Prepn of aminoglucose sulfate

Abstract

The method for preparing aminoglucose sulfate includes the following steps: using sulfuric acid whose mass concentration is 20-80% as hydralytic reagent, under the reaction condition of 80-150 deg.C hydrolyzing chitin, decolouring hydrolysate, extracting with organic solvent, recrystallizing or using alkali to make precipitation and separation to obtain the refined aminoglucose sulfate containingno chlorine ion. Its method is simple and yield rate is high.

Description

technical field

[0001] The invention relates to a method for preparing glucosamine sulfate. Background technique

[0002] Arthritis has been reported to be the number one disabling disease in the world. At present, there are as many as 355 million arthritis patients in the world. In Asia, 1 out of 6 people suffer from arthritis. In my country, there are more than 100 million arthritis patients, and the number is still increasing. With exacerbated joint pain and restricted mobility, temporary or permanent incapacity can result, with significant social and economic costs.

[0003] Glucosamine sulfate is a specific drug for arthritis. Studies on pharmacological action and mechanism of action show that glucosamine sulfate is a natural amino monosaccharide, which is an important component necessary for the synthesis of proteoglycans in the human articular cartilage matrix. The application of glucosamine sulfate to bone and joint patients can supplement the substances synthesiz...

Examples

Embodiment 1

[0016] Take 100 grams of chitin, add 350 grams of sulfuric acid with a mass concentration of 80%, control the reaction temperature at 80-150°C, and the reaction time is 8 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 5 times the volume of 95% ethanol solution to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 30.5%.

Embodiment 2

[0018] Take 100 grams of chitin, add 400 grams of sulfuric acid with a mass concentration of 70%, control the reaction temperature at 80-150° C., and the reaction time for 15 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 6 times the volume of isoamyl alcohol to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 35%.

Embodiment 3

[0020] Take 100 grams of chitin, add 1200 grams of sulfuric acid with a mass concentration of 20%, control the reaction temperature at 80-150° C., and the reaction time for 30 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 6 times the volume of isoamyl alcohol to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 42%.

technical field

[0001] The invention relates to a method for preparing glucosamine sulfate. Background technique

[0002] Arthritis has been reported to be the number one disabling disease in the world. At present, there are as many as 355 million arthritis patients in the world. In Asia, 1 out of 6 people suffer from arthritis. In my country, there are more than 100 million arthritis patients, and the number is still increasing. With exacerbated joint pain and restricted mobility, temporary or permanent incapacity can result, with significant social and economic costs.

[0003] Glucosamine sulfate is a specific drug for arthritis. Studies on pharmacological action and mechanism of action show that glucosamine sulfate is a natural amino monosaccharide, which is an important component necessary for the synthesis of proteoglycans in the human articular cartilage matrix. The application of glucosamine sulfate to bone and joint patients can supplement the substances synthesiz...

Examples

Embodiment 1

[0016] Take 100 grams of chitin, add 350 grams of sulfuric acid with a mass concentration of 80%, control the reaction temperature at 80-150°C, and the reaction time is 8 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 5 times the volume of 95% ethanol solution to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 30.5%.

Embodiment 2

[0018] Take 100 grams of chitin, add 400 grams of sulfuric acid with a mass concentration of 70%, control the reaction temperature at 80-150° C., and the reaction time for 15 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 6 times the volume of isoamyl alcohol to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 35%.

Embodiment 3

[0020] Take 100 grams of chitin, add 1200 grams of sulfuric acid with a mass concentration of 20%, control the reaction temperature at 80-150° C., and the reaction time for 30 hours. After the hydrolysis is completed, the hydrolyzed solution is decolorized with activated carbon. Add 6 times the volume of isoamyl alcohol to the supernatant for extraction. The separated hydrolyzate was recrystallized, washed with absolute ethanol, and dried in vacuum to obtain glucosamine sulfate. The yield was 42%.