Medicinal preparation of general alkaloid of bocconia cordata and producing method

A technology to recover total alkaloids and total alkaloids, which can be used in pharmaceutical formulations, drug combinations, drug delivery, etc., and can solve the problems of fungal sensitivity, aerobic bacteria and fungi are ineffective, and not seen.

Inactive Publication Date: 2004-10-27
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 4 toxicity
[0013] Chinese patent CN1118253A is a patent of metronidazole effervescent tablet, which has obvious curative effect on trichomonas infection and anaerobic infection, but is ineffective against aerobic bacteria and fungi; Chinese patent CN1068208C is a patent on a gynecological special The patent of traditional Chinese medicine tablet and its production method, which is a compound preparation, is effective against Staphylococcus aureus, Klebsiella, and Staphylococcus albus, sensitive to fungi, and whether it is sensitive to Trichomonas has not been reported
There is no report of making Boluohui into effervescent tablets, effervescent capsules, or effervescent suppositories, nor is there any effervescent agent that uses Boluohui's total alkaloids as active ingredients in the treatment of clinical gynecological diseases report

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0034] Take citric acid and dry it at 100°C to make weathering; NaHCO 3 Dry at 50°C for later use. Take polyethylene glycol 6000 (to dry NaHCO 3 by weight) 1 part, melt, add 2 parts of NaHCO 3 Dry powder, fully mixed evenly, wrapped, cooled, crushed through 80-mesh sieve. Take Boluohui total alkaloids 350g, and the same amount of carboxymethyl starch, dry and pulverize through a 120-mesh sieve for later use. According to 1:2.3:10 take citric acid powder, NaHCO 3Wrapping powder and Boluohui total alkaloids are mixed with sodium carboxymethyl starch, and an appropriate amount of magnesium stearate is added, and each tablet is pressed into oval tablets of 1g to obtain 1000 effervescent tablets, which are packed in aluminum-plastic blisters, to obtain Bo Luohui total alkaloid effervescent tablet of the present invention.

Embodiment 2

[0036] Take citric acid and dry it at 100°C, weather it, crush it through 80 mesh, and set it aside. Take polyethylene glycol 6000 (to dry NaHCO 3 by weight) 0.5 part, melted, added 80 mesh NaHCO which was dried and pulverized at 50°C 3 1 part, mixed well, wrapped, cooled and crushed through 80-mesh sieve. Boluohui total alkaloids 150g, and the same amount of carboxymethyl starch sodium are dried and pulverized through a 120-mesh sieve for later use. According to 1:2.3:10 take citric acid powder, NaHCO 3 Wrapping powder and Boluohui total alkaloids are mixed with sodium carboxymethyl starch, sprayed with an appropriate amount of 95% ethanol solution, granulated through a 20-mesh sieve, dried at 50--70°C for 2 hours, and packed into No. 0 capsules, each capsule Amount of 0.4g, to get 1000 effervescent capsules, packed in aluminum-plastic blisters, to get Boluohui total alkaloid effervescent capsules of the present invention.

Embodiment 3

[0038] Take 78g of citric acid, dry it at 100°C, weather it, crush it through 80 mesh, and set it aside; take NaHCO 3 84g was dried at 50°C, crushed and passed through a 80-mesh sieve for later use. Take the total alkaloids of Boluo and grind them through a 120-mesh sieve for later use. Take Boluohui total alkaloids 150g, crush and pass through a 120 mesh sieve for later use. Take polyethylene glycol 400 400g and polyethylene glycol 6000 200g, after heating and melting in a water bath, add NaHCO under stirring 3 powder, fully mixed evenly; then add citric acid, total alkaloids of Boluohui, and appropriate amount of penetration enhancer, mix well, pour into a mold, cool, remove the film, and pack to obtain the total alkaloids of Boluohui of the present invention Effervescent suppositories. Each Boluohui total alkaloid effervescent suppository weighs 3g, and 300 effervescent suppositories are obtained. Each capsule contains 0.5g of total alkaloids of Boluohui.

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PUM

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Abstract

An externally-applied medicine in the form of effervescent tablet, capsule, or suppository for treating gynopathy is prepared from pink plumepoppy herb's alkaloid and medicinal auxiliary. Its advantage is high curative effect. Its preparing process is also disclosed.

Description

Technical field [0001] The present invention relates to a medicine for treating gynecological inflammation, more specifically relates to an externally used medicine for treating gynecological inflammation with the total alkaloids of Boluohui as an active ingredient, and relates to a preparation method of the medicine. Background technique [0002] Boluohui is a perennial plant of the poppy family Boluohui, which is widely distributed in my country. It is cold in nature, pungent, bitter, and astringent, and has the effects of killing insects, reducing swelling, and relieving pain. Using Boluohui to treat scabies, and furunculant to kill insects and maggots have a long history in my country. Modern medicinal chemistry studies have shown that Boluogui contains sanguinarine, chelerythrine, pro-opioid, Boluogui and other alkaloids. Pharmacological studies have shown that alkaloids in Boluohui have the following pharmacological effects: [0003] 1 antibacterial effect [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K9/20A61K9/46A61K9/48A61K31/4741A61P15/00
Inventor 张晴龙
Owner 张晴龙
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