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Oslasodine hydrochloride preparing process

A technology of solanamine hydrochloride and Australian eggplant, applied in the field of preparation of Australian solanamine hydrochloride, can solve the problems of product quality, poor curative effect, complex and cumbersome process, poor production safety, etc., and achieve simple and convenient preparation process and equipment, The effect of high product purity and low cost

Inactive Publication Date: 2006-09-20
刘良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese invention patent 00129122.X "Australian solanamine hydrochloride and its production method and its application in medicine" provides a production method of Australian solanamine hydrochloride, but this method still has complex and cumbersome processes and production costs High, large investment in equipment, poor production safety, long production cycle, poor product quality and curative effect, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 prepares Australian solanamine hydrochloride with Solanum nigrum as raw material

[0029] With reference to accompanying drawing, prepare Australian solanamine hydrochloride with nightshade fruit, its preparation method is as follows:

[0030] (1) Weigh 500kg of unripe nightshade fruits harvested from mid-October to late October to remove impurities, pulverize solid-liquid separation with a refiner to obtain fruit juice and pomace, and soak the nightshade pomace with 3% acetic acid aqueous solution 2 times, the weight ratio of solid to liquid is 1:1, the solid and liquid are separated to obtain the infusion, the fruit juice and the infusion are combined, and the supernatant I is obtained by standing and settling. Take the supernatant I and heat it to boiling, remove the floating green colloid, filter and cool, and place the filtrate to settle to obtain the supernatant II. Take the supernatant II and heat it to 85°C, add concentrated ammonia water to pH 8, ...

Embodiment 2

[0034] Example 2 Prepare Australian solanamine hydrochloride with yellow fruit eggplant as raw material

[0035] With reference to accompanying drawing, prepare Australian solanamine hydrochloride with yellow fruit eggplant fruit, its preparation method is as follows:

[0036] (1) Get 500kg of yellow fruit eggplant fruit, after crushing, solid-liquid separation is obtained to obtain fruit juice and pomace, and the pomace is leached twice with 3% acetic acid, with a solid-liquid weight ratio of 1: 1, and each leaching for 30 minutes, solid-liquid Separate the infusion, combine the fruit juice and the infusion, place and settle to obtain the supernatant I. Take the supernatant I and heat it to boiling, remove the floating green impurities, filter and cool, place and settle to get the supernatant II. Take the supernatant II and heat it to 80°C, add NaOH solution to PH8, cool and settle to remove the supernatant, and centrifuge the turbid liquid to separate the solid and liquid t...

experiment example 3

[0039] Experimental Example 3 Prepare Australian solanamine hydrochloride with Australian solanum as raw material

[0040] With reference to accompanying drawing, prepare Australian solanamine hydrochloride with Australian solanum fruit, its preparation method is as follows:

[0041] (1) Get 500kg Australian solanum fruit, and obtain supernatant II by the preparation method in Example 1 (1). The supernatant II flows through the styrene sulfonic acid type cation exchange resin column, and the flow rate is controlled until the effluent does not contain alkaloids. When the resin exchange alkaloid reaches saturation, the effluent begins to appear reddish purple with the SbCl2 ethanol solution Before the reaction, stop adding liquid, wash the resin column with distilled water to remove impurities until the effluent is colorless and transparent, take out the resin, dry it below 50°C, moisten it with concentrated ammonia water, put it into the column, and elute with 95% ethanol , co...

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Abstract

The invention provides an Oslasodine hydrochloride preparing process for anti-cancer, asthma relieving, anti-inflammation and increasing immunity. The preparation process comprises using Solanum Nigrum L, Solanum aviculare parst and Solanum xanthocar pum Schrad, et wendl fruit or herbs as raw material, employing unique acid leaching alkali precipitation extraction method, alkaline alcohol dissolving acidic alcohol crystallization for Oslasodine hydrochloride extraction.

Description

technical field [0001] The invention relates to a preparation method of a new drug source, australinamine hydrochloride, which is used to manufacture a class of new medicines of traditional Chinese medicines for anticancer, antiasthma, anti-inflammation and immunity enhancement. Background technique [0002] At home and abroad, there are chemical components of Solanum solanum, Solanum solanum and Solanaceae chrysanthemum, detection methods of solanamine and anti-S 180 , anti-inflammatory, and blood sugar-increasing effects. Chinese invention patent 00129122.X "Australian solanamine hydrochloride and its production method and its application in medicine" provides a production method of Australian solanamine hydrochloride, but this method still has complex and cumbersome processes and production costs High, large investment in equipment, poor production safety, long production cycle, poor product quality and curative effect. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00A61P35/00A61P11/06A61P29/00A61P37/04
Inventor 刘良刘芯辰崔淑华
Owner 刘良
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