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Oral digestible film and its preparing process and use

A technology of digestible film and oral cavity, which is applied in the direction of digestive system, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of limited bactericidal ability and high production cost of essential oils, and achieve the effect of keeping fresh and convenient to use

Inactive Publication Date: 2004-07-14
SHANGHAI HI TECH UNITED BIO TECHCAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In PCT patent WO 00 / 18365, a fast-dissolving oral consumption film is disclosed, the main components are water-soluble polymers and an antibacterial effective amount of essential oils, the essential oils are thymol, methyl salicylate, eucalyptol and menthol Any kind of alcohol, but the production cost of essential oil is high, and the bactericidal ability is limited, so more economical and effective products are needed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of oral digestive film

[0037] The composition of the oral digestive film is as follows:

[0038] Modified starch 6%;

[0039] Lysostaphin 0.01%

[0040] Lysozyme 0.4%

[0041] Antimicrobial peptide 0.0001%

[0042] Locust bean gum 0.06%;

[0043] Carrageenan 0.3%;

[0044] Menthol 0.7%.

[0045] Water balance

[0046] For the preparation method of antimicrobial peptides, please refer to the patent application document titled "a group of synthetic antimicrobial peptides" and the application number is 02136766.3.

[0047] The above-mentioned substances were prepared according to the following method: locust bean gum and carrageenan were dissolved in water and soaked for 24 hours to form preparation A; the modified starch was dissolved in water, added to liquid A, stirred evenly, placed, and hydrated for 24 hours to form preparation B; Add menthol to polyethylene glycol 400, mix thoroughly to form preparation C; add preparation C to preparation B, mix t...

Embodiment 2

[0049] Example 2 Testing the antibacterial efficacy of oral digestive film

[0050] 1. Preparation of test samples:

[0051] Except for the bactericidal ingredients, the other formulas are as follows:

[0052] Modified starch 6%;

[0053] Locust bean gum 0.06%;

[0054] Carrageenan 0.3%;

[0055] Menthol 0.7%.

[0056] Water balance

[0057] Sample 1: Lysostaphin 0.01%

[0058] Sample 2: Lysozyme 0.01% Lysozyme 0.4%

[0059] Sample 3: Antimicrobial peptide 0.0001%

[0060] Sample 4: Lysostaphin 0.01% Lysozyme 0.4% Antimicrobial peptide 0.0001%

[0061] The preparation method is as in Example 1.

[0062] 2. Test strains: Staphylococcus aureus CMCC26003, Escherichia coli ATCC8099, Candida albicans, Streptococcus hemolyticus, Klebsiella pneumoniae (the above strains were purchased from the China Institute for the Control of Biological Products). The concentration of the test bacterial suspension meets the test requirements 5×10 5 ~5×10 6 cfu / ml.

[0063] 3. Test method: According to t...

Embodiment 3

[0075] The irritation test of oral digestive film on vaginal mucosa of experimental animals

[0076] 1. Sample preparation: Refer to Example 1 for the preparation method of the oral digestive film, and the formula is as follows:

[0077] Modified starch 6%;

[0078] Lysostaphin 0.08%

[0079] Lysozyme 5%

[0080] Antibacterial peptide 0.001%

[0081] Locust bean gum 0.06%;

[0082] Carrageenan 0.3%;

[0083] Menthol 0.7%.

[0084] Water balance

[0085] 2. Experimental animals: SD rats, female, ordinary grade, 18, weighing 230g-250g, randomly divided into three groups, oral digestive film group and blank control group, each group has 6 animals, provided by the Experimental Animal Department of Fudan University .

[0086] 3. Test method: Refer to Article 3.8 in the Disinfection Technical Specification (Third Edition) 1999.11. Put the oral digestive membrane into the animal’s vagina and contact the vaginal mucosa. The blank control group did not do any treatment. The animals were sa...

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PUM

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Abstract

The oral digestible film includes water soluble polymer, enzyme and / or polypeptide in effective antibacterial amount. Test shows the oral digestible film can kill Staphylococcus aureus, colibacillus, Candida albicans, Streptococcus hemolyticus, Klebsiella pneumoniae and other disease-causing bacteria. The rat vagina mucous membrane stimulating reaction test shows the highest total integration value being zero, and the oral digestible film has no any stimulation to oral cavity mucous membrane. Halimeter test proves its oral cavity protecting effect in four hours and capacity of protecting fresh oral smell. The oral digestible film is used in killing harmful bacteria in oral cavity, keeping clean oral cavity and preventing and treating oral diseases.

Description

Technical field [0001] The invention relates to an absorbable biocompatible material, in particular to a digestible oral cavity film and its preparation method and application. Background technique [0002] Modern people pay great attention to oral hygiene. At present, most of the substances used for oral cleaning, disinfection and sterilization are chewing gum and other substances that need to be chewed. This not only distracts people and makes behavior unsightly, but also produces waste and affects The public health environment. The other type is oral sprays, which can provide rapid oral cleaning, disinfection and sterilization, but at the same time, due to the larger volume of the spray packaging, it is not dexterous to carry. Moreover, the scattered spray has poor purpose, and may cause irritation to other parts of the body due to improper use. [0003] The use of film-like substances for oral cleaning, disinfection and sterilization, is increasingly popular with consumers du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K38/43A61P1/02
Inventor 黄青山
Owner SHANGHAI HI TECH UNITED BIO TECHCAL RES
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