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Method for preparing polyurethane medical anti-infectious interventional catheter

An interventional catheter and anti-infection technology, applied in catheters and other directions, can solve the problems of limited selection of antibacterial agents, catheter damage and deformation, and coating thickness restrictions, and achieve the effects of convenient operation, high loading capacity, and low cost

Inactive Publication Date: 2004-09-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first two methods often involve the use of polar solvents, which lead to catheter damage and deformation and printing ink detachment, and are also limited by the thickness of the coating; while the latter method requires special and expensive equipment, and also has great limitations on the selection of antimicrobial agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 500 grams of composite antibacterial agent (inorganic silver-carrying antibacterial agent and organic antibacterial agent triclosan are mixed in a mass ratio of 1:9) and 1500 grams of polyethylene-vinyl acetate (vinyl acetate content is 28%) into a vacuum oven Dry for 12 hours with an oven temperature of 60°C. Remove after cooling to room temperature. Mix the compound antibacterial agent and polyethylene-vinyl acetate evenly, add it into the feed hopper of the twin-screw machine, and extrude and granulate. The prepared master batch was put into a vacuum drying oven (temperature of 60° C.) for drying for 24 hours. Take 140 grams of antibacterial pellets, mix with 1860 grams of dried barium sulfate mixed polyurethane, add to the hopper of a single-screw extruder, and extrude to obtain a catheter with anti-infection function.

Embodiment 2

[0028] Put 400 grams of composite antibacterial agent (ciprofloxacin and rifampicin are mixed in a mass ratio of 1:2) and 1600 grams of barium sulfate-doped polyurethane into a vacuum oven for drying for 12 hours, and the oven temperature is 80°C. Remove after cooling to room temperature. Mix the composite antibacterial agent with barium sulfate-doped polyurethane, then add 4 grams of antioxidant 1010, 3.2 grams of UV stabilizer 770, 7 grams of zinc stearate and 7 grams of calcium stearate, and mix the raw materials evenly. , added to the feed hopper of the twin-screw machine, extruded and granulated. The prepared master batch was put into a vacuum drying oven (temperature of 80° C.) for drying for 24 hours. Take 40 grams of antibacterial masterbatch, mix it with 1960 grams of dried barium sulfate-doped polyurethane, add it to the hopper of a single-screw extruder, and extrude to obtain a catheter with anti-infection function.

Embodiment 3

[0030] Put 700 grams of composite antibacterial agent (inorganic silver-carrying antibacterial agent and minocycline are mixed in a mass ratio of 1:8) and 1300 grams of polyether polyurethane into a vacuum oven for drying for 12 hours, and the oven temperature is 70 ° C. Remove after cooling to room temperature. Then the composite antibacterial agent is mixed with polyether polyurethane, and then 4 grams of antioxidant 1010, 1.6 grams of UV stabilizer 770, 16 grams of zinc stearate and 16 grams of calcium stearate are added, and the raw materials are mixed evenly. , added to the feed hopper of the twin-screw machine, extruded and granulated. The prepared master batch was put into a vacuum drying oven (temperature of 80° C.) for drying for 24 hours. Take 100 grams of antibacterial masterbatch, mix it with 1900 grams of dried barium sulfate-doped polyurethane, add it to the hopper of a single-screw extruder, and extrude to obtain a catheter with anti-infection function.

[003...

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PUM

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Abstract

The invention relates to a polyurethane medical anti-infection insertion guide tube preparing method, preparing antimicrobial-containing antibacterial mother material to mix with the polyurethane raw material, and extruding to shape so as to obtain the guide tube, its antimicrobial loadage high and its antibacterial effect more permanent; its inner and outer walls has the same antibacterial effect; the technique is simple, the operation is convenient and the cost is low.

Description

technical field [0001] The invention relates to a method for preparing a medical anti-infection interventional catheter, in particular to a method for preparing a polyurethane medical anti-infective interventional catheter by using an antibacterial masterbatch. Background technique [0002] Medical interventional catheters have been widely used in clinical treatment. However, during the use of medical interventional catheters, bacteria are often adsorbed on the surface of the catheter to cause infection, which limits the use of the catheter. It is generally believed that infection begins at the opening of the epidermis. After bacteria undergo a dynamic reversible adsorption and irreversible adhesion process on the surface of the material, they attach and secrete to the surface of the material to form a biofilm, which can protect the bacteria in the film from the host. The immune mechanism and the influence of antibiotics can also promote the furthe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16
Inventor 姜宏伟卢珣黄洪伟崔跃飞
Owner SOUTH CHINA UNIV OF TECH
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