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Total diterpene phenol originated from rosemary, its preparation method and use

A technology of total diterpene phenols and rosemary, applied in the field of total diterpene phenols derived from rosemary and its preparation and application, to achieve the effects of simple extraction method, reduction of oxidation, and environmental protection

Active Publication Date: 2007-01-31
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Previous studies mostly focused on the application of rosemary to antioxidants, and the use of effective parts of rosemary in the preparation of drugs for the prevention and treatment of cardiovascular and cancer has not been reported

Method used

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  • Total diterpene phenol originated from rosemary, its preparation method and use
  • Total diterpene phenol originated from rosemary, its preparation method and use
  • Total diterpene phenol originated from rosemary, its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1. Preparation of rosemary total diterpene phenols

[0024] The harvested rosemary is sun-dried and cut into sections. Add 10 times the amount of crude drug and 70% (v / v) ethanol for reflux extraction for 3 times; cool the combined extracts to 40°C, and filter to remove insolubles , To obtain a greenish-brown filtrate; decolorization: add 0.1% (g / ml) activated carbon of the filtrate volume weight percentage to this filtrate, decolorize at 55°C for 20 minutes, filter and remove the activated carbon to obtain a clear and transparent red-brown liquid medicine; The filtrate was concentrated to a drug solution with a relative density of 1.10, added 2 times the crude drug amount of water, stirred, filtered, and the water-soluble impurities were dissolved in the filtrate to be removed. The filter residue was dried and crushed to obtain the rosemary total diterpene of the present invention Phenol is a light yellow powder with a total phenol content of 80%. Such as figure 2 ...

Embodiment 2

[0025] Example 2. Preparation of rosemary total diterpene phenols

[0026] The harvested rosemary herbs were sun-dried and cut into sections, and 5 times the amount of crude drug was added to 90% (v / v) methanol percolation to extract once; the combined extracts were allowed to cool to 60°C and filtered to remove insoluble To obtain a green-brown filtrate; decolorization: add 0.05% (g / ml) activated carbon of the filtrate volume weight percentage to this filtrate, decolor at 30°C for 40 minutes, filter and remove the activated carbon to obtain a clear and transparent red-brown liquid medicine; Concentrate the filtrate to a drug solution with a relative density of 1.00, add 0.4 times the crude drug amount of water, stir, filter, and dissolve the water-soluble impurities in the filtrate to be removed. The filter residue is dried and pulverized to obtain a light yellow powder, which is the product of the present invention. The total diterpene phenols of rosemary are light yellow powder...

Embodiment 3

[0027] Example 3. Preparation of rosemary total diterpene phenols

[0028] The harvested rosemary medicinal materials were dried and cut into sections, added with 12 times the amount of the crude drug, 50% (v / v) acetone soaked and extracted 5 times; the combined extracts were allowed to cool to 20°C, and the insoluble matter was removed by filtration , To obtain a greenish-brown filtrate; decolorization: add 0.5% (g / ml) activated carbon of the filtrate volume weight percentage to this filtrate, decolorize at 80°C for 5 min, filter and remove the activated carbon to obtain a clear and transparent red-brown liquid medicine; The filtrate is concentrated to a drug solution with a relative density of 1.05, 4 times the crude drug amount of water is added, stirred, filtered, and the water-soluble impurities are dissolved in the filtrate to be removed. The filter residue is dried and pulverized to obtain a light yellow powder, which is the mystery of the present invention. The total diter...

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PUM

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Abstract

The invention relates to the effective parts of rosemary, its preparation method and use, wherein the effective parts of the Rosmarinus officinalisl are diterpenoids phenols extracted from medicinal material of Rosmarinus officinalisl, the content of the phenols is over 45%, and the sum of the content of the carnosol and carnosic acid as the principal ingredients is over 13%. The preparing process comprises curing the Rosmarinus officinalisl medicinal material and cutting it into chunks, charging raffinate for extraction, cooling down the merged extract and filtrating, decolorizing with activated charcoal, concentrating the filtrate and charging in water, filtering, drying and disintegrating the filtering deposit. The effective parts of the Rosmarinus officinalisl can be used for preparing medicament for preventing and treating cardiovascular diseases, epigastric pain, uterocarcinoma, cervical carcinoma, intestinal cancer and breast cancer.

Description

Technical field [0001] The invention relates to an effective part derived from Chinese medicinal materials and its preparation method and application, in particular to a total diterpene phenol derived from rosemary medicinal materials and a preparation method thereof, and its use in the preparation of prevention and treatment of heart disease Blood vessels, relieve chest pain and heartache, and treat uterine cancer, cervical cancer, intestinal cancer, breast cancer and other medicines. Background technique [0002] Rosemary (Rosmarinas officinalis L.) is a whole plant of the rosemary genus of the Labiatae family. It is a small evergreen shrub native to the Mediterranean region and is widely cultivated. It is mainly produced in Spain, Morocco, the former Yugoslavia, Southern European countries such as Bulgaria and Tunisia. In recent years, some provinces and regions in southwest my country (Guizhou, Yunnan) also have a large number of cultivation. The main part of rosemary is the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K35/68A61P9/00A61P9/10A61P35/00C07C39/23C07C37/72
Inventor 屠鹏飞齐学兵逄剑李志新
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE