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New medicinal use of liquorice polysaccharide and its medicinal preparation

A technology of licorice polysaccharides and pharmaceutical preparations, applied in the field of drugs for respiratory diseases, can solve the problems of licorice polysaccharides, etc., and achieve stable quality, no toxic and side effects, and significant curative effect

Active Publication Date: 2004-02-11
康奇(天津)生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no new medical application and pharmaceutical preparations of licorice polysaccharides for the treatment of chronic and recurrent respiratory tract infections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: Preparation of Glycyrrhizin Tablets

[0032] 1) Prescription: Licorice Polysaccharide 300g

[0033] Calcium hydrogen phosphate 285

[0034] Microcrystalline Cellulose 40g

[0035] Crospovidone 35g

[0036] Silica 35g

[0037] Magnesium Stearate 10g

[0038] 50% Alcohol 270ml

[0039] Makes 1000 pieces

[0040] 2) Preparation method: pass the raw materials through a 80-mesh sieve, and pass the auxiliary materials through a 100-mesh sieve for later use; first weigh the prescription amount of auxiliary materials (except 15g of crospovidone and an appropriate amount of magnesium stearate) and mix them evenly, and then mix them with licorice polysaccharide evenly, Granulate with 50% ethanol, sieve with 24 mesh to make soft material, dry at 55°C for 2 hours, sieve with 24 mesh for granulation, and set aside;

[0041] Add the above granules to the remaining crospovidone and magnesium stearate, and mix w...

Embodiment 2

[0042] Example 2: Preparation of licorice polysaccharide enteric-coated tablets

[0043] 1) Prescription:

[0044] 1. Isolation layer

[0045] Glycyrrhizin Tablets 680g

[0046] Hypromellose 3.6g

[0047] Titanium dioxide 7.2g

[0048] 70% ethanol 360ml

[0049] 2. Enteric coating layer

[0050] Acrylic resin L 100-55 43.5g

[0051] Triethyl citrate 4.4g

[0052] Talc powder 11g

[0053] Titanium dioxide 8.7g

[0054] Appropriate amount of color lake

[0055] 95% ethanol 790ml

[0056] Makes 1000 pieces

[0057] 2) Preparation method: First, prepare plain tablets according to the above-mentioned preparation method of glycyrrhizin tablets;

[0058] Disperse hypromellose and titanium dioxide in the prescribed amount in 70% ethanol, mix thoroughly and evenly, and obtain the film coating liquid of the isolation layer;

[0059] Put the plain tablet in the coating pot...

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PUM

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Abstract

The present invention relates to the application of licorice polysaccharide in preparing medicine for treating chronic recurrent respiratory tract infection. The medicine for treating chronic recurrent respiratory tract infection consists of licorice polysaccharide in 25-40 wt% and excipient or other medicine component in 60-75 wt%. The medicine may be prepared into tablet, capsule, granule, suspension, drip pill, oral liquid, aerosol or injection. The licorice polysaccharide preparation has the functions of benefiting vital energy, strengthening spleen and strengthening immunity, and has obvious curative effect of treating chronic recurrent respiratory tract infection and less toxic side effect.

Description

technical field [0001] The new medical application of licorice polysaccharide and its pharmaceutical preparation relate to the technical field of pharmaceuticals for respiratory diseases. technical background [0002] Licorice has been used in my country for thousands of years. The content of polysaccharides in licorice is relatively high, and the average content of licorice is reported to be 2% to 3%. CN 1343729A has published a patent application 0124539.2 "Glycyrrhiza polysaccharide". The raw materials used in this patent The roots and stems of licorice are boiled, the clear liquid is extracted, decolorized, concentrated, alcohol precipitated, centrifuged, dried, ground, sieved, and crude polysaccharides are obtained; crude polysaccharides are added with water at 4°C Filter and swell under lower pressure; take supernatant after centrifugation again; add deproteinization reagent (Sevage) to remove protein, dialyze with deionized water; DEAE-Cellulose (DE-32) column chromatog...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/715A61P11/00
Inventor 宋飞
Owner 康奇(天津)生物技术股份有限公司
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