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Recombinant human granulocyte-macrophage colony stimulating factor gel

A technology of colony-stimulating factor and macrophages, which can be applied in drug combinations, peptide/protein components, skin diseases, etc., can solve the problems of inconvenient use, and achieve convenient portability and use, stable and controllable quality, and clear mechanism of action Effect

Inactive Publication Date: 2003-08-13
HARBIN PHARMA GROUP TECH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is aimed at the inconvenient technical problems and deficiencies in the use of freeze-dried dosage-type medical external-use biological products, and researches and develops a recombinant human granulocyte-macrophage colony-stimulating factor gel of non-freeze-dried dosage form and semi-solid preparation , to achieve the purpose of convenient use, lower cost, and guaranteed therapeutic effect

Method used

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Examples

Experimental program
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Embodiment Construction

[0006] Examples are given below. Select 350 grams of glycerol, 15 grams of carbomer, 10 grams of Benzene, 5 grams of sodium hydroxide, 10 grams of human serum albumin, and 10 grams of stock solution. 6 International units, the rest use purified water, a total of 1000 grams, the weight ratio of each component is: glycerol 35%, carbomer 1.5%, benzze 1%, sodium hydroxide 0.5%, human serum albumin 1%, Purified water was added to 100%. Among the formula ingredients, glycerin is used as a matrix, stabilizer, and protective agent; carbomer is a drug carrier; Benzene is a transdermal absorption accelerator; sodium hydroxide is used as a neutralizer to form the gel and adjust the pH of the gel (PH) to keep the stock solution biologically active; human serum albumin acts as a stabilizer and protective agent. The biological product is manufactured under normal temperature conditions, and the product process is as follows: 15 grams of carbomer is placed in an emulsification tank, 350 gr...

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Abstract

A gel of recombinant human granulocyte-macrophage colony stimulating factor for treating ulcer, scald, burn, mucitis and mucosa wound is prepared from carbomer, propanetriol, sodium hydroxide, raw liquid, human plasma albumin, purified water, etc. Its advantages are high curative effect and low dosage.

Description

technical field [0001] The invention relates to a medicinal biological product, which is a biotechnological medicine for external use to treat skin and mucous membrane wound diseases such as ulcers, scalds and burns. Background technique [0002] Recombinant human granulocyte-macrophage colony-stimulating factor is a product of modern biotechnology, which is an endogenous biologically active substance in the human body. The GM-CSF stock solution is stored at room temperature, and its activity will gradually decrease with time. In order to prolong the biological activity of the stock solution as far as possible, the current medicinal recombinant human epidermal growth factor (rhEGF) freeze-dried external preparations and external recombinant human basic fibroblast growth factor (rhbFGF) are all made into freeze-dried dosage forms to achieve the purpose of prolonging the biological activity of the stock solution. The purpose of biological activity is to prolong the validity p...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K38/19A61K38/22A61P17/02
Inventor 王忠
Owner HARBIN PHARMA GROUP TECH CENT
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