DNA vaccine pVPH for SARS virus

A technology of SARS virus and DNA vaccine, which is applied in the field of medical bioengineering, to achieve the effect of simple preparation process, strong effect and strong prevention of virus infection
CN1449827AInactive Publication Date: 2003-10-22SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2003-10-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the field of medicinal biological engineering technology, and is a DNA vaccine pVPH for preventing SARS virus. It is composed of human coronavirus HE protein antigenic determinant code sequence and signal peptide code sequence of plasminogen activator TPA to form secreted HE protein antigenic determinant code sequence HE-P, then inserting it into the eukaryotic expression vector. Said recombinant plasmid transformed competence colibacillus DH5 alpha is the pVPH engineering bacterium which can be used for preparing vaccine pVPH. Because its expressed antigenic protein can be secreted to the exterior of cell, so that it raises the immunity of body fluid, and can have the better action for preventing infection of SARS virus.
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Description

Technical field:

[0001] The invention relates to the technical field of medical bioengineering, and relates to a DNA vaccine pVPH for preventing severe acute respiratory syndrome SARS virus. Background technique:

[0002] The World Health Organization referred to Severe Acute Respiratory Syndrome (SARS) as SARS, and confirmed that it is an infectious disease caused by the SARS virus (SARS coronavirus). At present, there is no specific drug for SARS virus, and it is imperative to develop an effective preventive vaccine. DNA vaccine is a new type of vaccine emerging in recent years, which has the advantages of long-lasting antibody titer and good cross-protection effect. In addition, the DNA vaccine also has the following outstanding advantages: (1) It can induce a full range of humoral and cellular immune responses and play a preventive role; (2) The immune protection time is long; (3) The production process is simple, the cost is low, the stability is good and the storage ...

Claims

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