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Nano Chinese medicine threewingnut/Tripterygium prepn and its prepn process

A technology of nano-Chinese medicine and Tripterygium wilfordii, which is applied in the direction of nano-structure manufacturing, nano-technology, and pharmaceutical formulations, and can solve problems such as high toxicity

Inactive Publication Date: 2003-02-26
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, these dosage forms still have a relatively large problem of toxicity

Method used

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  • Nano Chinese medicine threewingnut/Tripterygium prepn and its prepn process
  • Nano Chinese medicine threewingnut/Tripterygium prepn and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: 1. Preparation of blank solid lipid nanoparticles:

[0065] Take 200mg of stearic acid and 100mg of soybean lecithin, dissolve in 10ml of cyclohexane to form an organic phase; take another 0.75g of polyethylene glycol monostearate, stir and dissolve in 35ml of water to form an aqueous phase. The aqueous phase was heated to 70°C. While stirring rapidly, inject the organic phase into the water phase with a No. 6 needle, and continue stirring to completely evaporate the organic solvent and concentrate the system to 15 ml. Add 35ml of distilled water at 0-2°C, then sonicate for 10min, and dilute to 50ml to obtain a light blue transparent colloidal solution. The average particle size is 106 nm, and the polydispersity index is 0.228.

[0066] The preparation of blank solid lipid nanoparticles is mainly to provide reference samples for subsequent drug efficacy experiments and toxicity experiments. 2. Preparation of tripterygium wilfordii solid liposome nanopar...

Embodiment 2

[0072] Take Tripterygium wilfordii extract 200mg, soybean lecithin 100mg, dissolve in 5ml of ethanol, take another 200mg of triolein, dissolve in 5ml of cyclohexane, mix and stir evenly. Remove the organic solvent by rotary evaporation under reduced pressure in a constant temperature water bath at 45°C, so that the drug and excipients form a uniform lipid film on the wall of the flask, and then place it in a vacuum desiccator overnight to remove the organic solvent; another polyoxyethylene / polyoxyethylene 750 mg of propylene copolymer was stirred and dissolved in 35 ml of water, added to the above film, then ultrasonically treated for 15 min, and the volume was adjusted to 50 ml to obtain a dark yellow transparent colloidal solution.

Embodiment 3

[0074] Take tripterygium wilfordii extract 200mg, soybean lecithin 100mg, dissolve in 5ml of ethanol, take another 250mg of glycerol monooleate, dissolve in 5ml of cyclohexane, mix and stir evenly. Remove the organic solvent by rotary evaporation under reduced pressure in a constant temperature water bath at 45°C, so that the drug and excipients form a uniform lipid film on the wall of the flask, and then place it in a vacuum desiccator overnight to remove the organic solvent; another polyoxyethylene / polyoxyethylene 800mg of propylene copolymer was stirred and dissolved in 35ml of water, added to the above film, then ultrasonically treated for 15min, and the volume was adjusted to 50ml to obtain a dark yellow transparent colloidal solution.

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Abstract

The new nano Chinese medicine threwingnut / Tripteerygium preparation consists of threwingnut / Tripterrygium extraction, general lactone or general alkaloid 0.1-0.6 wt%, carrier 0.1-0.8 wt%, surfactant 0.8-3.8 wt% and water. The preparation process includes dissolving threwingnut / Tripteerygium extraction, general lactone or general alkaloid in alcohol, dissolving carrier in cyclohexane, mixing through stirring, depression rotary evaporation to eliminate organic solvent and to form medicine film onto the wall of flask, vacuum drying to eliminate organic solventm, dissolving surfactant in water and adding it to the film, and final supersonic treatment to obtain yellow transparent colloid solution.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a new dosage form of the nanometer traditional Chinese medicine Tripterygium wilfordii / Kunming mountain crabapple, that is, a traditional Chinese medicine Tripterygium wilfordii / Kunming mountain crabapple preparation prepared by nanotechnology. Background technique [0002] Both Tripterygium wilfordii and Kunming Shanhaitang belong to the genus Tripterygium genus in the family Euonymus. Both have the same traditional Chinese medicine function and can be substitutes for each other. Take Tripterygium wilfordii as example below to illustrate the present invention. [0003] The roots, leaves, flowers and fruits of Tripterygium wilfordii Hook..F are used as medicine. They taste bitter and are very poisonous. Recent studies have shown that Tripterygium wilfordii has pharmacological activities such as anti-tumor, anti-inflammatory and immun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K45/06
CPCA61K45/06A61K36/37A61K9/107
Inventor 杨亚江杨祥良徐辉碧梅之南殷以华韩定献刘琼
Owner HUAZHONG UNIV OF SCI & TECH
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