Novel 4-amino-5,6-substituted thiopheno 2,3-d]pyrimidines

A compound, alkyl technology, applied in the field of 4-amino-5, can solve problems such as cell death
CN1522258AInactive Publication Date: 2004-08-18BAYER CORP
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BAYER CORP
Publication Date
2004-08-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B(PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.
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Description

field of invention

[0001] The present invention relates to 4-amino-5,6-substituted thieno[2,3-d]pyrimidine compounds, pharmaceutical compositions containing said compounds, and said compounds in the treatment or prevention of phosphodiesterase 7 B (PDE7 B )-mediated diseases and conditions. by PDE7 B Mediated diseases and conditions include osteoporosis, osteopenia, and asthma. The present invention also relates to methods of preparing 4-amino-5,6-substituted thieno[2,3-d]pyrimidine compounds, and methods of preparing compositions containing said compounds. Background of the invention

[0002] Cyclic nucleotide phosphodiesterase (PDE) exhibits specificity for purine cyclic nucleotide substrates and catalyzes the hydrolysis of cyclic AMP (cAMP) and cyclic GMP (cGMP) (Thompson, W.J. (1991) Pharma.Ther.51 :13-33). Cyclic nucleotide phosphodiesterases regulate steady-state levels of cAMP and cGMP and regulate the magnitude and duration of cyclic nucleotide signaling. These...

Claims

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