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Slow-releasing acipimox capsule

A technology of sustained-release capsules and acyclolimus, which is applied in the field of medicine, can solve the problems of aggravation of diabetes and gout patients, affecting the metabolic pathways of glucose and uric acid, poor safety, etc., and achieves convenient administration, extensive social and economic benefits, The effect of reducing side effects

Inactive Publication Date: 2003-02-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safety of clinical use is relatively poor. In addition to nausea, abdominal pain, flushing, and skin itching, it can also affect the metabolic pathways of glucose and uric acid, aggravating the condition of patients with diabetes and gout.

Method used

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  • Slow-releasing acipimox capsule
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  • Slow-releasing acipimox capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] (1) Preparation of pill core

[0027] Acipimus 190g

[0028] Blank ball core 300g

[0029] 7% PVP solution (solvent is 90% ethanol) 200g Preparation process:

[0030] Pass acipimox through a 160-mesh sieve, weigh the prescribed amount, and pour it into the lower hopper. Turn on the granulation coating machine, the air inlet pressure is 0.5bar, the CYL is 3bar, and the CAP1 is 0.8bar, pour blank ball cores, and granulate. The feeding speed is 4 rpm, the peristaltic pump is 12%, the rotation speed of the turntable is 145 rpm, spray 7% PVP solution (the solvent is 90% ethanol), and dry at 50°C. After the granulation is finished, 500g of the material is discharged.

[0031] (2) The eight specific prescriptions are as follows: (determine the type and quantity of the sustained-release agent) Prescription A:

[0032] With pill core 500g

[0033] Ethylcellulose 5g

[0034] Stearic acid 30g

[0035] Polyethylene glycol-6000 1g

...

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Abstract

A slow-releasing acipimox capsule for regualting blood fat is prepared from acipimox, empty core, slow-releasing agent, plasticizer and antisticking agent through preparing medicine core, drying, then coating slow-releasing layer, drying by blowing and loading in capsule. Its advantages are stable concentration of medicine in blood, durable acting and low toxic by-effect.

Description

Technical field [0001] The invention belongs to the medical technology, in particular to an acipimox sustained-release capsule, which is a high-efficiency and safe blood lipid regulating drug. Background technique [0002] In recent years, with changes in eating habits, improvements in living standards, and increased work pressure, there are more and more patients with hyperlipidemia and hyperproteinemia, and the patient population is getting younger and younger. Hyperlipidemia and hyperproteinemia are a group of common clinical disorders of lipid metabolism. When the concentration of plasma lipid exceeds the upper limit of normal value, it is called hyperlipidemia (Hyperlipemia), and the lipoprotein in plasma exceeds the normal value. The high limit is called hyperlipoproteinemia (Hyperlipoproteinemia). Epidemiological studies have shown that increased levels of plasma low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) are important factors for premature...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4965A61P3/06
Inventor 孙勇
Owner LUNAN PHARMA GROUP CORPORATION
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