application prospects in nonlinear...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/16C07F1/08C07F15/00C07C39/08C07C37/60C08G83/00
Inventor 侯红卫韩华云樊耀亭孟祥茹牛云垠
Owner ZHENGZHOU UNIV
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