Mannosan peptide and its prepn and use

A technology of mannan peptide and application, which is applied in the field of mannan peptide and its preparation, and can solve the problems of complex composition, large oral dose and the like

Inactive Publication Date: 2003-09-10
成都利尔药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 98121898 discloses "a kind of compound mannan peptide oral liquid", which contains multiple components, and its mannan peptides are from basidiomycete fungi, Septobasidiomycetes fungi, Polyporacea fungi, and Umbelliferae fungi. complex, large oral dose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0044] The ethanol concentration in the extraction process of step ii is 60-99.9%. Example two, mannan peptide identification

[0045] 1. Identification of strains: see the identification records of strains.

[0046] 2. Identification of semi-finished products:

[0047]i. Determination of absorbance: take an appropriate amount of semi-finished product sample, add water to make a solution containing 0.4mg in every 1ml, according to spectrophotometry (Chinese Pharmacopoeia 2000 edition two appendix VI A), at the wavelength of 260nm, its absorbance must not be greater than 0.25, at the wavelength of 280nm, its absorbance shall not be greater than 0.20.

[0048] ii. Content determination:

[0049] a. Preparation of reference substance solution Accurately weigh 0.1g of D-mannose reference substance dried at 105°C to constant weight, put it in a 100ml measuring bottle, add water to dissolve and dilute to the mark, shake well; precisely measure 5ml, put it in a 100ml In a measuri...

experiment example 2

[0201] The above experimental results show that the mannan peptide (weight average molecular weight 1-200,000) has a faster onset of action than the original large weight average molecular weight mannan peptide, and the curative effect is good, which may be the same as the purity of the mannan peptide (weight average molecular weight 1-200,000). Higher and easier to be absorbed by the body, clinical use of mannan peptides (weight average molecular weight 1-200,000) will achieve better curative effect. The above experimental results improve the quality standard of mannan peptides. The weight average molecular weight used is 10,000 to 200,000 mannan peptides provide a good basis for pharmacodynamic experiments. Experimental Example 2 Clinical Trial

[0202] Through the clinical treatment control observation of 871 patients with leukopenia and low immune function (including 300 patients with repeated upper infection), the results show that: 1. Mannan peptide has a good curative e...

Embodiment 1

[0206] Mannan Peptide 60g Starch 720g

[0207] Appropriate amount of distilled water Magnesium stearate 20g

[0208] Take 60g of mannan peptide, dissolve it with distilled water at 50-60°C, add starch to make soft material, granulate with 14-mesh nylon sieve, dry at 50°C, granulate with 12-mesh sieve, add lubricant stearic acid The magnesium is evenly mixed, filled into capsules, and subpackaged to make 1000 capsules.

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Abstract

The mannosan peptide is a kind of fermentation product from Streptococcus hemolyticus-alpha. The mannosan peptide has weight average molecular weight of 10-200 KD and molecular weight distributing coefficient below 4.0. The present invention also provides the preparation process and use of the mannosan peptide.

Description

technical field [0001] The present invention provides a mannan peptide and its preparation process and application, specifically, mannan from a fermentation product of α-hemolyticus-α-Hemolysis with a certain weight-average molecular weight range Peptide and its preparation process and use. Background technique [0002] As the environment changes, the incidence of human tumors continues to increase, and the age of onset is also lower than in the past. Finding safe and effective anti-tumor drugs is the goal that human beings have been working hard for. [0003] Tumor treatment through the body's defense mechanism was advocated by the National Cancer Institute of the United States in the late 1970s, and gradually developed worldwide in the 1980s. Japan is at the forefront in the research and development of immune activators against tumors, and has been approved for production and marketing. Streptococcus preparations of hemolytic streptococci (OK-43...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61P7/00A61P11/00A61P35/00A61P37/04C07K14/315C12P21/00
Inventor 陈云华余清和李军李丽刘艳
Owner 成都利尔药业有限公司
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