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Compound preparation for treating and preventing thrombosis and apoplexia as well as its preparing method

A compound preparation and thrombus technology, which is applied in the field of compound preparations and their preparation, can solve the problems of large investment and large stimulation effect on the digestive tract, and achieve the effects of reducing production cost and reducing the fluctuation of drug action.

Inactive Publication Date: 2004-03-10
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Abroad has developed a kind of capsule preparation that adopts dipyridamole and aspirin to be made, and its technology needs to adopt the capsule machine of secondary filling, and this equipment investment is big, is not suitable for China's national conditions; Chinese patent CN 1227100A discloses such a kind of The preparation is a slow-release tablet of dipyridamole and aspirin. The applicant for the patent believes that aspirin has a strong irritating effect on the digestive tract, and the slow-release method must be adopted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Mix 200g of dipyridamole, 35g of hypromellose, 75g of lactose, and 25g of dextrin, add an appropriate amount of 20% ethanol as a binder, mix and make granules, dry at 60°C, and add 12g of talcum powder for lubrication agent, and then compressed into tablet cores;

[0026] The tablet core is coated according to the sugar coating operation method, and the coating steps are:

[0027] 1. Pack isolation gown

[0028] Dissolve and filter 2g of gelatin, mix it with 50ml of simple syrup, and then coat it. Add about 10ml of gum syrup, let it dry slightly, sprinkle an appropriate amount of talcum powder, and let it dry for about 10 minutes, then apply the second, third... coats in the same way until the calculated amount of gum syrup is applied. Then to be coated with aspirin sugar;

[0029] 2. Sugar-coated aspirin

[0030] Mix 25g of aspirin and 0.25g of citric acid into 100g of simple syrup, mix well to make an aspirin emulsion, and then coat it. The temperature of the coat...

Embodiment 2

[0037] Mix 200g of dipyridamole, 55g of hypromellose, 50g of lactose, and 20g of dextrin, add an appropriate amount of 20% ethanol as a binder, mix and make granules, dry at 65°C, and add 10g of talcum powder for lubrication agent, and then compressed into tablet cores;

[0038] The tablet core is coated according to the film coating operation method, and the coating steps are:

[0039] 1. Pack isolation gown

[0040] Add 10g of film coating premix into 150ml of 85% ethanol, milk evenly, and then coat. At ~45°C, continuously spray the isolation coating layer coating solution for coating operation, and then wait for the aspirin sugar coating;

[0041] 2. Pack aspirin layer coat

[0042] 25g of aspirin, 0.25g of citric acid, and 10g of film coating premix are added into an ethanol solution of 85% and 150ml in ethanol solution, and the aspirin coating solution is prepared, and then coated. 50°C, the rotating speed of the coating pan is 20-30 rpm, the temperature of the tablet...

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PUM

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Abstract

A slowly-releasing compound medicine in the form of tablet for treating and preventing thrombosis and apoplexy is prepared from aspirin, 2-(acetoxy) benzoic acid, slow-releasing dipyridamole, 2,2',2'',2''', [(4,8-dipiperidylpyrimido[5,4-d] pyrimidine-2,6-diyl) dihyponitido]-tetraethanol through granulating, tabletting and coating. Its advantages are high curative effect and equickly taking its effect.

Description

Technical field: [0001] The invention relates to a compound preparation for treating and preventing thrombosis and stroke and a preparation method thereof, in particular to a compound sustained-release tablet for treating and preventing thrombosis and stroke and a preparation method thereof. Background technique: [0002] 2,2', 2", 2'', [(4,8-dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl) dinitrilo]-tetraethanol (bipyrimidin Damo, synonym dipyridamole) is a widely used clinical anti-platelet aggregation drug, mainly used to prevent thrombosis, arteriosclerosis and myocardial infarction recurrence and other diseases. 2-(acetyloxy)benzoic acid (acetylsalicylic acid , synonymous aspirin) is a traditional antipyretic, anti-inflammatory, and analgesic drug. Both aspirin and dipyridamole are confirmed antiplatelet drugs. Stroke, arterial thrombosis, etc. At present, the use of antiplatelet drugs has become an effective treatment method in the prevention and treatment of heart a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/60A61P7/02A61P9/10
Inventor 倪友洪曹勇蒲春霞张玲
Owner CHENGDU LIST PHARMA
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