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Blood plasma replacement composition

A technology of plasma substitutes and compositions, which is applied in the field of medicine and can solve the problems of not being able to stimulate the hematopoietic system and restore the function of the immune system at the same time.

Inactive Publication Date: 2002-11-13
亚历山大·V·阿萨福夫 +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0013] However, none of the plasma substitute compositions of the prior art, including multifunctional plasma substitutes, can simultaneously provide the effect of stimulating the hematopoietic system and restoring the function of the immune system

Method used

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Examples

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Embodiment Construction

[0023] embodiment of the invention

[0024] The compositions of the present invention are prepared under factory conditions by conventional volume-gravimetric methods.

[0025] According to the present invention, an appropriate amount of physiologically acceptable average molecular weight is (1.5-550) × 10 3 D, the hyperchromic effect is (28-47)% powdered DNA derivative salt, such as sodium salt, is dissolved in the solution of appropriate volume, makes its concentration greater than 0.5%, wherein said powder contains no more than 1.5% protein, no more than 2% polysaccharide, no more than 6% RNA, and the percentages are all percentages by weight. The solvent used therein is distilled water or physiological solution. Then the obtained solution is filtered and sterilized, and an appropriate amount of plasma substitute is added thereinto until reaching a suitable concentration, which can make the solution have an isotonic volume.

[0026] The results of the research show that ...

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PUM

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Abstract

The present invention relates to a medicament, in particular to a pharmaceutical preparation for the treatment of severe acute and chronic injuries in the human body which lead to hypovolemia and changes in blood function properties marked by immunodeficiency . The invention provides a plasma substitute composition with immune regulating effect. The present invention provides an application of a specific biologically active component, wherein the biologically active component is a physiologically available sodium salt of a DNA derivative, preferably a sodium salt prepared from animal raw materials such as sturgeon or salmon semen. The above composition is used for adjuvant therapy of activating hematopoietic cell generation and bone marrow cell generation without any side effect or complication.

Description

technical field [0001] The present invention relates to a medicament, especially a pharmaceutical preparation for treating severe acute and chronic injuries of the human body, which can lead to massive blood loss and changes in blood function properties. More particularly, the present invention relates to plasma substitute compositions. Background technique [0002] As we all know, severe acute injury and chronic injury are usually associated with hematopoietic system dysfunction and immune function deficiency, wherein said severe acute injury such as large area deep burn, sepsis caused by tissue necrosis caused by severe injury, frostbite, infiltration Severe chronic injuries such as various anemias, leukopenia, thrombocytopenia caused by chemotherapy associated with a certain cancer in the patient or by radiation effects or toxic effects in radiation or ecological accidents . [0003] Long-term immunodeficiency is also found in patients with acute and chronic infectious ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/711A61K35/14A61K35/16A61K35/60A61K39/00A61P7/08C12N15/11
CPCA61K9/0026A61K31/711A61K35/16A61K2039/55561A61P7/08C12N15/11
Inventor 亚历山大·V·阿萨福夫塔蒂亚纳·D·阿萨福夫
Owner 亚历山大·V·阿萨福夫
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