Medicine for treating cardiovascular disease, and its prepn. method
A cardiovascular and drug technology, applied in the field of drugs for the treatment of cardiovascular diseases and their preparation, can solve the problems that the drug powder cannot penetrate the cell membrane rapidly, the drug effect cannot be fully exerted, and the compatibility is not good, and the myocardial oxygen consumption can be reduced. and oxygen consumption index, improving myocardial ischemia degree and improving bioavailability
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Embodiment 1
[0043] Pills
[0044] Take the following raw materials (in grams): Ginseng 670, Salvia miltiorrhiza 500, Rhizoma Chuanxiong 330, Epimedium 330, Corydalis 170, Borneol 67, Artificial Calculus Bezoar 130, Artificial Musk 100, appropriate amount of PEG-6000, dripping into 1000 drop pills, Each capsule weighs 30mg.
[0045] Preparation method: Take ginseng and soften the slices with 60% ethanol (V / V%) and reflux five times, combine the reflux liquid, refrigerate and filter, recover the ethanol from the filtrate, concentrate to a thick paste, add anhydrous calcium sulfate, mix well, and vacuum dry at 60°C , and then refluxed three times with ethanol, combined the reflux, refrigerated at 0°C and filtered, recovered ethanol from the filtrate, concentrated to a thick paste and dried under reduced pressure. Take Salvia miltiorrhiza and reflux with ethanol, filter the alcohol liquid, refrigerate at 0°C and filter, recover ethanol from the filtrate, concentrate to a thick paste and dry ...
Embodiment 2
[0049] Pills
[0050] Take the following raw materials (grams): ginseng 550, salvia miltiorrhiza 400, chuanxiong 230, epimedium 230, corydalis 100, borneol 30, artificial bezoar 90, artificial musk 60, appropriate amount of PEG-6000, and make 1000 drop pills. Weighs 30mg.
[0051] Preparation:
[0052] Weigh the prescription amount of ginseng, slice it (about 1mm in thickness) after softening with 50% ethanol. Reflux with 50% ethanol (V / V%) as follows: 1:6 (g / ml) for 2 hours once; 1:5 (g / ml) for 1.5 hours; 1:4 (g / ml) for 1 hour. Combine the above reflux liquids, let stand at 5°C for 24 hours, and filter. The clear alcoholic liquid recovered ethanol until exhausted, concentrated to a thick paste, and dried under reduced pressure at 50°C. The dry paste is weighed and kept airtight.
[0053] Weigh the prescribed amount of Salvia miltiorrhiza, soak it overnight with 6 times the volume of ethanol, filter out the alcohol solution after reflux for 2 hours, let stand at 5°C for 2...
Embodiment 3
[0066] Pills
[0067] Take the following raw materials (grams): ginseng 800, salvia miltiorrhiza 600, chuanxiong 430, epimedium 430, corydalis 240, borneol 100, artificial bezoar 170, artificial musk 140, appropriate amount of PEG-6000, and drop them into 1000g drop pills. 30 mg.
[0068] Preparation method: with embodiment 1. The difference is that the ginseng is softly sliced with 70% ethanol (V / V%) and refluxed 6 times, the reflux liquid is combined and refrigerated and filtered, the filtrate is recovered with ethanol, concentrated to a thick paste and mixed with anhydrous calcium sulfate, Vacuum dry at 70°C, then reflux with ethanol for 4 times, combine the reflux liquid, refrigerate and filter, recover ethanol from the filtrate, concentrate to a thick paste and dry under reduced pressure;
[0069] Said salvia miltiorrhiza was refluxed and concentrated to a thick paste and dried under reduced pressure; the medicinal dregs were decocted with water for 3 times, and the d...
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