Compound function supermicro magnetic carrier particle and its preparing method

A technology of composite function and carrier particles, which is applied in preparations for in vivo experiments, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of wide particle size distribution of magnetic particles, difficulty in having superparamagnetism, and outdated technology. and other problems, to achieve the effect of simple operation, wide versatility, and economical raw materials

Inactive Publication Date: 2004-02-11
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing co-precipitation technology is outdated, the prepared magnetic particles have a wide particle size distribution, single function, it is difficult to have superparamagnetism, and the adaptability is narrow

Method used

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  • Compound function supermicro magnetic carrier particle and its preparing method
  • Compound function supermicro magnetic carrier particle and its preparing method
  • Compound function supermicro magnetic carrier particle and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] In this example, the polymer carrier material is dextran (MW=40,000), and the biologically active functional preparation is epirubicin.

[0048] Preparation of X solution:

[0049] Dextran:FeCl 3 : Deionized water = 1: 1.5: 8 ratio preparation solution, and cooled to 0 ℃ in ice water bath, stand-by;

[0050] Preparation of Y solution:

[0051] with FeCl 2 : Deionized water=1:0.2 ratio preparation solution, cooled to 15 ℃ in ice bath, stand-by;

[0052] Put the X solution in a 4°C ice-water bath, add the Y solution and mix and stir. Heat the ice-water bath, control the temperature gradually to 50°C within 10 minutes, add 0.1 times the volume of 4 moles per milliliter of NaOH solution to the XY mixed solution at this temperature, and continue to stir the mixed solution for 30 minutes to obtain dark brown glucan Sugar superparamagnetic ultrafine particle colloidal solution; the obtained colloidal solution is fully dialyzed, and then subjected to magnetic separation, h...

Embodiment 2

[0060] In this example, the polymer carrier material is O-carboxymethyl chitosan (MW=100,000), and the bioactive functional preparation is doxorubicin hydrochloride.

[0061] Preparation of X solution:

[0062] O-carboxymethyl chitosan: Fe 2 (SO 4 ) 3 : Deionized water = 1: 2.3: 15 ratio to prepare the solution, and cooled to below room temperature in an ice-water bath, stand-by;

[0063] Preparation of Y solution:

[0064] FeSO 4 : Prepare the solution in the ratio of deionized water=1:4, cool to 4°C in an ice bath, and set aside;

[0065] Mix the X and Y solutions and place in an ice-water bath. Heat the ice-water bath so that the temperature gradually rises to 80°C in 30 minutes, keep the temperature, and add 0.5 times the volume of 1 mole per mL of NH 4 OH was added to the XY mixed solution, and the reaction was continued for 50 minutes to obtain a dark brown O-carboxymethyl chitosan superparamagnetic ultrafine particle colloidal solution; the colloidal solution was...

Embodiment 3

[0067] Same as the steps in Example 1, the difference is

[0068] In this example, the polymer carrier material is water-soluble oligomeric chitosan (MW=3,000), and the biologically active functional preparation is bleomycin.

[0069] Mix according to the ratio of formaldehyde oligo-chitosan superparamagnetic ultrafine particles: bleomycin: PBS buffer solution = 1: 0.4: 15, and react at room temperature for 24 hours in the dark. The reaction mixture is reduced by sodium borohydride, then purified and freeze-dried to obtain bleomycin-chitosan superparamagnetic ultrafine carrier particles with an average particle diameter of 70 nm.

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Abstract

The present invention relates to superfine magnetic carrier particle with compound function and its preparation process. It is a kind of complex with three-layered core-shell structure including the first layer of ferric oxide, the second layer of polymer carrier material and the third layer of bioactive functional preparation. It has the compound functions of magnetic positioning, biological targeting positioning and controlled medicine release. The preparation process includes the following steps: preparing of super-paramagnetic superfine particle, covering the superfine carrier particle with bioactive functional preparation via physical coagulation and chemical linkage. The preparation process can prepare superfine magnetic carrier particle with compound function in 40-80 nm size and with narrow size distribution, good targeting property, controlled medicine release and thus important application foreground in local medicinal treatment and diagnosis carrier preparation.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to composite functional ultrafine magnetic carrier particles and a preparation method thereof. Background technique [0002] Magnetic material is a kind of functional material with excellent targeting and positioning characteristics, especially the magnetic properties of ultrafine particles are different from ordinary magnetic materials in terms of magnetic properties, thermal properties and chemical properties. Using these special properties, as early as in the world In the 1960s, some people began to study the preparation and application of ultra-fine magnetic particles, which are widely used in the field of biomedicine, such as carrier materials for local drug treatment or diagnosis, and carrying genes, polypeptide fragments or other biological materials. active agents, etc. With the development of nanoparticle research in re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/38A61K47/52A61K47/69A61K49/16
Inventor 常津原续波张晓金张爽男胡云霞朱斌李涛
Owner TIANJIN UNIV
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