Method for induding andrographolide by cyclodextrin and medicinal preparation
A technology of andrographolide and cyclodextrin, which is applied in the inclusion process of andrographolide, and the field of cyclodextrin inclusion andrographolide, which can solve the problem of reducing the drug activity of andrographolide, low bioavailability of active ingredients, Improve drug toxicity and side effects, etc., to achieve the effect of ensuring pharmacological activity, small hemolysis, and good water solubility
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Embodiment 1
[0015] Preparation of andrographolide for injection
[0016] Proportion: 1. HP-β-CYD................................................ 2000g 2. Andrographolide ................................. 400g 3. Medicinal ethanol .............................................. 100ml 4. For injection Distilled water...................................2000ml 5. Low molecular weight dextran..... ..............................200 g
[0017] Prepare an ethanol solution with a concentration of 40-60% with distilled water for injection, add andrographolide into the alcohol solution, heat to 60-75°C to dissolve it; dissolve HP-β-CYD cyclodextrin with distilled water for injection and add Put it into the andrographolide alcohol solution, move it to an ultrasonic generator and vibrate ultrasonically for 30-45 minutes, control the temperature below 45°C, and identify the inclusion end point by thin-layer chromatography.
[0018] Prepare a low-molecular dextran solution, pour it into the andrograph...
Embodiment 2
[0020] Preparation of small-volume andrographolide injection 1, BE-β-CYD or HP-β-CYD........................... 12000 g 2, lindenolactone...................................4000 g 3. Medicinal ethanol ................................. 300ml 4. Injection With distilled water ................................. 5000ml
[0021] Prepare an ethanol solution with a concentration of 40-60% with distilled water for injection, add andrographolide into the alcohol solution, heat to 60-75°C to dissolve it: dissolve SEB-β-CYD cyclodextrin with distilled water for injection and add Put it into the andrographolide alcohol solution, move it to an ultrasonic generator and vibrate ultrasonically for 30-45 minutes, control the temperature below 45°C, and identify the inclusion end point by thin-layer chromatography.
[0022] Calculated on the basis of 10,000 vials, each 100ml (containing 400mg andrographolide) filling volume, make up distilled water for injection to 10,000,000ml, use 0.2μm micro...
Embodiment 3
[0024] Preparation of andrographolide oral agent 1, HP-β-CYD (or SBE-β-CYD) .......... 500 Gram 2, andrographolide ............................................. 100 g 3 , medicinal ethanol .................................................. 50ml4 , distilled water...................................2000ml5 , starch .............................................. 150 ~300g 6. Powdered sugar................................... ....50g 7. Edible essence................................... ...50 grams
[0025] Prepare an ethanol solution with a concentration of 4-60% with distilled water, add andrographolide into the alcohol solution, and heat to 60-75° C. to dissolve it. Prepare HP-β-CYD cyclodextrin solution (concentration: 600-700g / L), add it to andrographolide alcohol solution, move it to an ultrasonic generator for ultrasonic oscillation for 30-45 minutes, control the temperature below 45°C, thin layer Chromatographic identification of inclusion endpoints.
[0026] Accordin...
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