Compound function supermicro magnetic carrier particle and its preparing method
A technology of composite function and carrier particles, which is applied in preparations for in vivo experiments, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of wide particle size distribution of magnetic particles, difficulty in having superparamagnetism, and outdated technology. and other problems, to achieve the effect of simple operation, wide versatility, and economical raw materials
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0047] In this example, the polymer carrier material is dextran (MW=40,000), and the biologically active functional preparation is epirubicin.
[0048] Preparation of X solution:
[0049] Dextran:FeCl 3 : Deionized water = 1: 1.5: 8 ratio preparation solution, and cooled to 0 ℃ in ice water bath, stand-by;
[0050] Preparation of Y solution:
[0051] with FeCl 2 : Deionized water=1:0.2 ratio preparation solution, cooled to 15 ℃ in ice bath, stand-by;
[0052] Put the X solution in a 4°C ice-water bath, add the Y solution and mix and stir. Heat the ice-water bath, control the temperature gradually to 50°C within 10 minutes, add 0.1 times the volume of 4 moles per milliliter of NaOH solution to the XY mixed solution at this temperature, and continue to stir the mixed solution for 30 minutes to obtain dark brown glucan Sugar superparamagnetic ultrafine particle colloidal solution; the obtained colloidal solution is fully dialyzed, and then subjected to magnetic separation, h...
Embodiment 2
[0060] In this example, the polymer carrier material is O-carboxymethyl chitosan (MW=100,000), and the bioactive functional preparation is doxorubicin hydrochloride.
[0061] Preparation of X solution:
[0062] O-carboxymethyl chitosan: Fe 2 (SO 4 ) 3 : Deionized water = 1: 2.3: 15 ratio to prepare the solution, and cooled to below room temperature in an ice-water bath, stand-by;
[0063] Preparation of Y solution:
[0064] FeSO 4 : Prepare the solution in the ratio of deionized water=1:4, cool to 4°C in an ice bath, and set aside;
[0065] Mix the X and Y solutions and place in an ice-water bath. Heat the ice-water bath so that the temperature gradually rises to 80°C in 30 minutes, keep the temperature, and add 0.5 times the volume of 1 mole per mL of NH 4 OH was added to the XY mixed solution, and the reaction was continued for 50 minutes to obtain a dark brown O-carboxymethyl chitosan superparamagnetic ultrafine particle colloidal solution; the colloidal solution was...
Embodiment 3
[0067] Same as the steps in Example 1, the difference is
[0068] In this example, the polymer carrier material is water-soluble oligomeric chitosan (MW=3,000), and the biologically active functional preparation is bleomycin.
[0069] Mix according to the ratio of formaldehyde oligo-chitosan superparamagnetic ultrafine particles: bleomycin: PBS buffer solution = 1: 0.4: 15, and react at room temperature for 24 hours in the dark. The reaction mixture is reduced by sodium borohydride, then purified and freeze-dried to obtain bleomycin-chitosan superparamagnetic ultrafine carrier particles with an average particle diameter of 70 nm.
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com